Full article at http://neurosciencenews.com/peripheral-neuropathy-SARM1-1987/.
New research highlights how nerves - whether harmed by disease or traumatic injury - start to die, a discovery that unveils novel targets for developing drugs to slow or halt peripheral neuropathies and devastating neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis (ALS).
The research is in Science. (full access paywall)
Research: "SARM1 activation triggers axon degeneration locally via NAD+ destruction" by Josiah Gerdts, E.J. Brace, Yo Sasaki, Aaron DiAntonio, and Jeffrey Milbrandt in Science doi:10.1126/science.1258366
Image: Axon degeneration (top), caused by nerve injury or disease, depletes the energy supply within axons, shutting down communication between nerve cells. Washington University scientists blocked axon degeneration by supplementing neurons with a chemical called nicotinamide riboside, which kept the axons energized and healthy (bottom). The image is for illustrative purposes only. Image credit: Milbrandt lab.
#neuroscience #neuropathy #neurology
First release of Snappy for amd64 and BeagleBone Black, as well as Ubuntu for phones.
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