Swine study suggests flu vaccination may sometimes backfireBy Lisa Schnirring (CIDRAP News).
August 29, 2013cidrap.umn.edu/news-perspective/2013/08/swine-study-suggests-flu-vaccination-may-sometimes-backfire Excerpt:<< During the 2009 H1N1 pandemic, Canadian researchers identified a greater risk of infection in those who had been vaccinated against seasonal flu >><< studies in the United States and other countries contradicted the Canadian findings. However, in 2010 a large study by a Canadian team put an exclamation point on the earlier findings, reporting that the risk of needing treatment for pandemic flu was 1.4 to 2.4 times greater in those who had been vaccinated against seasonal flu in the previous year.In the new study, researchers explored the phenomenon in pigs that were infected with the 2009 H1N1 virus after receiving a vaccine against H1N2 influenza. The team, headed by scientists from the US Food and Drug Administration (FDA) and the US Department of Agriculture (USDA), published its findings yesterday >><< The interaction between the vaccine and respiratory disease, called vaccine-associated enhanced respiratory disease (VAERD), has been seen before, for example with formaldehyde-inactivated respiratory syncytial virus (RSV) vaccination followed by wild-type RSV infection.The researchers vaccinated piglets that were younger than 6 months old and hadn't been exposed to flu before against H1N2 to explore whether vaccine-induced antibodies might play a role in exacerbating respiratory symptoms. They found some of the piglets got sick with severe pneumonia and had severe lung damage after they were infected with the 2009 H1N1 virus, suggesting that cross-reactive antibodies triggered by the flu vaccine made symptoms worse after infection with a different flu strain.The part of the experiments that focused on the mechanism responsible for the effect found that H1N2 antibodies in the sick pigs bound to the hemagglutinin (HA) stem rather than the HA head of the 2009 H1N1 virus, and thus weren't able to block the virus from attaching to cells. Instead, the strong cross-reactive antibodies helped the pandemic virus fuse to cell membranes, which appeared to worsen respiratory problems in the vaccinated pigs. >>
Articles and blog posts related to flu vaccine's efficacy and adverse effects:
• Vincent Racaniello. Attenuated influenza vaccine enhances bacterial colonization of mice. Virology Blog. March 12, 2014.virology.ws/2014/03/12/attenuated-influenza-vaccine-enhances-bacterial-colonization-of-mice
• Mina MJ et al. Live Attenuated Influenza Vaccine Enhances Colonization of Streptococcus pneumoniae and Staphylococcus aureus in Mice. MBio (2014) vol. 5 (1) doi:10.1128/mBio.01040-13mbio.asm.org/content/5/1/e01040-13.full
• Vincent Racaniello et al. TWiV 217: I just flu in and my arms are shot. This Week in Virology. January 27, 2013.twiv.tv/2013/01/27/twiv-217-i-just-flu-in-and-my-arms-are-shot
• Vincent Racaniello. Effectiveness of this season’s influenza vaccine. Virology Blog. January 18, 2013.virology.ws/2013/01/18/effectiveness-of-this-seasons-influenza-vaccine
• Vincent Racaniello. Friday flu shot. Virology Blog. January 11, 2013.virology.ws/2013/01/11/friday-flu-shot-2
• Vincent Racaniello. How good is the influenza vaccine? Virology Blog. November 3, 2011.virology.ws/2011/11/03/how-good-is-the-influenza-vaccine
• Katherine Hobson. Flu Shot Could Be Better, But For Now It’s The Best We’ve Got. The Wall Street Journal (blogs). October 26, 2011.blogs.wsj.com/health/2011/10/26/flu-shot-could-be-better-but-for-now-its-the-best-weve-got
• Osterholm MT et al. Efficacy and effectiveness of influenza vaccines: a systematic review and meta-analysis. The Lancet Infectious Diseases (2012) vol. 12 (1) pp. 36-44
• Gaps in evidence for effectiveness of influenza vaccines highlight need for new vaccine. Eurekalert. October 25, 2011.eurekalert.org/pub_releases/2011-10/l-gie102411.php
• Osterholm MT et al. The Compelling Need for Game-Changing Influenza Vaccines. An Analysis of the Influenza Vaccine Enterprise and Recommendations for the Future. University of Minnesota Center for Infectious Disease Research and Policy (2012)cidrap.umn.edu/cidrap/center/mission/articles/ccivi-landing.html
Video interview to leading author:
• Michael T. Osterholm (interviewee). Influenza. UPMC Center for Health Security. April 25, 2013.cidrap.umn.edu/compelling-need-game-changing-influenza-vaccines youtu.be/pt1CLKeWWZM
(8 min 50 s)
• Vincent Racaniello (interviewer) and Frederick Hayden (interviewee). Frederick Hayden on influenza antivirals.
[part of TWiV 99: TWiV at ICAAC 2010] Virology Blog. January 31, 2011.virology.ws/2011/01/31/frederick-hayden-on-influenza-antivirals youtu.be/qpk-SVzx23I
(15 min 29 s)
• Maroof A et al. Intranasal vaccination promotes detrimental Th17-mediated immunity against influenza infection. PLoS Pathog (2014) vol. 10 (1) pp. e1003875plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1003875
• Aspinall R and Lang PO. The Avalanche is Coming … And Just Now It's Starting to Snow. Front Immunol (2013) vol. 4 pp. 165journal.frontiersin.org/Journal/10.3389/fimmu.2013.00165/full
• Lenzer J. Belief not science is behind flu jab promotion, new report says. BMJ (2012) vol. 345 pp. e7856bmj.com/content/345/bmj.e7856
• Flegel K. Health care workers must protect patients from influenza by taking the annual vaccine. CMAJ (2012) vol. 184 (17) pp. 1873cmaj.ca/content/184/17/1873.long
• Flegel K. Influenza vaccination of health care workers--the author responds. CMAJ (2013) vol. 185 (2) pp. 151stm.sciencemag.org/content/5/200/200ra114.abstract
• Doshi P et al. Influenza vaccination of health care workers. CMAJ (2013) vol. 185 (2) pp. 150cmaj.ca/content/185/2/150.1.long
• Doshi MT et al. Influenza vaccination of health care workers. CMAJ (2013) vol. 185 (2) pp. 150-1cmaj.ca/content/185/2/150.2.long
the following letter is clearly biased against but it contains references to some informative studies, articles and posts. I've already included some of them in this post.
• Eisenstein M MD,JD,MPH Scientific Evidence about the efficacy and safety of flu vaccines are universal mandates on the way?library.constantcontact.com/download/get/file/1101240076659-1471/EFFICACY+AND+SAFETY+OF+FLU+VACCINES.pdf Excerpt from comments of related G+ post:Zephyr López Cervilla
Mar 15, 2014 4:39 AM
I'm not vaccinated for measles either. I have personally nothing against vaccines. In fact, some years ago I visited 3 times a healthcare center to get 3 shots of the Hepatitis A and B vaccine. But now I don't feel like to get the MMR vaccine, I simply avoid being exposed to people suspicious to carry a contagious disease, and not weakening my immune system (e.g., by sleep deprivation, chill, zinc, or vitamin D deficiency).
When I was a kid my family didn't want me to take the MMR shot, I don't know the exact reason, they vaccinated me of other diseases such as polio. Perhaps the MMR didn't have a good reputation back then, or perhaps they considered the MMR to be rather useless. But this is just my lucubration.
BTW, I'm certain that a few of my classmates back then or their siblings got infected with measles or mumps, and quite probably they had been vaccinated (possibly I was the only who hadn't been vaccinated in my class), so as someone said above, the measles vaccine isn't very effective either.
A few years ago I recommended my old mother to get a shot of the seasonal flu vaccine. The resulting effects of the immunisation made her feel ill for a few days. She hasn't gone to have another shot since then (her own initiative). Anyway, she's never passed the flu, or she's never experienced its symptoms, so why worry? If they ever commercialise an effective and long-lasting flu vaccine perhaps I'll recommend it to her.Suzanne Roberts
Mar 15, 2014 5:47 AM +1
+Zephyr López Cervilla two things - herd immunity and carriers.
Herd immunity is what protects us (no vaccine can be 100% effective, but the more people in the community that ARE vaccinated, the less chance of spreading the disease.
Carriers - persons who have been exposed to a virus do not always exhibit symptoms...do you want to risk infecting a child, an elderly person, someone who is immuno-deficient? I certainly don't.
In your mother's case, it is certainly possible that the vaccine was for a different mutation of influenza, or that her symptoms were caused by something other than influenza, like a norovirus.
People seem to forget that influenza (and other vaccine-preventable diseases) caused hundreds of thousands of deaths worldwide.Zephyr López Cervilla
Mar 15, 2014 8:31 AM
+Suzanne Roberts: "two things - herd immunity and carriers."
Two things too. First, you aren't telling me anything I haven't heard before. I took a couple of courses of immunology while in college (in addition to the lessons of immunology in human physiology and in some other subjects).
Second, for some reason you have assumed that I care enough the health of anonymous others to the point I'll get shots that will probably never help me.
As for my mother, why should she bother to get any flu vaccines? they won't make her feel any better but rather the other way around. She must have been already exposed to influenza viruses in hundreds of occasions in the past, if hasn't passed the flu so far she won't probably get the disease unless her health deteriorates significantly, but at that point, all her previous years' flu shots won't make her any good either.Edit:
it seems the year after that flu shot she caught a cold particularly bad, something unusual to her and that she attributes to the vaccine. It may well be that that was actually a flu and not a cold, and that her atribution to stronger symptoms to her vaccination isn't actually far fetched:
• Lisa Schnirring. Swine study suggests flu vaccination may sometimes backfire. CIDRAP News. Aug 29, 2013.cidrap.umn.edu/news-perspective/2013/08/swine-study-suggests-flu-vaccination-may-sometimes-backfire
On the other hand, I can't feel the difference between a flu or a cold either, so I have no intention to take any flu shots either. And as for the peace of mind of those who are public health-conscious, fuck them all.
If you really want to cut down the spread of contagious diseases then you should advocate against herding kids in daycare centres and schools. Those centres work as bioreactors, allowing to grow and recombine different strains of contagious diseases that then they will spread to their families (including the elderly great-grandpas and grandmas).
I don't mean that children should never socialise with other kids, the problem arises when you put hundreds or even a thousand kids in the same building or concentration camp for 6-8 hours a day 9 months a year. Considering how scrupulous children are with their personal hygiene it'd take a miracle that they didn't propagate to others any contagious disease, fleas, lice, worms, or whatever else they may have caught.
+Suzanne Roberts: "do you want to risk infecting a child, an elderly person, someone who is immuno-deficient? I certainly don't."
— I am certainly more concerned of the risk of becoming infected from others. Contagious diseases usually come from someone else.
If nobody infects me I won't infect an elderly person. I try to avoid contact with children (as I said above children are primary carriers for contagious diseases) so I have hardly any chance to infect a child.
+Suzanne Roberts: "it is certainly possible that the vaccine was for a different mutation of influenza, or that her symptoms were caused by something other than influenza, like a norovirus."
— You seem not to have got it. She didn't pass the flu, those were the typical symptoms caused by the effects of the vaccination. The real flu also causes other symptoms like cough, runny nose and lasts longer than two days. As for noravirus, that usually causes gastroenteritis, and those weren't her symptoms. In addition, the timing was perfect, and she rarely feel ill. If you want I can find you to a recording with the description of the symptoms experienced after a flu shot by a reputed virologist.
+Suzanne Roberts: "People seem to forget that influenza (and other vaccine-preventable diseases) caused hundreds of thousands of deaths worldwide."
— As I said above, I don't are much about that. People are going to die one way or another, if not by disease, by wars or by their own stupidity. Granted, they are entitled to take care of themselves and their health but don't ask me to make sacrifices to help others that I don't even know. The only reason I would consider to get a vaccine is to protect myself, that's why I got the hepatitis vaccines.___________
URL source G+ post: plus.google.com/+BetsyMcCall/posts/FX1zy7SfiY4 ________________________