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Yale Psychiatry

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Howard Zonana, M.D., was honored at a reception at the American Medical Association's Interim Meeting in Washington, D.C. Zonana is retiring as medical director of the American Academy of Psychiatry and the Law (AAPL).
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A Yale neuroscientist and psychiatry professor has developed an enrichment program that could help children with attention-deficit/hyperactivity disorder stay on task and avoid getting distracted.
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Yale Psychiatry

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Dr. Philip Corlett, assistant professor of psychiatry at Yale, contributes a guest post to The Scicurious Brain blog: "Sleight of Hand, Sleight of Mind: Illusions, Delusions and the Immune System"
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Yale Psychiatry

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Major depression or chronic stress can cause the loss of brain volume, a condition that contributes to both emotional and cognitive impairment. Now a team of researchers led by Yale scientists has discovered one reason why this occurs — a single genetic switch that triggers loss of brain connections in humans and depression in animal models.
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Yale Psychiatry

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June's 'Medicine@Yale' features Marina Picciotto, PhD, Charles B. G. Murphy Professor of Psychiatry and the department's assistant chair for basic research. Dr. Picciotto’s research not only sheds light on nicotine’s effects on the brain, but also has implications for for other important health issues, such as controlling obesity and the development of effective pain medications that do not lead to drug dependence.
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Have them in circles
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Yale Psychiatry

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Low-income mothers who cannot afford diapers are also more likely to report symptoms of depression and anxiety. Read more: http://bit.ly/16tP2UJ
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Yale Psychiatry

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Samuel Wilkinson, one of our residents, has published a commentary regarding the link between cannabis use and the development of schizophrenia and related disorders. Read more: http://t.co/ROmVlpn5S8
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Yale Psychiatry

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The August 2012 Psychiatry@Yale e-newsletter is online! Read the department's latest research, faculty, and alumni news. To get future editions by email, sign up here: http://bit.ly/kGoSSK
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In 1977, Austrian pathologist Dr. Kurt Jellinger published not only some of the most important findings in human recipients of various antipsychotics [including Haldol] but also a key summary of findings from numerous non-human animal species. In all cases (rabbits, guinea pigs, monkeys) therapeutically relevant doses of antipsychotic drugs delivered over a period of 12 days to 12 months resulted in diffuse damage throughout the brain.

Most recently,researchers at the University of Pittsburgh investigated the effects of Zyprexa and Haldol in male macaques. Drug exposures lasted 18 to 24 months. Post-mortem examination of brain tissue revealed dramatic reductions in fresh brain weight (10%). Subsequent analyses of the parietal lobe tissue demonstrated an 8-10% reduction in total cell number; 6% reduction in neuronal number, 10-18% reduction in the number of astrocytes or oligodendrocytes.

Most importantly, brain scan studies in humans
have repeatedly demonstrated brain volume reductions
following exposures to old and new antipsychotic drugs.

Although the public is not hearing about them,
the mechanisms of these effect are increasingly well studied and include:

mitochondrial toxicity [induction of apoptosis)
membrane disruption [lysosomic trapping, autophagy]
oxidative stress
weakening of the blood-brain-barrier
nutrient depletion
endocrine disruption
insulin dysregulation
enhancement of Alzheimer's disease "markers" >>

increased tissue transglutaminase increased levels of apoD increased levels of tau protein

Sadly, governmental regulators, medical schools, and health care systems do not yet seem interested in responding to this 60-year public health crisis.

Concerned readers of this posting may be interested in my book, Drug Induced Dementia – a perfect crime.

Grace E. Jackson MD
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Yale's Department of Psychiatry launches a wellness initiative for its faculty, residents, and staff. Read about the program and much more in July's "Psychiatry@Yale"
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The Yale Stress Center and the Department's commencement awards lead the June edition of Psychiatry@Yale.
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Yale Psychiatry is a world leader in patient care, research, and education.
Introduction
The Yale Department of Psychiatry is a world leader in patient care, research, and education. Our Department prides itself on its diverse and talented faculty, including a cadre of compassionate clinicians, inter-disciplinary teams of talented investigators, and numerous committed and dedicated teachers, as well as a network of able alumni that remain vital to our missions. As a Department, we not only provide the highest quality of patient care, but also lead the nation in discoveries that are transforming our understanding and treatment of mental illness.