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+Paul Harper I know you've been wanting a serious discussion on one of your posts.

This is an interesting article by John Ioannidis, an MD/statistician who has done extensive work on publication bias and diminishing effects in research.

Systematic Review of the Empirical Evidence of Study Publication Bias and Outcome Reporting Bias

It does not paint a rosy picture of science and, frankly, is rather disheartening as someone interested in going into scientific research.
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