“Since the loop has been found to be a key segment in prion protein aggregation, this site could be targeted for the development of new therapeutics designed to block prion conversion,” said Christina Sigurdson, DVM, PhD, associate professor at UC San Diego and UC Davis and senior author of the study. Read more here https://health.ucsd.edu/news/releases/Pages/2015-02-23-human-prion-protein-and-chronic-wasting-disease.aspx #infectiousdiseases #prions #ucsdresearch
“This program is the first of its kind,” said JDP co-director Steffanie Strathdee, PhD, professor and head of the UC San Diego Global Health Initiative. “Given that substance use has a growing health and societal impact in the U.S. and globally, this program could not come at a better time.”
#ucsd #sdsu #publichealth #substanceabuse
The researchers studied a set of well-known autism mutations called copy number variants or CNVs. They investigated when and where the genes were expressed during brain development. “One surprising thing that we immediately observed was that different CNVs seemed to be turned on in different developmental periods,” said Iakoucheva. Read more here https://health.ucsd.edu/news/releases/Pages/2015-02-18-austism-genes-and-fetal-development.aspx #autism #neurology #pediatrics #ucsdresearch
An international team of scientists, led by researchers at the University of California, San Diego School of Medicine, has identified the microtubule-associated protein tau (MAPT) gene as increasing the risk for developing Alzheimer’s disease (AD). The MAPT gene encodes the tau protein, which is involved with a number of neurodegenerative disorders, including Parkinson’s disease (PD) and AD. These findings provide novel insight into Alzheimer’s neurodegeneration, possibly opening the door for improved clinical diagnosis and treatment. Read more here https://health.ucsd.edu/news/releases/Pages/2015-02-17-mapt-gene-and-alzheimers-disease.aspx #alzheimersdisease #parkinsonsdisease #genetics #neurology #ucsdresearch
“It is an honor for the Movement Disorder Center to be recognized by the National Parkinson’s Foundation. The program at UC San Diego Health System was intentionally modeled after the center of excellence vision because of its comprehensive patient-centered focus,” said Irene Litvan, MD, Tasch Endowed Professor in Parkinson’s Disease Research and director of the Movement Disorders Center at UC San Diego Health System. “UC San Diego is recognized for diagnosing Parkinsonian disorders accurately, and early on, while providing personalized state-of-the-art care to each patient.” https://health.ucsd.edu/news/releases/Pages/2015-02-26-center-for-excellence-parkinsons-disease.aspx
#parkinsonsdisease #neurology #ucsdhealthsystem
Writing in the February 25 online issue of Nature, an international team of scientists, headed by researchers at the University of California, San Diego School of Medicine, report finding new links between inflammation and regeneration: signaling pathways that are activated by a receptor protein called gp130. “We found that gp130 is capable of activating several signaling pathways that turn on a number of transcription factors known to have a key role in stem cell biology,” said the study’s lead author, Koji Taniguchi, MD, PhD, assistant project scientist in the Department of Pharmacology at UC San Diego. #cancer #ibd #stemcells #ucsdresearch
“This study is important because it reveals a root cause of type 2 diabetes,” said Jerrold M. Olefsky, MD, professor of medicine, associate dean for scientific affairs and senior author of the study. “And now that we understand that LTB4 is the inflammatory factor causing insulin resistance, we can inhibit it to break the link between obesity and diabetes.” Read more here https://health.ucsd.edu/news/releases/Pages/2015-02-23-type-2-diabetes-and-obesity-molecular-link.aspx
#type2diabetes #obesity #ucsdresearch
“Most malaria vaccine approaches are aimed at preventing humans from becoming infected when bitten by mosquitos that carry the parasite,” said Joseph M. Vinetz, MD, professor of medicine and senior author of the study. “Our approach is to prevent transmission of the malaria parasite from infected humans to mosquitoes. This approach is similar to that of the current measles vaccine, which is such a hot topic of discussion these days, because the goal is to generate herd immunity in a population. We think that this approach is key to global malaria elimination, too.” Read more here https://health.ucsd.edu/news/releases/Pages/2015-02-18-malaria-vaccine-produced-from-algae.aspx #vaccines #malaria #ucsdresearch
Two of these studies, led by researchers at University of California, San Diego School of Medicine and Ludwig Cancer Research, address the differences between chromosome pairs (one inherited from mom, the other from dad) and how chromosome folding influences gene expression.
“Both of these studies provide important considerations for clinicians and researchers who are developing personalized medicines based on a patient’s genomic information,” said Bing Ren, PhD, professor of cellular and molecular medicine at UC San Diego, Ludwig Cancer Research member and senior author of both studies. Read more here https://health.ucsd.edu/news/releases/Pages/2015-02-18-insight-into-3D-genome-organization.aspx #cancer #epigenetics #stemcellsresearch #ucsdresearch
“Understanding the timing and pattern of cellular changes leading to retinal ganglion cell death in glaucoma should facilitate the development of tools to detect and slow or stop those cellular changes, and ultimately preserve vision,” said Andrew D. Huberman, PhD, assistant professor of neurosciences, neurobiology and ophthalmology. Huberman co-authored the study with Rana N. El-Danaf, PhD, a postdoctoral researcher in his lab. Read more here https://health.ucsd.edu/news/releases/Pages/2015-02-11-glaucoma-early-retinal-changes.aspx #ophthalmology #glaucoma #ucsdresearch
UC San Diego Health System is widely recognized as one of the premier health care systems in the United States. We’re the only academic health system in San Diego. It’s the one place that can offer you and your family medical treatments not available elsewhere in the region. And we don’t just treat disease – we treat you.
UC San Diego Health System was ranked among the nation’s best hospitals in the 2011-2012 issue of U.S. News & World Report, and number 1 in San Diego in the magazine’s first-ever metro rankings in 2011. We were honored as one of the top 15 teaching hospitals in the country by Thomson Reuters in 2010.
Our physicians – who number more than 850 – are acknowledged as leaders in their fields of medicine and surgery. In 2011, nearly 130 of our doctors were named by members of the San Diego County Medical Society as the best physicians in the region.
UC San Diego Health System is part of University of California, San Diego Health Sciences. In just over four decades, we have gained international recognition as the one place where discoveries are delivered – bringing breakthroughs from the research laboratory bench to our patients’ bedsides.