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Dr Paul Murray
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I am an experienced scientist with a proven track record of the timely delivery of innovative solutions to client projects resulting in significant reductions in costs and resources to customers.
I am an experienced scientist with a proven track record of the timely delivery of innovative solutions to client projects resulting in significant reductions in costs and resources to customers.

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Many people find DoE difficult to understand. We are going to try to explain DoE in simple terms. We will explain all the jargon and help you to understand what it can do, how it could help you and how to get the most out of it with a focus towards use in chemistry. My colleague Laura has started a series on DoE demystified. You can find more here:
https://lnkd.in/dfGD-RA

If you have any suggestions for topics relating to DoE or questions then please let us know and we will try to help.
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We will be running a 2 day training course on the use of Design of Experiments (DoE) @ the The Park Hotel, Falfield, UK on the 9th and 10th November 2016.

DoE is a statistical tool which enables the efficient exploration of potential reaction parameters and their effect on a process. The course will introduce the DoE Process and how to use it to develop and understand chemical reactions and processes.

DoE provides information about the interaction of factors and the way the total system works, something not obtainable through traditional testing methods. DoE also shows how interconnected factors respond over a wide range of values, without requiring the testing of all possible values directly. DoE is a fundamental aspect of Quality by Design.
 
The Two day course written and presented by a process chemist with extensive experience of applying DoE across a wide range of chemical reactions from reactions screening and new route development through to reaction optimisation.
 
The course will empower scientists to implement DoE in their work to more efficiently improve their processes.

http://www.catalysisconsulting.co.uk/design-of-experiments-for-chemists-and-engineers.html
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An interesting an simple way to describe Principal Component Analysis
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Design of Experiments training course for Chemists and Engineers.
I will be running a 3 day training course with Scientific Update on the use of Design of Experiments (DoE) @ the Sea Princess hotel in Mumbai - 13th to 15th April. DoE is a statistical tool which enables the efficient exploration of potential reaction parameters and their effect on a process. DoE is a fundamental aspect of Quality by Design. The course will introduce the DoE Process and how to use it to develop and understand chemical reactions and processes.
The course is aimed at chemists and engineers to help;
-          increases the efficiency of their work to solve challenging chemical problems.
-          improve the effectiveness of their work, the efficiency of their processes
-          develop new processes according to Quality by Design principals.
-          implement DoE to investigate scale up aspects of chemical processes.
For more information about the training course see: https://www.scientificupdate.co.uk/training/scheduled-training-courses/details/272-Design%20of%20Experiments.html
For more information about DoE see: http://www.catalysisconsulting.co.uk/documents/Design-Of-Experiments.pdf and http://www.catalysisconsulting.co.uk/documents/Combining-DOE-PCA.pdf
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Paul Murray Catalysis Consulting Ltd is pleased to share a new case study where the elimination of a new impurity observed during the scale-up of a catalytic reaction was enabled based on mechanistic understanding of catalytic reactions.
http://ow.ly/zNAmf
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Which Step have you reached today?
I think this needs one more step for 'I'm doing it'!
Thaks Ena for sharing ithis on LinkedIn.
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A leading pharmaceutical company needed to manufacture 60kg of an active pharmaceutical intermediate using a Suzuki reaction. The catalyst for this particular process would have cost £240,000 and the previous manufacture unexpectedly afforded less than 50% yield. We identified alternative robust reaction conditions which enabled the significant reduction in the catalyst loading reducing the catalyst cost of this process by more than £140,000 while reliably achieving more than 95% isolated yield. This case study demonstrates how the new reaction conditions were identified.
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A leading pharmaceutical company needed to manufacture 80kg of an active pharmaceutical intermediate using a Buchwald Hartwig amination reaction. The catalyst for this particular process would have cost $300,000. We identified alternative catalyst systems which reduced the catalyst cost of this process by more than $280,000. This case study demonstrates how the new catalyst system was identified by combining Design of Experiments (DoE) and Principal Component Analysis (PCA) in the development of catalytic reactions.
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A pharmaceutical company needed to manufacture 5kg of an active pharmaceutical intermediate using a Suzuki reaction. The reaction was low yielding (< 45%) with a very high catalyst loading. We identified a new, high yielding and robust process for the rapid delivery of 5 kg of the required API intermediate in 1 week by kinetic evaluation for this Suzuki reaction leading to understanding of reaction mechanism. This case study demonstrates how.
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