We humans will do it to ourselves.
Once we get a pretty good grasp of DNA/RNA manipulation we will them engineer and edit human bodies and minds into much better forms. Able to erase genetic (and likely viral/bacterial) disease. Move on to creating what we would call today as "Super Bodies". Rapidly pushing forward the advanced possibilities through engineered genetics and biology.
Once we get a pretty good grasp of the operations of the brain, and found the best way to transcribe its functionality into other substrates such as electronics/quantum systems/photonics/etc... we will them find ways to enhance human minds via technology both external and internal to the body. Backing up minds for protection versus death. Designing non-biological bodies which can be used by our minds. Changing our forms and mentality much in the same way as we change clothes today.
and yes... I think once we have learned how this can be done, and done safely and repeatedly, then we shall quite voluntarily end what it literally means to be human in the sense we know it literally as today for something that is post human... super human... and beyond what we could ever anticipate or describe today.
Sorry if I am waxing optimistic, and largely in a bent towards the Ray Kurzweil type of future. Yet it is easy to say and most would agree that are swiftly moving into very profound and amazing times. Whether this can be viewed as good or bad is subjective, and everyone will interpret it a bit differently I imagine. Yet I can't help but think we are moving in that direction. (barring incredible events which erase mankinds grasp on knowledge and technology...)
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