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Stem Cells Translational Medicine
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Bridging stem cell research and clinical trials
Bridging stem cell research and clinical trials

68 followers
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Wei Yao, MD is a professor in the School of Medicine, University of California, Davis (UC Davis), an associate director of Center for Musculoskeletal Disease in UC Davis Medical Center. One of her research focuses for the past twelve years has been on bone regenerative approaches using mesenchymal stromal cells (MSCs), including bone targeted delivery and activation of MSCs or the use of genetic modified MSCs for bone regenerative medicine.

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Human induced pluripotent stem cells (iPSCs) can be differentiated into vascular endothelial and smooth muscle cells. Hemodynamic exposure of these differentiated cells cocultured together restores normal and pathological biological responses. Thus, we demonstrate that iPSC-derived vascular cells exposed to hemodynamics may provide a viable system for modeling rare vascular diseases and testing new therapeutic approaches.

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Study Shows Stem Cell Infusion Helps Treat Severe Cases of Aplastic Anemia
This study further assessed bone marrow-derived mesenchymal stromal cells (BM-MSCs) transfusion for treatment of aplastic anemia (AA) that was refractory to immunosuppressive therapy though larger samples. The results suggest that BM-MSCs transfusion as a supplementary measure can be used to treat refractory AA. It showed the time to hematopoietic recovery of BM-MSCs transfusion for refractory AA. It also provided further data that antithymocyte globulin used in previous treatment and no activated infection were the most important predictors for response.

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