When people take the psychedelic drug LSD, they sometimes feel as though the boundary that separates them from the rest of the world has dissolved. Now, the first functional magnetic resonance images (fMRI) of people's brains while on LSD help to explain this phenomenon known as "ego dissolution."
As researchers report in the Cell Press journal Current Biology on April 13, these images suggest that ego dissolution occurs as regions of the brain involved in higher cognition become heavily over-connected. The findings suggest that studies of LSD and other psychedelic drugs can produce important insights into the brain. They can also provide intriguing biological insight into philosophical questions about the very nature of reality, the researchers say.
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