"Unlikely" was probably a poor word choice on my part as I hadn't actually looked at compatibility charts.
What I can say with certainty is that inserting non-trivial content with CSS is a failure of accessibility:
I also assume that parsing CSS content is a configurable option which means it might not be read even if it's supported by the UA.
In the example above, I'd argue that "issue numbers" are probably non-trivial therefore a bad candidate for CSS content.
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