This study, published in the journal Atherosclerosis, found that statin use is associated with a 52% increased prevalence and extent of coronary artery plaques possessing calcium. The study was preceded by an earlier study which found that coronary artery calcification ”was significantly higher in more frequent statin users than in less frequent users,” among patients with type 2 diabetes and advanced atherosclerosis.
Coronary artery disease is one of the primary risk factors for heart attack and cardiac mortality, and calcification marks the end-stage of atherosclerosis, the gradual plaque-driven narrowing of the arteries, as the lumen (opening of the artery) can no longer compensate for the obstructive build-up of plaque by expanding, once the calcification process has taken place. Statins are increasingly recognized to have profound cardiotoxic properties, despite their widespread use in the prevention and treatment of heart disease. Read more: