Allergic to her husband
BBC News reports on the case of Johanna Watkins who has a rare disorder (Mast Cell Activation Syndrome) that has caused her to become allergic to a whole bunch of stuff, including the scent of her husband. The allergy only developed after they got married.
At this point, they live in the same house but can no longer get close to each other. Instead they communicate via phone. Their "date night" involves watching a show together: "he will be three floors below me in a room on his laptop and I will be on mine and we'll watch the show at the same time and then text about it as we're watching it."