I'm running one WorkStation and one Server install, both upgraded without issues. ( fedup-cli --network 22 ; reboot )
yum has been deprecated, no big loss.
yum-cron can be replaced with dnf-automatic:
dnf install dnf-automatic
systemctl enable dnf-automatic.timer
change "apply_updates" from "no" to "yes" in /etc/dnf/automatic.conf
And all should be dandy.
Worst thing I've seen so far is that the wayland-enabled GDM login screen doesn't obey my rotation setting on the secondary screen anymore.