The study included 25 centers in the United States, Europe and Israel. Researchers used the StemEx technology for cord blood transplants in 101 leukemia and lymphoma patients. These patients were compared with a historical control group of 295 patients who each received a double dose of cord blood stem cells.
After 100 days, the overall survival was significantly higher in the StemEx group ( 84.2 percent) than in the control group (74.6 percent). The StemEx transplants also were quicker to engraft, i.e., develop into a sufficient number of blood cells. In the StemEx group, engraftment of neutrophil blood cells took a median of 21 days, compared with 28 days in the control group. Engraftment of platelets took a median of 54 days in the StremEx group and 105 days in the control group. (Neutrophils are infection-fighting white blood cells; platelets are small blood components that help the clotting process.) The faster neutrophils and platelets are engrafted, the less time patients are vulnerable to infections and bleeding."
Progress has been made over the years in patient selection, modification of the conditioning regimen, and better choice of the UCB according to cell dose and HLA typing, factors contributing to the improvement of pediatric UCBT results and an increased demand for high-quality UCB units
Ballen K K et al. Blood 2013;122:491-498
©2013 by American Society of Hematology
(A) Children (≤16 years) from Europe: UCBT period 1996-1999 (n = 142), OS: 37 ± 4%; 2000-2005 (n = 441), OS: 41 ± 2%; 2006-2011 (n = 749), OS: 54 ± 2%.
(B) Children (≤16 y) from North America: UCBT period 1996-1999 (n = 276), OS: 45 ± 6%; 2000-2005 (n = 843), OS: 50 ± 3%; 2006-2011 (n = 993), OS: 56 ± 6%.
(C) Adults from Europe: UCBT period 1996-1999 (n = 46), OS: 26 ± 6%; 2000-2005 (n = 339), OS: 37 ± 3%; 2006-2011 (n = 1595), OS: 36 ± 2%.
(D) Adults from North America: UCBT period 1996-1999 (n = 87), OS: 22 ± 8%; 2000-2005 (n = 359), OS: 31 ± 4%; 2006-2011 (n = 1210), OS: 34 ± 3%.
The 5-year disease-free survival rate was 44%. In multivariate analysis, factors predicting better disease-free survival were age younger than 1.4 years at diagnosis (hazard ratio [HR], 0.42; P = .005), 0 to 1 HLA disparities in the donor/recipient pair (HR, 0.4; P = .009), and karyotype other than monosomy 7 (HR, 0.5; P = .02).
The effect of ABO blood group incompatibility on the outcome of single-unit cord blood transplantation following myeloablative conditioning.
- Singapore Cord Blood BankLaboratory Director / Cord Blood Bank Director (NetCord-FACT), 2013 - present
- Singapore Cord Blood BankLaboratory Director, 2012 - present
- Singapore General Hospital, Dept. of HaematologySenior Research Scientist, 2010 - 2012
- Singapore Cord Blood BankQuality Assurance Manager, 2011 - 2012
- Singapore Cord Blood BankDeputy Laboratory Director, 2009 - 2011
I am especially interested in the research and development of cord blood ex vivo expansion. I am also interested in long-term technical development, financial viability and sustainability of public cord blood banking. My goal is to make public cord blood banking a self-sustaining operations, so that it can provide a stable supply of high-quality hematopoietic stem cell resources to all ethnicities and ages for life-saving transplantation treatments at an affordable price.
- University of British Columbia, BC, CanadaPh.D. Medical Genetics and Hematopoietic Stem Cell Biology
- University of Windsor, Windsor, Ontario, CanadaB.Sc. Biological Sciences (Honours)
- W. D. Lowe Secondary School, Windsor, Ontario, Canada
- Yan Chai Hospital Lim Por Yen Secondary School (仁濟醫院林百欣中學), Hong Kong
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