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Juvid Aryaman
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Identification of New Activators of Mitochondrial Fusion Reveals a Link between Mitochondrial Morphology and Pyrimidine Metabolism
http://www.sciencedirect.com/science/article/pii/S2451945617304282?via%3Dihub Laia Miret-Casals, David Sebastián, José Brea, Eva M.Rico-Leo, Manuel Palacín, Pedro M.Fernández-Salguero, M. Isabel Loza, Fernando Albericio, Antonio Zorzano The authors develop ...
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Pervasive within-Mitochondrion Single-Nucleotide Variant Heteroplasmy as Revealed by Single Mitochondrion Sequencing
http://www.cell.com/cell-reports/references/S2211-1247(17)31668-6 Morris J, Na YJ, Zhu H, Lee JH, Giang H, Ulyanova AV, Baltuch GH, Brem S, Chen HI, Kung DK, Lucas TH, O'Rourke DM, Wolf JA, Grady MS, Sul JY, Kim J, Eberwine J This study looks at the prevale...
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How cells adapt to progressive mitochondrial mutation
Mitochondria
produce the cell's major energy currency: ATP. If mitochondria become
dysfunctional, this can be associated with a variety of devastating
diseases, from Parkinson's disease to cancer. Technological advances
have allowed us to generate huge volu...
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Glucose feeds the TCA cycle via circulating lactate
https://www.nature.com/articles/nature24057 Sheng Hui, Jonathan M. Ghergurovich, Raphael J. Morscher, Cholsoon
Jang, Xin Teng, Wenyun Lu, Lourdes A. Esparza, Tannishtha Reya, Le
Zhan, Jessie Yanxiang Guo, Eileen White & Joshua D. Rabinowitz When oxygen is...
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Structural Basis of Mitochondrial Transcription Initiation
http://www.sciencedirect.com/science/article/pii/S009286741731262X?via%3Dihub Hauke S.Hillen, Yaroslav I.Morozov, Azadeh Sarfallah, Dmitry Temiakov, Patrick Cramer Transcription of the mitochondrial DNA is a critical aspect of understanding mitochondrial ph...
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Abrogating Mitochondrial Dynamics in Mouse Hearts Accelerates Mitochondrial Senescence
http://www.sciencedirect.com/science/article/pii/S1550413117306113 Song M, Franco A, Fleischer JA, Zhang L, Dorn II GW Mitochondrial fragmentation is often considered as harmful. This is often determined by inhibiting fusion fission proteins such as Mfn2 an...
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Inertial picobalance reveals fast mass fluctuations in mammalian cells
https://www.nature.com/articles/nature24288 David Martínez-Martín, Gotthold Fläschner, Benjamin Gaub, Sascha Martin, Richard Newton, Corina Beerli, Jason Mercer, Christoph Gerber & Daniel J. Müller Use a highly sensitive balance to measure the mass of singl...
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Live imaging reveals the dynamics and regulation of mitochondrial nucleoids during the cell cycle in Fucci2-HeLa cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595809/ Taeko Sasaki, Yoshikatsu Sato, Tetsuya Higashiyama, Narie Sasaki  Authors investigate the dynamics of mitochondrial DNA replication through the cell cycle by labelling HeLa cells with Fucci markers (a fl...
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Mitochondrial fission facilitates the selective mitophagy of protein aggregates
Jonathon L. Burman, Sarah Pickles, Chunxin Wang, Shiori Sekine, Jose Norberto S. Vargas, Zhe Zhang, Alice M. Youle, Catherine L. Nezich, Xufeng Wu, John A. Hammer, Richard J. Youle http://jcb.rupress.org/content/early/2017/09/11/jcb.201612106.long This stud...
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Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster
Rana A, Oliveira MP, Khamoui AV, Aparicio R, Rera M, Rossiter HB, Walker DW https://www.nature.com/articles/s41467-017-00525-4  Transient induction of Drp1-mediated fission for 7 days during midlife of the fruit fly D. melanogaster is sufficient to extend l...
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