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Joseph Pickrell
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Based on the poster, this documentary on archaic admixture looks like it'll be better than the original papers.

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Nearly all of the RNA-DNA differences identified by Li et al. last year are technical artifacts.

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Wow. Is this for real?

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A few initial thoughts on 23andMe's new $999 exome product:

1. The company steers clear of the FDA's baleful gaze by (at least initially) offering raw data only with no analysis.

2. This is for hardcore beta testers only. A raw exome sequence with no interpretation requires some serious data-wrangling to extract useful data from. Even existing open-access interpretation tools like Promethease will provide fairly overwhelming data.

3. The offer is open only to existing customers. That has two benefits: the one they emphasise on their site is that it selects for people with at least some experience in looking at genetic data. A more important (but unstated) benefit is that the customers' chip data will provide a comparison data-set for exome quality control.

4. We shouldn't forget that Knome has been offering both genome and exome sequencing DTC (along with interpretation) for a long time. However, my sense is that they've attracted relatively few customers. I suspect 23andMe will be able to rope in a substantially larger customer base even at a comparable price point, leveraging their marketing and community-building strengths.

5. Still, no question that the number of people willing to fork out $999 for a non-clinical-grade exome is pretty small.

6. At Genomes Unzipped we'll be looking to get hold of at least one of these exomes, as well as providing some suggestions on ways in which the raw data can be used. Exciting times for those of us who've spent the last few years working with sequence data...

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+Henry Harpending writes that a paper by +Graham Coop and I "roars like a mouse". Ouch.

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"Who are the most ruthless capitalists in the Western world? Whose monopolistic practices makes WalMart look like a corner shop and Rupert Murdoch look like a socialist? You won’t guess the answer in a month of Sundays. While there are plenty of candidates, my vote goes not to the banks, the oil companies or the health insurers, but – wait for it – to academic publishers."

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"At low density, group members tend to walk side by side, forming a line perpendicular to the walking direction. As the density increases, however, the linear walking formation is bent forward, turning it into a V-like pattern. These spatial patterns can be well described by a model based on social communication between group members. We show that the V-like walking pattern facilitates social interactions within the group, but reduces the flow because of its “non-aerodynamic” shape."

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0010047

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"All the big tech companies have started amassing troves of software patents — not to build anything, but to defend themselves. If a company's patent horde is big enough, it can essentially say to the world, "If you try to sue me with your patents, I'll sue you with mine."

It's mutually assured destruction"
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