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+Paul Harper I know you've been wanting a serious discussion on one of your posts.

This is an interesting article by John Ioannidis, an MD/statistician who has done extensive work on publication bias and diminishing effects in research.

Systematic Review of the Empirical Evidence of Study Publication Bias and Outcome Reporting Bias
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0003081

It does not paint a rosy picture of science and, frankly, is rather disheartening as someone interested in going into scientific research.
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