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Our bodies are confused by this 21st-century world.
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Broad Institute

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Thanks to all who joined us for Heidi Rehm's Science for All Seasons talk tonight! #broadtalks
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Proponents of the so-called “hygiene hypothesis” say that being too clean changes the bacteria that live within us, making us more susceptible to allergies, asthma and other immune-related conditions. Now, a study published in the journal Cell provides more evidence that this might be true. Learn more in this TIME news story:
 
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Researchers from the Broad’s Genetic Perturbation Platform and Microsoft Research have developed a predictive model that incorporates machine learning to uncover which single-guide RNA (sgRNA) sequences are best paired with the genome-engineering tool CRISPR-Cas9 to successfully interrogate the genome. Read about it on the BroadMinded blog:
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An exceptional dog that carried the genetic mutation for Duchenne muscular dystrophy but showed no signs of the disease has pointed researchers from Boston Children’s Hospital, Broad, and University of Sao Paolo toward a potential new treatment for the condition. Read about it in the Boston Business Journal:
Boston researchers' findings are pointing to a new potential treatment for a condition that affects thousands of adolescent boys.
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The MBC Project is a new Broad/Dana-Farber research initiative that partners directly with patients to accelerate discoveries in metastatic breast cancer. The project is actively seeking men and women living with MBC who are willing to share tumor samples and clinical info. Interested? Learn more on the project website:
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If you couldn't make it to tonight's talk by Heidi Rehm,the video will be available later this week. Watch #broadtalks for the link.
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TONIGHT: Science for All Season is back w/ Heidi Rehm on "Medical Interpretation of Human Genomes," 6pm at Broad broad.io/sfas
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Broad researchers have found that asymmetrical mutational patterns on the two strands of the DNA double helix could be implicated in some cancers. Learn more on the BroadMinded blog:
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In a Q&A on the BroadMinded blog, Guoping Feng of the Broad Institute and the McGovern Institute for Brain Research at MIT talks about recent work that shows how two mutations in the same gene (Shank3) can lead to different neurobiological changes related to distinct psychiatric disorders – in this case autism and schizophrenia.
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Aleksandar Kostic, a postdoctoral fellow at the Broad, uses powerful computational approaches to study microbial populations. In a recently published interview, he talks about his work tracing the connection between gut bacteria and type 1 diabetes:
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A vast data set amassed by the Exome Aggregation Consortium, spearheaded by Broad researchers and colleagues, has helped reveal valuable insights about the disease genes at play in debilitating rare genetic disorders. Learn more in this story from The Atlantic:
A huge project unexpectedly led to a way of finding disease genes without needing to know about diseases.
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