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Researchers Illuminate Key Role of NOX Proteins in Liver Disease
Study adds credence to new treatment approach now in clinical trials

Researchers at the University of California, San Diego School of Medicine have demonstrated a direct connection between two signaling proteins and liver fibrosis, a scarring process underlying chronic liver disease, the 12th leading cause of death in the United States.

The finding adds further credence to a current pharmaceutical effort to create new treatments for diabetic nephropathy, liver fibrosis and other progressive fibrotic and inflammatory diseases, based on blocking these two molecules, both members of the NADPH (nicotinamide adenine dinucleotide phosphate) oxidase (NOX) family of proteins. Read more here http://health.ucsd.edu/news/releases/Pages/2015-07-29-nox-protein-and-liver-disease.aspx #fibrosis #liver #ucsdresearch #medicine  
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“La Jolla Institute’s mission has always been to better understand the human immune system and develop new treatments, cures and prevention of diseases ranging from cancer and diabetes to both old and emerging infectious agents, like tuberculosis, dengue virus and SARS,” said Mitchell Kronenberg, PhD, president and chief scientific officer of LJI. “Working more closely with UC San Diego Health and its renowned faculty in the biological sciences will help get us there faster.”   

The affiliation will provide translational aspects of the fundamental research performed at LJI, ultimately benefitting real people with real health care needs, said Paul Viviano, chief executive officer of UC San Diego Health. “UC San Diego and the La Jolla Institute have a long history of collaboration. Our scientists and physicians work well together. This agreement strengthens those connections, drawing closer LJI with UC San Diego’s nationally esteemed programs in the biological sciences. The result will be new treatments more quickly debuting in our health system, providing patients with the best, most advanced health care possible. It is the sort of thing that happens only in an academic health system.” #immunology #infectiousdisease #pharmacology #affiliations #researchbusiness  
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The National Center for Advancing Translational Sciences, part of the +National Institutes of Health (NIH), has awarded James McKerrow, MD, PhD, director of the University of California, San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences, with a 2015 New Therapeutic Uses Award. The grant will provide McKerrow and his team with SAR114137, a chronic pain drug owned by Sanofi, and support for testing the drug’s efficacy in treating Chagas disease, a parasitic infection that is the leading cause of heart failure in Latin America.
Read more about how McKerrow will repurpose the drug here: http://health.ucsd.edu/news/releases/Pages/2015-07-23-NIH-and-UC-San-Diego-Repurpose-Sanofi.aspx.
#health #medicine #research #UCSD #Chagas  
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Tapping the potential of metabolomics, an emerging field focused on the chemical processes of metabolism, researchers at University of California, San Diego School of Medicine have identified a new and pivotal player in diabetic kidney disease. The research team has also discovered a new, and potentially better, biomarker for diagnosing and monitoring chronic diabetic kidney disease.

Read more about the this research here: http://health.ucsd.edu/news/releases/Pages/2015-07-22-Metabolomics-Reveals-Key-Player-in-Diabetic-Kidney-Disease.aspx.
#kidney #health #medicine #research #UCSD  
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Thanks to the extraordinary efforts of our team to provide superior clinical care, once again, UC San Diego Health and its hospitals are ranked #1 in San Diego, and recognized among the best in the nation, by +US News & World Report  for 2015-16. The annual U.S. News “Best Hospitals” rankings distinguish hospitals that excel in treating the most challenging health conditions.

UC San Diego Health ranked in Cancer, Cardiology and Heart Surgery, Diabetes and Endocrinology, Ear, Nose & Throat, Gastroenterology & GI Surgery, Geriatrics, Gynecology, Nephrology, Neurology & Neurosurgery, Orthopedics, Pulmonology and Urology.

Read more at http://health.ucsd.edu/news/releases/Pages/2015-07-20-us-news-rankings-best-hospital.aspx.
#healthcare #health #medicine #UCSD  
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Research provides new insights into glioblastoma’s ability to overcome chemotherapy

Tumors can leverage glucose and other nutrients to resist targeted therapies directed at specific cellular molecules, according to researchers at University of California, San Diego School of Medicine and Ludwig Cancer Research. In the study, published this week in Proceedings of the National Academy of Sciences, the team used human tissue and mouse models to demonstrate that nutrients can strongly affect the signaling molecules that drive tumors in glioblastoma, a deadly brain cancer.

"This study shows that metabolic and nutritional factors might be quite important in cancer development and treatment," said co-senior author Paul Mischel, MD, professor of pathology at UC San Diego School of Medicine and Ludwig San Diego member. Mischel led the study with Webster Cavenee, PhD, Distinguished Professor of Medicine at UC San Diego School of Medicine and Ludwig San Diego member.  #cancer #neurology #cancerresearch #ucsdresearch  
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Researchers at University of California, San Diego School of Medicine have established the safety and dosing of a new drug for treating blood cancers. The findings are published online July 27 in The Lancet Haematology.

The drug is a small molecule inhibitor that suppresses the activity of a signaling pathway believed to contribute to a variety of blood cancers’ eventual resistance to standard chemotherapy treatments.  

More specifically, preclinical research, funded in part by the California Institute for Regenerative Medicine (CIRM), has shown that the drug coaxes dormant cancer stem cells, residing in the bone marrow, to begin differentiating and exit into the blood stream where they can be destroyed by chemotherapy agents targeting dividing cells.
#cancerresearch #bloodcancers #leukemia #ucsdresearch #stemcells  
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Court Rules UC San Diego is Rightful Owner of Alzheimer’s Disease Cooperative Study Data - Decision indicates strength of overall case
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Precedent case for investigators..the University owns you !  Very bad for incentives, 
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A new study by researchers at University of California, San Diego School of Medicine reveals a protein’s critical – and previously unknown -- role in the development and progression of acute myeloid leukemia (AML), a fast-growing and extremely difficult-to-treat blood cancer. The finding offers a novel target for better treating AML, and possibly other cancers, by cutting off the ability of tumors to access nearby cellular players that feed its growth.

Read more about this finding here: http://health.ucsd.edu/news/releases/Pages/2015-07-23-Protiens-role-in-acute-myeloid-leukemia.aspx.
#cancer #AML #leukemia #research #UCSD #medicine  
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Roughly 20 to 30 percent of patients with hepatitis C virus (HCV) are also infected with human immunodeficiency virus type 1 (HIV). Both blood-borne viruses share the same modes of transmission, but many HCV medications currently have significant limitations due to adverse interactions with HIV treatments. Researchers at University of California, San Diego School of Medicine report a new combination that effectively treats HCV in patients co-infected with HIV. Read more about this new drug combination here: http://health.ucsd.edu/news/releases/Pages/2015-07-21-New-Drug-Combo-Treats-people-with-HepC-and-HIV.aspx.
#HIV #health #medicine #Hepatitis #UCSD #research  
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UC San Diego Health and AccentCare have created a jointly owned home health services agency to serve UC San Diego Health patients in San Diego and surrounding communities. The new agency is designed to provide a comprehensive continuum of care after patients have been discharged from the hospital to facilitate efficient communication, improved safety, and faster healing. Read about what this affiliation will mean for patient care and experience here http://health.ucsd.edu/news/releases/Pages/2015-07-14-accentcare.aspx
#patientcare #healthcare #quality #ucsandiegohealth  
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From the smell of flowers to the taste of wine, our perception is strongly influenced by prior knowledge and expectations, a cognitive process known as top-down control. In a University of California, San Diego School of Medicine study, a research team led by Takaki Komiyama, PhD, assistant professor of neurosciences and neurobiology, reports that in mouse models, the brain significantly changed its visual cortex operation modes by implementing top-down processes during learning. Read more here http://health.ucsd.edu/news/releases/Pages/2015-07-13-learning-impacts-vision.aspx #neuroscience #psychiatry #neurobiology #ucsdresearch  
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Introduction

UC San Diego Health is widely recognized as one of the premier health care systems in the United States. We’re the only academic health system in San Diego. It’s the one place that can offer you and your family medical treatments not available elsewhere in the region. And we don’t just treat disease – we treat you.

UC San Diego Health is consistently ranked among the nation’s best hospitals in U.S. News & World Report, and number 1 in San Diego in the magazine’s first-ever metro rankings in 2011. We were honored as one of the top 15 teaching hospitals in the country by Thomson Reuters in 2010.

Our physicians – who number more than 850 – are acknowledged as leaders in their fields of medicine and surgery. In 2014 UC San Diego had 110 physicians in 40 specialties named “Top Docs” by members of the San Diego County Medical Society as the best physicians in the region.

UC San Diego Health is part of University of California, San Diego Health Sciences. In just over four decades, we have gained international recognition as the one place where discoveries are delivered – bringing breakthroughs from the research laboratory bench to our patients’ bedsides.