Biology and machines, is there really a difference? Here we look at DNA computation regarding DNA robotics. DNA nanobots have been injected into a cockroach.

Ars Technica: "DNA-based nanotechnology has been around for more than 30 years, but it really took off in 2006, when DNA origami was featured on the cover of Nature. This form of origami, the folding of DNA into 2D and 3D shapes, was more of an art form back then, but scientists are now using the approach to construct nanoscale robots." http://arstechnica.com/science/2014/04/dna-based-logic-gates-operate-inside-cockroach-cells/

Live Science: "Such tiny robots could do everything from target tumors to repair tissue damage."

Live Science: "There are still a few questions that need to be answered, such as how many nanomachines are needed in a given space, Douglas said. A lot of work in other animals is also needed before these nanobots get to the clinic." http://www.livescience.com/44704-nanobots-injected-into-cockroaches.html

Gizmodo: "We already have the potential to reconfigure DNA into itty bitty bio-computers programmed to do our bidding. But now scientists have used high numbers of those nanobots to successfully complete logic operations inside of actual, living organisms." http://www.gizmodo.com.au/2014/04/dna-nanobots-turn-cockroaches-into-living-8-bit-computers/

PopSci: "The nanobots can interact with one another, and were shown to be able to perform simple logical operations, for example releasing a molecule stored within upon command." http://www.popsci.com/article/science/nano-robots-compute-dna-installed-living-cockroach and http://www.businessinsider.com/dna-based-nanobots-inserted-in-a-cockroach-2014-4

Discovery: "Bioengineers have successfully injected them with nanorobots made from DNA that can unfold to dispense drugs." http://news.discovery.com/tech/robotics/cockroaches-injected-with-dna-nanobots-140409.htm

Nature: "Biological systems are collections of discrete molecular objects that move around and collide with each other. Cells carry out elaborate processes by precisely controlling these collisions, but developing artificial machines that can interface with and control such interactions remains a significant challenge. DNA is a natural substrate for computing and has been used to implement a diverse set of mathematical problems, logic circuits and robotics. The molecule also interfaces naturally with living systems, and different forms of DNA-based biocomputing have already been demonstrated. Here, we show that DNA origami can be used to fabricate nanoscale robots that are capable of dynamically interacting with each other in a living animal." http://www.nature.com/nnano/journal/vaop/ncurrent/full/nnano.2014.58.html

DVICE: "Once you get past the fact that this research involves cockroaches, the concept is pretty cool: this is the first time nanocomputers have operated inside a living creature. They're not computers in the traditional sense: rather, they're folded-up strands of DNA that can interact with each other and their environment, which in this case, is the inside of a cockroach." http://www.dvice.com/2014-4-9/dna-computers-run-inside-cockroaches-deliver-drugs

New Scientist: "It's a computer – inside a cockroach. Nano-sized entities made of DNA that are able to perform the same kind of logic operations as a silicon-based computer have been introduced into a living animal." http://www.newscientist.com/article/dn25376-dna-nanobots-deliver-drugs-in-living-cockroaches.html#.U0aAbZXnhkg

See also: http://wyss.harvard.edu/viewpressrelease/150/cloaked-dna-nanodevices-survive-pilot-mission and this S45 post: http://goo.gl/th9QVx

#nanobots #geneticengineering #biomolecularengineering #DNA #DNAorigami #biocomputing #robots #robotics #molecularbiology #biology #convergence #engineering #computing #nanotechnology #synbio #nanomachines  
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