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gwern branwen
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Epidemiological surveillance year ended in July 2016 with 12 cases reported for the disease in CECAP/Eldorado, compared to 133 in the year that preceded it
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"Preventing future offending of delinquents and offenders: what have we learned from experiments and meta-analyses?", Mackenzie & Farrington 2015:

"*Objectives*: The main aim of this article is to review knowledge about what works in preventing future offending by delinquents and offenders. We examine what has been learned from randomized controlled trials (RCTs), systematic reviews, and meta-analyses in the past 10 years about the effectiveness of correctional interventions.
Methods: We focus on important recent RCTs, systematic reviews, and meta-analyses from 2005 onwards. Where reported in the meta-analyses, we examine the number of RCTs included in the analyses and whether results from experiments differ from those contained in non-experimental designs.
Results: Interventions based on surveillance, control, deterrence, or discipline are ineffective. Interventions based on restorative methods and skills training are effective. The effectiveness of interventions providing services and opportunities is unclear.
Conclusions: More randomized trials are needed to evaluate the effectiveness of programs. Only evidence-based programs should be implemented.
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gwern branwen

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In the extremity of the urban environment, natural selection is transforming species in unexpected ways.
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More than half the world’s population has no access to paved roads, so engineers are using an old technology to bring trucking to the sky.
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Last season was a strange one in my garden, notable not only for the unseasonably cool and wet weather—the talk of gardeners all over New England—but also for its climate of paranoia. One flower was the cause: a tall, breathtaking poppy, with silky scarlet petals and a black heart, the growing of which, I discoveredMore »
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a classic
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gwern branwen

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“This guy comes up — and I didn’t even recognize him at the time — and says, You tried to destroy my dissertation and I’m going to get you.”
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To reasonable people, this seems like an easy problem to solve:

"We represent an esteemed science publication. If you wish us to publish a paper, we will also publish all of the data which led to your findings via easily accessible download. If that is a problem for you, perhaps you want to consider a job in a less demanding field than the sciences. Perhaps politics."

And then carry through.

The essential grounding of scientific thought and philosophy is that experiments must be replicable. If an experiment cannot be replicated in physical nature, the data which led to those findings must be able to be analyzed by someone else to arrive at the same conclusions. If you, as a scientist, are unwilling or unable to provide that data to someone else – you were not engaged in science. You are engaged in making stuff up and writing it down. If you, as a publisher, are unwilling or unable to demand the data which leads to the conclusions in the papers which you publish and tacitly endorse as science, you are not, in fact, publishing science. You are letting people make some stuff up, write it down, and then hand it to you to publish with less oversight and due diligence than a fan blog about Pokémon.

It really is that simple. The problem is a general unwillingness to hold bad scientists and bad publications accountable for the crap they produce. Part of that is the political environment of academia, where actually achieving or discovering new things that has been devalued in favor of simply producing more papers. Part of that is the social environment of academia, where the idea of actually challenging someone who might be wrong is seen as a terrible breach of social boundaries.

Until that environment which is socially toxic is cleaned up with whatever flamethrower equivalent you can find, this is going to be the norm – not the exception.
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gwern branwen

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Now that's a cool dataset and analysis. It's not as good as a Scandinavian population registry but still neat.
Heritability is a fundamental characteristic of human disease essential to the development of a biological understanding of the causes of disease. Traditionally, heritability studies are a laborious process of patient recruitment and phenotype ascertainment. Electronic health records (EHR) passively capture a wide range and depth of clinically relevant data and represent a novel resource for studying heritability of many traits and conditions tha...
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Neural network all the things, apparently.
Abstract. Real-time simulation of fluid and smoke is a long standing problem in computer graphics, where state-of-the-art approaches require large compute resources, making real-time applications often impractical. In this work, we propose a data-driven approach that leverages the approximation ...
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Michael Specter on Vandana Shiva, an activist who accuses biotechnology companies such as Monsanto of imposing “food totalitarianism.” Others believe that G.M.O.s are the key to solving world hunger.
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This woman is demonstrably a self-promoting, jet-setting liar and fanatic.
It's worth reading the wikipedia article on her for more info.

"Journalist Keith Kloor, in an article published in Discover on 23 October 2014 entitled "The Rich Allure of a Peasant Champion", revealed that Shiva charges US $40,000 per speaking lecture, plus a business-class air ticket from New Delhi."
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"Predicting educational achievement from DNA", Selzam et al 2016:

"A genome-wide polygenic score (GPS), derived from a 2013 genome-wide association study (N=127,000), explained 2% of the variance in total years of education (EduYears). In a follow-up study (N=329,000), a new EduYears GPS explains up to 4%. Here, we tested the association between this latest EduYears GPS and educational achievement scores at ages 7, 12 and 16 in an independent sample of 5825 UK individuals. We found that EduYears GPS explained greater amounts of variance in educational achievement over time, up to 9% at age 16, accounting for 15% of the heritable variance. This is the strongest GPS prediction to date for quantitative behavioral traits. Individuals in the highest and lowest GPS septiles differed by a whole school grade at age 16. Furthermore, EduYears GPS was associated with general cognitive ability (~3.5%) and family socioeconomic status (~7%). There was no evidence of an interaction between EduYears GPS and family socioeconomic status on educational achievement or on general cognitive ability. These results are a harbinger of future widespread use of GPS to predict genetic risk and resilience in the social and behavioral sciences."
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"The continuing value of twin studies
in the omics era", van Dongen et al 2012:

"The classical twin study has been a powerful heuristic in biomedical,
psychiatric and behavioural research for decades. Twin registries worldwide have
collected biological material and longitudinal phenotypic data on tens of thousands
of twins, providing a valuable resource for studying complex phenotypes and their
underlying biology. In this Review, we consider the continuing value of twin studies in
the current era of molecular genetic studies. We conclude that classical twin methods
combined with novel technologies represent a powerful approach towards identifying
and understanding the molecular pathways that underlie complex traits"
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Have him in circles
2,763 people
Maria Jones's profile photo
Kyra Alex's profile photo
David Atkinson's profile photo
John Danaher's profile photo
Greg Sutliff's profile photo
Charity Dorn's profile photo
Adam Augusta's profile photo
Maire Byrne's profile photo
A Ettlinger's profile photo
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