The current way in which we do science is plagued by many fundamental problems.
One of them is that we don't do enough replications. There are many reasons for this. While everyone agrees that it is crucially important for science as a whole to do so, the individuals who would have to do the work have very few incentives (and actually quite a few disincentives) not
to replicate. This is a tragedy of the commons scenario. The question is what to do about it. I think this won't change until the incentive structure changes. +Chris Said
tackled the details of this problem and proposes solutions as to what exactly should be done. This is important stuff. I suggest you have a look.
My only concern is that the notion of "reform" might not go far enough. Re-form implies that there was a previous state that we lost and should aspire to re-attain. Not sure if such a state ever existed. Perhaps it did. But we need to do a lot better than we are, if our field is not going to be built on foundations of clay (not built to last)...