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PolyGene AG
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Custom designed mouse and rat models for biomedical research and human disease
Custom designed mouse and rat models for biomedical research and human disease

3 followers
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Curious about methods in transgenic animal generation?
Join PolyGene for a special seminar on advanced methods at +Inselspital, University Hospital of Bern +Universität Bern .
http://www.polygene.ch/collaborations/events/

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New paper (http://www.sciencedirect.com/science/article/pii/S0896841116303997) about the understanding of automimmunity. In vivo experiments show a clear crosstalk between the classical and alternative NF-κB pathways including the "Relb" locus in medullary thymic epithelial cells. We created a transgenic mouse by inserting a BAC containing the complete Relb locus and theCre-P2A-Katushka fusion Protein using this method:
http://www.polygene.ch/animal-models/overexpression/transgenics/




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We are attending the 44th European Calcified Tissue Society Congress! Meet us there! http://ects2017.org/

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A molecular on/off switch for CRISPR

Picture bacteria and viruses locked in an arms race. For many bacteria, one line of defense against viral infection is a sophisticated RNA-guided "immune system" called CRISPR-Cas. At the center of this system is a surveillance complex that recognizes viral DNA and triggers its destruction. However, viruses can strike back and disable this surveillance complex using "anti-CRISPR" proteins, though no one has figured out exactly how these anti-CRISPRs work—until now. For the first time, researchers have solved the structure of viral anti-CRISPR proteins attached to a bacterial CRISPR surveillance complex, revealing precisely how viruses incapacitate the bacterial defense system. The research team, co-led by biologist Gabriel C. Lander of The Scripps Research Institute (TSRI), discovered that anti-CRISPR proteins work by locking down CRISPR's ability to identify and attack the viral genome. One anti-CRISPR protein even "mimics" DNA to throw the CRISPR-guided detection machine off its trail. "It's amazing what these systems do to one-up each other," said Lander. "It all comes back to this evolutionary arms race."

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What is #CRISPRCas9 and why is it the prefered choice to generate genetically modified mouse models of human disease? Check out our new explanatory graphics! #gem #mousemodel #knockoutmouse #knockinmouse

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Would you like to insert a human gene into the mouse to model diseases like #cancer or #alzheimer?
Check out our knock-in method using #CRISPR/Cas9

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PolyGene is attending the LS2 Meeting at University of Zürich. Come and connect! https://ls2-annual-meeting.ch/

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Collaborate with us on diabetic kidney disease and Alzheimer's! We get your mouse model ready! http://www.polygene.ch/innovative-medicines-initiative-imi2-5th-call-for-proposals/
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