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Friends, we need your help!

Many of you know +Konstantin Lamanov —well known on Google+ in his own right and the creator of a popular series of G+ pages.

Konstantin’s mother, Tatyana Makovoz, is seriously ill with cancer in Ukraine, and the family has exhausted its financial resources in helping her. That’s where we come in—and we’re hoping you’ll join us in contributing to raise funds. Between us, we have tens of thousands in our circles. It shouldn’t be too hard to reach our goal of $10,000. Please share this post and donate —no amount is too small to help.

To contribute:

From the G+ Pages Team:
+Rajini Rao +Margie D Casados +Rich Pollett +Annette Marin +Adarsh vijay +Rahul Roy +Alex Anderson +Milad Farjadian +Alexander Panov +Sergei Agarkoff +Andrew Obrazcov +Светлана Свет +Peter Lindelauf
Konstantin Lamanov's profile photoLeo Lang's profile photoVinod Pandey's profile photoRahul Roy's profile photo
Thanks for the shares! ♥
+Peter Lindelauf , thanks for your help. You can thank me after we figure out a way to help our friend in need :)
+Drew Sowersby Thank You for recomendation
My Mom's diagnosis:
peritoneal carcinomatosis
multiple mts in liver
4 mts in the pleura
fluid in the pleura 0.5-0.9 liters.

What may You to recomend in such case?
She eats vegetables, fruits, some meat ( strongly recommended by doctors) . Nothing special...
+Rajini Rao as you know, both my parents got cancer last year, however, after reading up on Tatyana's situation, they are not comparable. Many cancers (tumors especially) cannot survive without glucose over normal cells (but metastasis complicates this). Why. Well think about the dynamics. A stationary tumor enlarges and will require increases in energy (ie glucose). Normal cell tissue can easily outcompete a large tumor that must transport glucose to the central region. But if glucose is in excess, there is enough for all cells plus some which is one reason why so many people are overweight.

She should not have an ounce of cooked food or meat. She needs every bit of her defenses to battle this thing, not fighting toxins that normal people can deal with more easily. Reduce fruits significantly to avoid extra acids in the blood.
+Konstantin Lamanov Sorry to hear about your mother. I'm another cancer researcher offering help. I don't know what I can do to help other than offer any assistance in reading medical images. If you have questions about therapy, send me a private message and I'll check with my colleagues in oncology. Unfortunately, being in the Ukraine, I can't help your mother get into any clinical trials here. Best wishes.
Thanks for all the reshares, everyone. 33 now.
Thank you for sharing your thoughts, +Monika Ljubičić ! We should stay hopeful because some people do care and we are seeing their support in words and action. You are right about some of the What's Hot posts, though. {Hugs}
Sorry to hear you're not doing well, +Monika Ljubičić. I'm not having a very good day myself--also for medical reasons. But the sun is shining and I'm glad to join in the effort to help Konstantin. I hope you are back on your feet soon.
Jokes aside, gardening is therapeutic. It can be a form of meditation even for those not formally trained in meditation.
Hi +Rajini Rao I will happily share this as well as I know +Konstantin Lamanov by now and your backing is solid enough for me. What I would do though is inform people of the link between you and +Konstantin Lamanov to make it as clear as possible.
I noticed at least one person on a share by Konstantin talking about internet scams and we want to avoid that.
I love yours good big heart +Rajini Rao I wiped my comment, because I thought who am I to share the lessons of others.

When I started to fight with my illness I wrote this to our Kosta :) +Konstantin Lamanov (Informed us about their situation 18 05)
I was helpless and did not know what to do. And a big thank you to this idea. May God bless you Rajini!!!
I repeat the words of encouragement, dear friend from my heart:
Do not stand in sorrow Kosta!!!! You are 1,000 winds that blow, diamond that glints on snow, sun on ripened grain, gentle autumn rain. You are the soft star that shines at night!!! When you awake tomorrow in the morning's hush we all will be quiet birds in circled of light for you. All of us: Rajini and over 59 people who share this :)
much love for you and mama
Thanks, +Max Huijgen . I should note that I reached out to Konstantin when I noticed his long absences from G+ a while ago. That was when he told me of his mother's illness and the family's struggle. I offered to help with fund raising via G+, that's how this effort got started.
+Konstantin Lamanov Костя, данные на страничке фундрайзинга правильные? Можно подсунуть их WU и отправлять?
Thanks for the link to the limited share +Konstantin Lamanov Sorry that I missed it at that time. For those of you who can´t read it, it´s a very understated post which shortly describes the family sorrow and informs about the ways to organize a donate like action as we now see.
+Drew Sowersby: "Reduce fruits significantly to avoid extra acids in the blood."

- I regret to dissent with that. Despite the acid content of many fruits, the metabolization of most of them (and most vegetables saved cereal grains as the major group) doesn't contribute to acidify the organism but to alkalinize it:

1. <<Sulfur-containing amino acids in protein-containing foods are metabolized to sulfuric acid. Animal foods provide predominantly acid precursors; dietary animal protein intake is highly correlated with renal net acid excretion (r = 0.84, P < 0.0005) (9). In contrast, vegetables and fruit contain not only amino acids but also substantial amounts of base precursors; the metabolism of organic potassium salts (citrate, malate, and gluconate) in fruit and vegetables yields potassium bicarbonate (10).>>

- Sellmeyer DE et al. A high ratio of dietary animal to vegetable protein increases the rate of bone loss and the risk of fracture in postmenopausal women. Study of Osteoporotic Fractures Research Group. Am J Clin Nutr (2001) vol. 73 (1) pp. 118-22  -----------------------

2. <<The intake of 'acid' is a way of everyday life, and it is known that animal proteins and cereals are rich sources of H3PO4 and H2SO4 and are recognised as 'acid-ash' foods (Barzel & Massey, 1998; Heaney, 1998). The net production of acid is related to nutrition, and there is a gross quantitative relationship between the amount of acid produced (as reflected by urine pH) and the amount of acid-ash consumed in the diet. When one considers the extent of loss, if 2mEq Ca/d is required to buffer about 1mEq fixed acid/d, over 10 years (and assuming a total body Ca of approximately 1 kg), this requirement would account for a 15 % loss of inorganic bone mass in an average individual (Widdowson et al. 1951). Thus, consideration of a diet consisting of large quantities of fruit and vegetables (hence favouring 'alkaline-ash') may be important for bone health maintenance (Barzel, 1995).>>

- New SA. Nutrition Society Medal lecture. The role of the skeleton in acid-base homeostasis. Proc Nutr Soc (2002) vol. 61 (2) pp. 151-64 -----------------------

3a. <<Phosphate is considered to be the major dietary source of acid [2]. Many foods in the modern diet are considered detrimental to bone health, under the acid-ash hypothesis, due partially to their phosphate contents. These foods include meats, fish, dairy products [2,5-10], and grains [3,4,10], as well as many processed foods [3,4,10]. In contrast, this hypothesis posits that sodium is protective of bone health, which is not in agreement with concerns that sodium may compete with calcium for resorption in the kidney, and thus may compromise calcium metabolism and bone health [11,12]. The foods that are considered to protect skeletal mineral under this hypothesis are fruit and vegetables since these foods supply organic molecules that are metabolized to bicarbonate and therefore are considered "alkaline" [2-4,10,13,14].

Although the acid-ash hypothesis has been widely accepted and broadly stated as the major modifiable risk factor for bone loss in well cited scientific papers [4,15], as well as textbooks [16], reference works [17,18], and lay literature, this hypothesis has not been subjected to critical review. Inspite of the lack of critical review, this hypothesis is heavily promoted to the public via the internet and other advertising for commercial gain, promoting products related to an alkaline diet.>>

- Fenton TR et al. Phosphate decreases urine calcium and increases calcium balance: a meta-analysis of the osteoporosis acid-ash diet hypothesis. Nutrition Journal 2009 8:41 (2009) vol. 8 pp. 41

There may be other reasons to avoid some fruits and other sour foods in the diet of patients under chemotherapy considering that many of them have difficulty in eating (perhaps it may contribute to stomach uneasiness), but their capacity to acidify blood isn't one of them.

As for the health of Ms. Tatyana Makovoz, I hope that her treatment will be successful and she can overcome such a grave disease.
I'd suggest sharing this post again after a few weeks in case of not having raised enough funds.

Further reading:

3b. <<The acid-ash hypothesis posits that meats, grains and dairy products are detrimental to bone health due to their phosphate contents [16,3,4,10], however, this meta-analysis revealed that higher dietary intakes of phosphate do not increase either urinary calcium excretion or whole body calcium loss. Further to question the acid ash hypothesis, the evidence regarding higher net acid excretion from changes in dietary protein type or amount does not support the hypothesis [20]. No studies have evaluated the effect of grain foods on bone health. Dairy products, an important source of dietary phosphate, are also an important dietary calcium source [80] and an inexpensive source of high quality protein. Protein has been found to be supportive of bone health in a prospective cohort study and a randomized controlled trial [77,78]. Considering that this study has not upheld the concept that higher intakes of phosphate are detrimental to bone mineral maintenance, the consideration of meats, grains and dairy products as detrimental to bone health on the basis of their phosphate content must be questioned. Additionally, these foods that produce acid on metabolism are important sources of nutrients that are important for bone health, including calcium [81] (dairy products), protein [82,83] (dairy products and meats), and vitamin D [84] (some dairy products).>>

- Fenton TR et al. Phosphate decreases urine calcium and increases calcium balance: a meta-analysis of the osteoporosis acid-ash diet hypothesis. Nutrition Journal 2009 8:41 (2009) vol. 8 pp. 41
+Zephyr López Cervilla , thank you for your comments and your generous contribution! Acid-base balance is a complex topic indeed and the kidneys counter the effect of food to keep blood pH constant. As a result, urine pH of a vegetarian is alkaline and of a heavy meat eater, acidic.

All this may be moot when it comes to the cancer cell. I have a colleague (Raul Martinez-Zaguilan) who shows that cancer cells can recruit the proton pumping V-ATPase to the cell membrane to generate microdomains of acidity which help in cancer cell migration and metastasis. Similarly glucose metabolism is a mine field of complexity in terms of cancer management.

So, thanks to both you and Drew for giving us some "food for thought". I'm going to look at the references you've cited and try to digest your detailed post :)
+Rajini Rao, sure, tumor cells can also induce metabolic acidosis due to their highly increased glycolytic metabolism. This acidotic effect can represent a serious concern as those cells proliferate and consume more nutrients.

Certainly, the diet management of cancer patients may be a complex issue, especially in certain stages of the disease. Besides, for certain conditions nutritional supplements and especial nutritional strategies are often used as part of the treatment or mitigate the harming effects caused by the disease, such as the associated muscle wasting and protein loss.

As for the effect of the diet on the acid-base balance, according to a widely accepted theory in Physiology, there are homeostatic mechanisms to keep pH within a narrow range. One of those mechanisms is responsible of the wider changes in the pH urine to counterbalance the effect of the nutrients catabolized while keeping the inner pH in that narrow range.

My anecdotal evidence corroborates that general theory. Always that I've measured the pH of my urine this was above 8 (and with no signs of bacteriuria). I'm not even on a vegetarian diet since I sometimes also eat fish, seafood and often dairy, but the bulk of my diet are vegetables (without cereals) and the abundance of that kind of food is reflected in the response of the renal mechanism to maintain the acid-base balance.
Thanks for the weed pulling offer, +Rajini Rao, but our garden is pretty well weed free so it would have to be some deadheading, maybe. Nothing life-threatening in my case--just a long history of work injuries and getting hit in my truck. Ongoing problems with my neck and hands but I can garden, I can play musical instruments, I can all's well. Bending over to pull the odd weed and get a good stretch is one of my favorite things to do in the garden. You see your flowers up close.
+Konstantin Lamanov я смотрю, там кнопка отправил свои 30 зеленых через пайпал.
Немного, но, чем могу...
+Drew Sowersby, you're welcome.
As for the sugar restriction strategy, limiting the concentration of glucose in blood may have in many cases a rather limited effect on the growth of tumor cells. The reason is that many tumor cells express GLUT1 in their membranes in large amounts. GLUT1 is the same glucose transporter as the one expressed in red blood cells and in fetal tissues. In adult cells is also expressed but a very low levels to provide a "basal glucose uptake."

This particular glucose transporter provides an almost constant flux of glucose regardless of the blood glucose concentration in blood since in the physiologic range of glucose concentrations GLUT1 is already saturated. Thus, the rate of glucose influx will mainly depend on the number of transporters expressed in the cell membrane (or the rate conversion of glucose into other molecules).

That said, a lower blood glucose level usually have beneficial physiologic effects for most people, so there's nothing wrong with it unless it's been explicitly advised against (to prevent hypoglycemia in advanced stages of the disease?).

I've made a quick search and the le level of expression of GLUT1 is often rather heterogeneous even in the same tumor. It seems that some tumor-associated cells can perfectly survive without higher expression because they use other substrates like lactate instead. Here you are a brief description of what I mean:

<<Glucose, the main energy source for cancer cells and tumor-associated stroma, reaches the tumor environment through diffusion from the peritumoral and intratumoral vasculature. The expression levels of GLUT1, a key pump for the absorption of glucose by cells, are expected to define the rate of glucose influx into the cells. In the present study, normal colon did not show GLUT1 expression, but this presumably reflects the limits of immunohistochemical technique to detect membranous GLUT1 protein at the baseline concentrations present in the normal tissues or use of other GLUTs. Similarly, the tumor-associated fibroblasts were uniformly negative for GLUT1, suggesting a low level activity. In contrast, cancer cells and tumor-associated vessels exhibited a strong GLUT1 expression. The irregularly, and often poorly, vascularized intratumoral environment indicates that glucose disposition is rather limited and abnormally distributed within tumors. The lack of expression of GLUT1 in tumor-associated fibroblasts probably reflects the specific up-regulation of GLUT1 by various oncogenes. The activation of lactate oxidation by the stromal fibroblasts would use lactate for energy and spare glucose for cancer cells.

In contrast to tumor-associated fibroblasts, the newly formed endothelial cells expressed GLUT1 well above the levels exhibited by mature colon vessels, suggesting active uptake of glucose from the blood stream, ready to be used aerobically for energy production. The oxygen, diffused through the tumor-associated vasculature, seems to be necessary for the survival of intratumoral endothelium and stroma but is unlikely to have a major contribution to energy production for cancer cells, as it is indicated by the low PDH, high PDK1, high LDH5, and high GLUT1 cancer cell reactivity.>>

- Koukourakis MI et al. Comparison of metabolic pathways between cancer cells and stromal cells in colorectal carcinomas: a metabolic survival role for tumor-associated stroma. Cancer Research (2006) vol. 66 (2) pp. 632-7
When I read your comment. +Zephyr López Cervilla I had a moment of discovery. I knew that diet is important in my battle. But I did not know the details. It is sad how some information I do not know of a doctor than to discover over the internet. Thank you. God bless you. Also thx you +Drew Sowersby ... much love for Rajini
what i believe that every one tries to save their family and lover(belongings), wheather it's cancer or anything else till last moment, may be he know that's it's not curable but still tries. i will also going to share , hoping for best.
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