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Ivan Mashchenko
Attends School of Hard Knocks
Lives in Prague, Czech Republic
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STSS (Simple Time Series Statistics) update is released featuring numerous important bug fixes and new features. Get it at
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Ivan Mashchenko

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Best Friends.....
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Math concepts which are easy to explain visually:

- why circles and right-angle triangles and angles are all related
- why sine is opposite over hypotenuse and so on
- why cosine is simply sine but offset by pi/2 radians .
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"Neanderthals, once one of our closet living relatives, split off on the family tree approximately 550,000 to 765,000 years ago, though recent evidence suggests there was intermingling before Neanderthals, for whatever reason, disappeared. They are considered to be an extinct species of human beings, of the genus Homo. They lived throughout Eurasia, from Western Europe to Central and Northern Asia, and may have died out as recently as 45,000 years ago (the date is still in dispute.) They have been in the news of late as scientists have discovered that Neanderthals and modern humans interbred— approximately 1.5 to 2.1 percent of the genomes of modern non-African people today is Neanderthal. In this new effort the research team sought to learn more about the Neanderthal people by examining their DNA and comparing it with groups living in different regions and with modern humans.
The team collected Neanderthal genome samples from specimens discovered in Spain, Croatia and southern Siberia focusing on 17,367 specific genes that are responsible for generating proteins, and in particular, mutations in those genes that create changes in amino acids.
Under analysis, the DNA revealed a less diverse gene pool suggesting that Neanderthals lived in small groups and didn't tend to interact with other groups. It also showed that Neanderthals underwent more skeletal changes than modern humans, though modern humans underwent more pigmentation and apparent behavioral changes than did Neanderthals. The team also identified amino acid substitutions in Neanderthals and modern humans that may underlie phenotypic (composites of an organism's physical traits and behaviors) differences between the two groups".
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Ivan Mashchenko

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FlowGraph is released! Some minor bugs are fixed, NodeMoved event is added. Get it at
I have just released #FlowGraph my flow #charts ( #graphs ) visualization and editing library (a #WinForms .Net control) (that I have decided to develop after finding almost no reasonable alternatives) to public. It is based on Thomas Iche's #NodeGraph but is heavily refactored, cleaned up and enhanced to fit my (and yours, I hope) needs. See more information and download the library and its C# source code at
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Ivan Mashchenko

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Artwork by Pino Daeni
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Ivan Mashchenko

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Epigenetics 101.

#Epigenetics refers to modifications to the DNA or the proteins associated with DNA, such as histones, which in turn determine whether a gene is on or off or whether its activity is high or low.

Examples of these modifications include acetylation, methylation and phosphorylation. These modifications are added to histones by enzymes called writers and removed by enzymes called erasers. Other proteins, called readers, recognize a specific pattern of modifications by binding to them and recruiting additional proteins to regulate gene activity. Differences in the pattern of modifications occur between different cells and organs of the body or in response to different physiological stimuli.

There is now substantial evidence that alterations in these patterns underlie multiple diseases. For these reasons, epigenetics has become an exciting forefront for the discovery of new medicines.

Useful resources

- Wikipedia: In biology, and specifically genetics, epigenetics is the study of heritable changes in gene activity that are not caused by changes in the DNA sequence; it also can be used to describe the study of stable, long-term alterations in the transcriptional potential of a cell that are not necessarily heritable. Unlike simple genetics based on changes to the DNA sequence (the genotype), the changes in gene expression or cellular phenotype of epigenetics have other causes, thus use of the term epi- (Greek: επί- over, outside of, around) genetics.  (

- University of Utah Genetic Science Learning Center: As an organism grows and develops, carefully orchestrated chemical reactions activate and deactivate parts of the genome at strategic times and in specific locations. Epigenetics is the study of these chemical reactions and the factors that influence them. (

- Nature Education: Epigenetic Influences and Disease. The behavior of a person's genes doesn't just depend on the genes' DNA sequence - it's also affected by so-called epigenetic factors. Changes in these factors can play a critical role in disease. (

Larger view:
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Unlocking secrets of new solar material

A new solar material that has the same crystal structure as a mineral first found in the Ural Mountains in 1839 is shooting up the efficiency charts faster than almost anything researchers have seen before -- and it is generating optimism that a less expensive way of using sunlight to generate electricity may be in our planet's future.

A new solar material that has the same crystal structure as a mineral first found in the Ural Mountains in 1839 is shooting up the efficiency charts faster than almost anything researchers have seen before -- and it is generating optimism that a less expensive way of using sunlight to generate electricity may be in our planet's future.
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Ivan Mashchenko

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Have him in circles
14,080 people
Leonel Erlichman's profile photo
A twisted mentat
IT consultant and project manager, Scala & C# & T-SQL developer, SMB IT system engineer, hotel and travel agency manager, business negotiatior, UX and business process critic, QA enthusiast, certified Rockwell Arena simulation modelling speciallist and trainer, fluent English, Russian and Czech speaker
  • IT consultant and project manager, present
Map of the places this user has livedMap of the places this user has livedMap of the places this user has lived
Prague, Czech Republic
Saint-Petersburg, Russian Federation - Yekaterinburg, Russian Federation - Vyborg, Russian Federation - Říčany, Czech Republic - Siegen, Germany
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Jedem das seine
In general

I am a person of very wide tastes and interests. I enjoy everything that «has a heart» (© C. Castañeda). I enjoy to meet and try to understand different people, to study and master different new things, to explore, to feel, to taste, to understand.

I consider myself a generalist rather than a specialist. The ultimate goal of a generalist is being a polymath and reconstructing the whole puzzle, the ultimate goal for a specialist as he specializes is, saying roughly, knowing everything about nothing. «... specialization is for insects.» " (© Lazarus Long (R. A. Heinlein)) :-)

In practice

I mostly earn my bread from working in IT, media and travel industries and their crossings, as well as participating as a manager in some venture projects of different areas (may you be looking for investments or to invest - I'd be glad if you could contact me) but I am always glad to switch to something new and extend my area of expertise.

My favourite programming language is Scala (the second favourite of mine is C#) but I can use many other languages if they fit better (for a particular task). I use Linux (XUbuntu) as my primary OS (I also like Windows XP, FreeBSD, QNX and DOS). I am a certified Rockwell Arena simulation engineer and trainer.

Location and communication

I live in Prague, Czech Republic (and feel it being the best place in the world I have been to, according to my taste).

I can speak English, Russian and Czech languages fluently. I can understand Slovak, Ukrainian and Belorussian with almost the same ease. I've also got some basic skills in French (used to speak near fluently but have forgotten because of lack of practice), German (studying right now), Polish and Hungarian. Needless to say I am fond of languages.

I prefer e-mail as the main communication channel, Skype when an audial conversation feels more convenient and Google+ as a social network. I am glad to meet exciting people from all over the world.

Social networking policy

All my posts are either public (the majority) or personal. I make no limited or circle-specific and almost no community posts.

I can hardly be insulted religiously (though I am not a pure atheist and don't advocate abuse) or any way alike. I never report posts other than those I can qualify as SPAM. At the same time I can myself post or reshare something of questionable appropriateness on occasion - if you are going to dislike that and don't want to see anything like that in your stream (or, for example, if your underage children can access your Googe+ on occasion) I strongly encourage you to unfollow and, if necessary, block me rather than to report.

I rarely post any original content. I mostly reshare whatever catches my eye. But I am not a bot and am prone to very active discussion participation in comments.

I use to review people who starts following me (as far as Google+ notifies me about it) and follow back if the profile seems an alive, interesting personality (I also don't mind explicit content or content of questionable appropriateness). But don't bother following me if you're a bot or a network marketer doing it just to get me follow back. If you think I might like following you but believe I have missed your emergence - please don't hesitate to leave a comment at a post of mine or contact me personally.

If you can't see any activity from my side for a relatively long period of time - that most probably neither means I'm dead nor I have given up using Google+. Some times I just need some solitude.

Religious views

What I usually testify to be my "religion" is agnosticism, a mild meritocratic, somewhat stoic sort. I personally believe that the G-d (whatever meaning we consider) speaks to one through his own reason and conscience and rarely through the mouths of clerics. I generally dislike fanaticism, excessive ritualism, dogmatism and clericalism, and condemn anti-secular, anti-education, anti-ecumenism, anti-sexuality and anti-equality parts. At the same time I think that almost all the religious, esoteric and philosophical teachings, as well as cultures and sciences harbour a piece of divine wisdom so I respect their followers as far as they act peacefully and with respect to others. Among the deadliest sins I condemn are hypocrisy, ignorance and their promotion. Among the key merits I value are intelligence, knowledge and honesty of a person to oneself (and to others of course but being honest to oneself is essential).

Political views

A state policy of my dream is liberal social technocracy. Liberal because people are to be free (while, not to forget, security (including social) is a precondition to freedom), social because taking care of the basic social as well as physical security is the ultimate function of a state and almost the only obvious reason for a state to exist (without it anarchy seems no worse), technocracy because serious things are to be engineered and driven a mindful way, by accordingly qualified professionals.
  • School of Hard Knocks
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Friends, Dating, A relationship, Networking
Other names
Иван Мащенко, Maščenko, Mascenko, Maschenko, Machtchenko