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Owen Phillips
14,766 followers -
Neuroscience
Neuroscience

14,766 followers
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I have a new manuscript out that examines the association between insulin resistance (~diabetes) and smaller brain volumes in children. This work is potentially important as Insulin resistance is reaching epidemic proportions in children worldwide.

https://onlinelibrary.wiley.com/doi/abs/10.1111/pedi.12672

Abstract
Objective
During childhood, the brain can consume up to 65% of total calories and a steady supply of the brain’s main fuel glucose needs to be maintained. Though the brain itself is not dependent on insulin for the uptake of glucose, insulin plays an important role in energy homeostasis. Thus, risk for insulin resistance during brain development may negatively impact whole brain volume.

Methods
We investigated the link between insulin resistance and whole brain volume as measured by structural MRI in 46 unmedicated depressed and overweight youth between the ages of 9 to 17 years.

Results
Smaller whole brain volumes were associated with insulin resistance independent of age, sex, depression severity, body mass index, socioeconomic status, Tanner Stage, and IQ (r=0.427, p=0.008).

Conclusions
There may be a significant cost of insulin resistance on the developing brain. Disentangling the precise relation between insulin resistance and the developing brain is critical.
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New Anti-NMDAR research!
http://jnnp.bmj.com/content/early/2017/11/03/jnnp-2017-316822
"Superficial white matter damage in anti-NMDA receptor encephalitis"

The picture is one I made that shows the superficial white matter.
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Snapshots in Alsace and Strasbourg
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Snapshots in Tübingen
Snapshots in Tübingen
Snapshots in Tübingen
blog.owenphillips.com
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Snapshots in the Bay Area
Snapshots in the Bay Area
Snapshots in the Bay Area
blog.owenphillips.com
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Snapshots in Amsterdam, Geneva, and Zurich
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Snapshots in the Bay Area
Snapshots in the Bay Area
Snapshots in the Bay Area
blog.owenphillips.com
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New Publication Out: Major Superficial White Matter Abnormalities in Huntington's Disease
I have a new publication out, please take a look. Major Superficial White Matter Abnormalities in Huntington's Disease http://journal.frontiersin.org/article/10.3389/fnins.2016.00197/full Abstract: Background:  The late myelinating superficial white matter ...
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Please take a look!!!!! -Manuscript at: goo.gl/T16GD8
I have a new paper out! This is work I did with a great people in Italy and UCLA's +Shantanu Joshi and +David Shattuck!
Major Superficial White Matter Abnormalities in Huntington's Disease
http://journal.frontiersin.org/article/10.3389/fnins.2016.00197/full
This paper is open access which was one of the reasons we went with Frontiers.
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