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#NFO: Brain Health: Brain Research And News = NeuroFerritinOpathy
#NFO: Brain Health: Brain Research And News = NeuroFerritinOpathy

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These findings have important implications for people with depression who are looking for ways to lift their mood. First, they confirm the benefit of doing more activities that bring enjoyment—and particularly of sharing positive experiences with other people.

They also underscore that depression gets in the way of being able to anticipate the mood-lifting effects of positive activities, which often leads us away from doing the very things that will help us feel better.

This tendency is exactly what behavioral activation for depression is designed to address. The structure and progressive approach of this treatment can be a real lifeline for a person who knows s/he needs to "do more," and is struggling mightily to find the wherewithal to do so. 
How can the "daily uplifts" help to lift the symptoms of depression?

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Very Interesting
Scientific Discovery May Change Treatment of Parkinson's

When monitoring Parkinson's disease, SPECT imaging of the brain is used for acquiring information on the dopamine activity. A new study conducted in Turku, Finland, shows that the dopamine activity observed in SPECT imaging does not reflect the number of dopamine neurons in the substantia nigra, as previously assumed.

The research is in Neurology. (full access paywall)

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Cell therapy is now transitioning from the world of grafts, where it has been confined for decades, to the world of products

This happened with antibodies. People used to give their blood and antibodies. Then it became possible to manufacture antibodies from cells in an industrial setting, and then it became a product. I think that we’re going in that direction with cell therapy.

In the coming decade, off-the-shelf cell therapy will become a reality. That is a revolution and is going to change a lot of things. We will need to establish standards and regulations. Cells usually have not been regarded as products, so it’s a big leap. We have to discuss with regulators how to define the products.

Tumors that succeed in the body are tumors that have found a way to evade the immune system. You need to put additional features to empower the T-cells to do what normal T-cells fail to do. People will realize the transformative power of gene editing. We think it will take over the industry.

I think globally, gene editing is going to be a strong power because we are going to be able to tweak cells like we’ve never done before. We will be able to program cells to deliver a treatment locally. This is happening. It’s not futuristic. It’s now.

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How complex is the brain?

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Until now, results have only been published from experiments in which the CRISPR technique was used in abnormal embryos, made when two sperm fertilise the same egg. The idea behind this work was that it was more ethical to test the technique on embryos that could never fully develop.

In the first attempt to fix genes in human embryos, fewer than 1 in 10 cells were successfully repaired – an efficiency rate that is too low to make the method practical. A second study published in 2016 also had a low rate of efficiency. However, because these embryos were very genetically abnormal, these experiments may not have given an accurate indication of how well the technique would work in healthier embryos.

The Chinese team behind the latest study, at the Third Affiliated Hospital of Guangzhou Medical University, first carried out experiments with abnormal embryos, and found the repair rate was very low. But they had more success when they tried to repair mutations in normal embryos derived from immature eggs donated by people undergoing IVF.

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Scientists may have a secret weapon against bacteria

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How your brain responds to stress

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What's likeliest to kill more than 10 million human beings in the next 20 years? It's probably not what you'd think.
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