Toxtree helping safe by design
E. Canellas, P. Vera, and C. Nerín, “Migration assessment and the ‘Threshold of Toxicological Concern’ applied to the safe-design of an acrylic adhesive for food contact laminates,” Food Addit. Contam. Part A, p. 19440049.2017.1308017, Mar. 2017. http://www.tandfonline.com/doi/abs/10.1080/19440049.2017.1308017
"The software Toxtree (IdeaconsultLtd 2011) was used for the Cramer class
assignation. This software assigned the Cramer classes according the decision tree developed with the Cramer rules (Cramer, Ford and Hall 1978). These compounds were classified in Cramer class II and III (legend of figure 3) with a self-derived SMLs of 0.54 mg/kg and 0.09 mg/kg respectively. As it can be seen in figure 3, the migration values obtained for the surfactant polymer were higher than the self-derived SML. As a result, it was decided to remove this surfactant from the formulation. This fact, highlights the importance of the safe-design adhesive strategy followed since if the migration through the different materials in the laminates had not be studied, the surfactant would not have been replaced."
E. Canellas, P. Vera, and C. Nerín, “Migration assessment and the ‘Threshold of Toxicological Concern’ applied to the safe-design of an acrylic adhesive for food contact laminates,” Food Addit. Contam. Part A, p. 19440049.2017.1308017, Mar. 2017. http://www.tandfonline.com/doi/abs/10.1080/19440049.2017.1308017
"The software Toxtree (IdeaconsultLtd 2011) was used for the Cramer class
assignation. This software assigned the Cramer classes according the decision tree developed with the Cramer rules (Cramer, Ford and Hall 1978). These compounds were classified in Cramer class II and III (legend of figure 3) with a self-derived SMLs of 0.54 mg/kg and 0.09 mg/kg respectively. As it can be seen in figure 3, the migration values obtained for the surfactant polymer were higher than the self-derived SML. As a result, it was decided to remove this surfactant from the formulation. This fact, highlights the importance of the safe-design adhesive strategy followed since if the migration through the different materials in the laminates had not be studied, the surfactant would not have been replaced."
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