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Maximus Peto
Works at SENS Foundation
Attended University of Toledo
Lives in Keene, New Hampshire
306 followers|10,312 views
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Maximus Peto

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Exercising doesn't contribute much (if any) to development of arthritis, at least in mice. 

http://www.ncbi.nlm.nih.gov/pubmed/21405978
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Maximus Peto

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We stand on the verge of a revolution in medicine: understanding, treating, and ultimately preventing the causes of degenerative aging. But medical revolutions only happen if we all stand up in suppor...
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Rebecca Gorman shared this with me last night on Facebook. Looking into it now (wow)...Also wondering whether it is a hoax (i.e. too good to be true).
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To be honest, I'm not finished scrutinizing it yet. Doing so will take a while - lots of references to check, papers to read, etc. But yes, at first glance, it looks very promising to me too. However, there is plenty of fraud in the scientific publication industry, so one needs to do due diligence (as with everything) ;)
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Maximus Peto

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For those who saw my talk about insulin sensitivity at the Personalized Life Extension Conference in South San Francisco this past weekend: here are a few pics of my home-made treadmill desk (<$200 for all desk-related items, including the treadmill, which was $130, used from a craigslist.org sale).
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A Jolly
 
More info - but this time on metformin http://www.medpagetoday.com/Endocrinology/Diabetes/32146
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Very interesting and useful (and publicly available) paper on mercury and omega-3 content of canned tuna, mackerel, and salmon.
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Kitty, I was surprised to read in the article I linked that tuna was low in mercury. That is, I hadn't seen very much data on tuna, and I was pleased to find that tuna is low in mercury (although it's also low in omega-3). Given that mackerel is not much higher in price than tuna, it seems clearly better than tuna because of the omega-3 profile.
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Maximus Peto

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I am familiar with the micro tears and muscle building repair, but I was not cognizant of blood leakage and hemolysis of red blood cells in that same process.

I agree with you that I need to expand my general understanding of all the parts of the human body. My knowledge is mostly concentrated in energy metabolism, a result of my focus years ago on understanding insulin metabolism in an effort to simultaneously lose a lot of body fat and improve my insulin sensitivity (both of which, of course, are good). I have accumulated understanding of a few other narrow areas (such as some metals, such as iron, how they accumulate, how they facilitate the causing of molecular "damage", and how to get rid of them), and I've studied maybe a few dozen supplements.

Ah, one area I'm relatively well-informed about is exercise physiology, i.e. how to optimize strength gain and muscle mass accumulation from exercise (which is of limited use to me now that I'm "strong enough" IMO), as well as some knowledge of kinesthesiology (I'm using this word here as: http://en.wiktionary.org/wiki/kinesthesiology)

My point in saying all this is that I agree that it would be highly beneficial in my efforts to prolong my healthy life, as well as to develop additional methods that accomplish the same, if I greatly improve my understanding of all the parts and systems in the body and how they interact, and I agree that your learning recommendations above are good ones for me.
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I've been saying this for 5 years.....It's good that now there's a little more data on it.
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Ahh, interesting idea, Scott.
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Maximus Peto

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The role models we end up with (or choose?) can influence in ways you may not have considered:

http://www.sciencedaily.com/releases/2012/05/120507131948.htm
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Interesting: I first saw this about a month ago, but it appears there is more evidence for it than I thought: that leucine intake (as mTOR agonist) mediates much of the leptin secretion after a meal. This is news for you low-carbers who want to reduce body fat on low-carb diets, and are having a difficult time doing so. But be careful, since mTOR is also shown to be related some cancers.

http://ajpendo.physiology.org/content/291/3/E621.short

http://ajpendo.physiology.org/content/284/2/E322.short

http://ajpendo.physiology.org/content/289/1/E166.short
Abstract In vitro, leptin secretion is regulated at the level of mRNA translation by the rapamycin-sensitive mammalian target of rapamycin (mTOR) and its agonist leucine (Leu). Studies were conducted ...
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It's really the excessive stimulation of mTOR that leads to some cancers, which is a known outcome of consuming a high-protein low-fat medium-or-low carb diet.  Getting most of your calories from fat and using protein in a more moderate manner probably eliminates or greatly reduces those risks.
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Maximus Peto

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Illustrative (and informative) infographic on sitting for long periods of time being quite bad for one's health.

Interesting that the infographic was created by "medicalbillingandcoding.org". I wonder why these people made it? To inform people the harm of sitting too much, thereby encourage a decrease in health problems (which they'd have to "bill and code")? Or perhaps that some medical billers and coders are required to sit all day as part of their jobs, and they're making an argument that they don't want to do that anymore?

Note, I didn't review the references, so be sure to check them yourself (as I need to) to confirm the assertions stated in the infographic.

Thanks to +Paul Wakfer and +Kitty Antonik Wakfer for encouraging me to consider standing more. Kitty: I've been trying to stand nearly whenever possible, and I'm noticing an improvement in energy and focus, as well as in a small problem with my left knee (popping when bent) since standing. I'm now considering constructing/buying a treadmill desk, as I think it'll improve foot, leg, and lower back tiredness and circulation in the lower legs. I notice it's much more comfortable to slowly pace around the back yard while reading on my laptop, rather than stand still.

http://mashable.com/2011/05/09/sitting-down-infographic/
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Wow! I tracked down a paper related to this: http://www.metabolismjournal.com/article/S0026-0495(10)00315-X/abstract

One day of sitting reduced glucose uptake by 39% when eating more than ones calorie intake worth of food, and still by 18% even if one reduces food intake to reflect lower energy expenditure from the lowered activity (by sitting)!

Hooray for standing (and my treadmill desk)!

Although, I'm curious about what they did in the "active, no sitting condition" - was this standing? Or walking on a treadmill? Or running consecutive marathons all day? I'd bet the full-text would elaborate.
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Maximus Peto

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Re-post/share test from +Kitty Antonik Wakfer's Google+ page. I'm quoting her, below:

"Don't be part of the ruler/gov system! And dissuade others from taking or staying in such positions.
Even if not an enforcer - those willing to threaten and actually initiate physical force - such jobs enable enforcers to be oh so much more efficient....
Do something really value producing with technical skills & interest; something that enhances/promotes/enables voluntary mutually beneficial interactions. Making government more efficient at anything is NOT doing that!"
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I agree about figuring it out - it's not making perfect sense to me yet either.
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People
Have him in circles
306 people
Prasad Welikumbura (Sonna)'s profile photo
Maria Konovalenko's profile photo
Sean Ironstag's profile photo
Bhikkhu Samahita's profile photo
Janine Costanzo's profile photo
Robert Berger's profile photo
Franco Cortese's profile photo
Naomi Most's profile photo
Tracey Cen's profile photo
Work
Occupation
Currently: scientist and entrepreneur
Employment
  • SENS Foundation
    Scientist; LysoSENS, OncoSENS, 2010 - present
  • Davis College
    Master Instructor, 2008 - 2009
  • University of Toledo
    Adjunct Business Instructor, 2008 - 2008
  • Stautzenberger College
    Adjunct Bus. & Accounting Lecturer, 2007 - 2008
  • Enterprise Rent-a-car
    Regional Financial Accountant, 2007 - 2007
  • Techneglas, Inc.
    Cost Accountant, Payroll Accountant, Payables, 2006 - 2006
Places
Map of the places this user has livedMap of the places this user has livedMap of the places this user has lived
Currently
Keene, New Hampshire
Previously
Toledo, Ohio - Sunnyvale, California - Lambertville, Michigan - Columbus, Ohio - Toledo, Ohio
Story
Tagline
Striver: longevity scientist, economist, philosopher, independent thinker, rationalist, atheist...
Introduction
Maximus Peto studies biochemistry, longevity, politics, economics, efficiency, creativity, rationality and heterologous protein expression. He is currently (2012) working as a science literature analyst for SENS Foundation, after previously spending 2 years as a biochemical researcher at the SENS Foundation's Research Center in Silicon Valley on LysoSENS and OncoSENS. Generally, Max focuses much of his effort on extending the maximum, healthy human lifespan. He was previously an accountant and college accounting instructor, and holds a BBA in Finance, an MBA in Management, and a BA in Biochemistry (less 3 Spanish courses). 
Bragging rights
Lost 60 lbs by reading sci papers on weight loss and working really hard (diet, exercise). Diversity of experiences (~20 different jobs), undergrad work in computer sci., undergraduate degree in Finance, accountant and college accounting prof., research scientist, published scientific literature review (http://www.ncbi.nlm.nih.gov/pubmed/21142669), serial entrepreneur, writer, personal trainer, etc., etc.
Education
  • University of Toledo
    Biochemistry, 2009 - 2010
  • DeVry Institute of Technology
    Computer Science, 2001 - 2002
  • Monroe County Community College
    Computer Science, 1999 - 2001
  • California State University, Dominguez Hills
    MBA, 2005 - 2006
  • University of Toledo
    BBA Finance, 2002 - 2004
Basic Information
Gender
Male
Relationship
Single
Other names
Previous name: Steve Floyd Jr
Maximus Peto's +1's are the things they like, agree with, or want to recommend.
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