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Dr. Jack Smith
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14 followers
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Dr. Jack's posts

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Drug Interactions between Nine Antifungal Agents and Drugs Metabolized by Human Cytochromes P450
This article reviews in vitro metabolic and in vivo pharmacokinetic drug–drug interactions of nine antifungal agents: six azoles (fluconazole, itraconazole, ketoconazole, miconazole, posaconazole, and voriconazole) and three echinocandins (anidulafungin, ca...

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Epigenetic Regulation of Genes Encoding Drug-Metabolizing Enzymes and Transporters; DNA Methylation and Other Mechanisms
Drug metabolizing enzymes and transporters are increasingly recognized as key determinants of the inter-individual variability in pharmacokinetic (PK) and pharmacodynamic (PD) outcomes of clinically important drugs. To date, most studies investigating this ...

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Targeting Polyamine Metabolism for Finding New Drugs Against Leishmaniasis: A Review
Leishmaniasis is a neglected disease affecting more than 12 million people worldwide. The most used drugs are pentavalent antimonials that are very toxic and display the problem of drug resistance, especially in endemic regions such as Bihar in India. For t...

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Xenobiotic Metabolism in Human Skin and 3D Human Skin Reconstructs: A Review
In this review, we discuss and compare studies of xenobiotic metabolism in both human skin and 3D human skin reconstructs. In comparison to the liver, the skin is a less studied organ in terms of characterising metabolic capability. While the skin forms the...

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Inhibitors of the HSP90 Molecular Chaperone: Attacking the Master Regulator in Cancer
The heat shock protein 90 (HSP90) chaperones represent some 1-2% of all cellular protein and are key players in protein quality control in cells. They are over expressed in many human cancers and the fact that many oncogenic proteins are clients has prompte...

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On the Structural Plasticity of the Human Genome: Chromosomal Inversions Revisited
With the aid of novel and powerful molecular biology techniques, recent years have witnessed a dramatic increase in the number of studies reporting the involvement of complex structural variants in several genomic disorders. In fact, with the discovery of C...

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