Dementia Gene May Guard Against Decline Associated With Parasitic Disease

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Trumble and colleagues examined cognitive performance and parasite exposure data from a remote population of forager-horticulturalists in the Bolivian Amazon, called the Tsimane. The Tsimane experience high parasite loads, making them a suitable population for study for the role of the E4 allele in this circumstance. The researchers undertook a genetic analysis, measured immune markers of parasitic infection, and conducted cognitive tests on 372 Tsimane men and women aged 6 to 88 years.

The research is in The FASEB Journal. (full access paywall)
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