Location: Herzstein Hall Room 210
"Synthetic Signaling Systems for Biological Discovery and Design"
Cells utilize a plethora of signal transduction pathways to shape their responses to various environmental cues and much work has been done to dissect signaling networks in this native context in order to better understand how they contribute to cellular decision making. However, it can be difficult to study the inherent properties of a specific signaling module of interest due to the multitude of confounding interactions between the module and its native environment. To obviate these challenges, we have used computational and synthetic biology approaches to construct, analyze, and perturb signaling modules ex vivo. In this talk, I will highlight findings from our work on three such systems: information processing in a kinase cascade, ribosomal initiation of protein translation, and multi-feedback regulation of receptor signaling. In all three cases, we identify novel modes of regulation that underscore the inherent flexibility of these signaling modules and elucidate biological design rules that govern the operation of these modules in native and/or synthetic contexts.
About the Speaker: Casim Sarkar received his B.S. in Chemical Engineering from the University of Texas at Austin (1997) and his Ph.D. in Chemical Engineering from the Massachusetts Institute of Technology(2002). After a postdoctoral fellowship in the Department of Biochemistry at the University of Zurich, Dr. Sarkar joined the Department of Bioengineering at the University of Pennsylvania in2006. His research interests lie in the area of molecular cell engineering, both for fundamental biological discovery and for translational design. Applications include understanding signal processing in cell decision-making, constructing synthetic circuits for rational cell engineering, and engineering biomolecules for various biomedical and biotechnological applications. Dr. Sarkar’s honors include a Fannie &John Hertz Foundation Graduate Fellowship, an NIH NRSA Postdoctoral Fellowship,and an NSF CAREER Award.
We will serve a variety of home-made/store-bought pies and hold/cold refreshments outside in the quad (where the BBQ was) - so mark your calendar! This will be the last CHBE GSA social event of the year besides the Holiday Party.
Friday, Friday - gotta' get pie on Friday!!!
No RSVP necessary.
- Charles Conn -
CHBE GSA Publicity
George Stephanopoulos (Author)
A thorough overview of all aspects of chemical process control -- process modeling, dynamic analyses of processing systems, a large variety of control schemes, synthesis of multivariable control configurations for single units and complete chemical plants, analysis and design of digital computer control systems.
download Link: http://www.mediafire.com/download.php?dsjrjhs4mjxb2qh
Transfer ownership before removing the owner account
It's Friday the 13th, so we want to work extra hard to ward off bad luck! We're so excited to see so many pages making the most of our multiple manager feature. But, say you want to remove a managing account from your page. First, check whether that account is the page's owner. If so, they'll need to transfer ownership of the page to another manager before their account is removed from the page. Otherwise, the page will be deleted instead of transferred automatically to another manager.
Take a minute, check it over, and save yourself from an unfortunate mistake!
A new paper from Rice researchers suggests that methane could have caused a massive climate change 56 million years ago. It demonstrates how huge amounts of carbon from methane hydrate, released from beneath the sea floor, could have been the element that warmed Earth and dramatically altered the ecosystem.
To successfully translate scientific advances into new cost-effective products and processes, the chemical and biomolecular engineer of the future will need a broad education that combines:
- solid grounding on science and engineering fundamentals;
- knowledge of advanced computational and experimental techniques;
- interdisciplinary skills that extend from chemistry, biology and materials science to computer science, systems modeling and environmental engineering.
This challenge shapes the research and educational missions of our department as it strives to:
- maintain outstanding undergraduate and graduate educational
programs so that our highly qualified and motivated students will
be prepared to assume leadership roles in industry, academia,
law, business, medicine and government;
- conduct basic and applied research of the highest quality that
emphasizes interdisciplinary collaboration and the development
of partnerships involving academia, industry and government; and
- serve as an educational and technological resource for the professional and scientific communities at the local, national, and international levels.
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