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New Link Between Alzheimer's and Diabetes Discovered

Researchers have uncovered a unique connection between diabetes and Alzheimer's disease, providing further evidence that a disease that robs people of their memories may be affected by elevated blood sugar, according to scientists at Washington University School of Medicine in St. Louis.

The research is in Journal of Clinical Investigation. (full open access)

#alzheimersdisease   #neurology   #diabetes  
Researchers report they have uncovered a unique connection between diabetes and Alzheimer's disease.
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+Dee Deason Except it is essential for all living things, and you brain pretty much only uses glucose.
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Epigenetic Drugs Could be Used to Treat Deadly Pediatric Cancer

Full article at http://neurosciencenews.com/dipg-brain-cancer-epigenetic-medication-2026/.

Using brain tumor samples collected from children in the United States and Europe, an international team of scientists found that the drug panobinostat and similar gene regulating drugs may be effective at treating diffuse intrinsic pontine gliomas (DIPG), an aggressive and lethal form of pediatric cancer.

The research is in Nature Medicine. (full access paywall)

Research: "Functionally defined therapeutic targets in diffuse intrinsic pontine glioma" by Catherine S Grasso, Yujie Tang, Nathalene Truffaux, Noah E Berlow, Lining Liu, Marie-Anne Debily, Michael J Quist, Lara E Davis, Elaine C Huang, Pamelyn J Woo, Anitha Ponnuswami, Spenser Chen, Tessa B Johung, Wenchao Sun, Mari Kogiso, Yuchen Du, Lin Qi, Yulun Huang, Marianne Hütt-Cabezas, Katherine E Warren, Ludivine Le Dret, Paul S Meltzer, Hua Mao, Martha Quezado, Dannis G van Vuurden, Jinu Abraham, Maryam Fouladi, Matthew N Svalina, Nicholas Wang, Cynthia Hawkins, Javad Nazarian, Marta M Alonso, Eric H Raabe, Esther Hulleman, Paul T Spellman, Xiao-Nan Li, Charles Keller, Ranadip Pal, Jacques Grill and Michelle Monje in Nature Medicine doi:10.1038/nm.3855

Image: Scientists found that the drug panobinostat may be effective at treating diffuse intrinsic pontine gliomas, the leading cause of pediatric brain cancer death. Image credit Monje lab, Stanford University, CA.

#cancer   #neurology  
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That is amazing!
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Three Previously Unrelated Theories About Cause of Schizophrenia Linked

Full article at http://neurosciencenews.com/schizophrenia-genetics-dopamine-2022/.

Mouse model will help scientists parse brain-based findings.

The research is in Nature Neuroscience. (full access paywall)

Research: "Spine pruning drives antipsychotic-sensitive locomotion via circuit control of striatal dopamine" by Il Hwan Kim, Mark A. Rossi, Dipendra K. Aryal, Bence Racz, Namsoo Kim, Akiyoshi Uezu, Fan Wang, William C. Wetsel, Richard J. Weinberg, Henry Yin, and Scott H. Soderling in Nature Neuroscience. Published online May 4 2015 doi:10.1038/nn.4015

Image: Overactive neurons in the front of the mouse brain, shown in green, trigger excessive release of the brain chemical dopamine, which causes motor abnormalities. Image credit: Soderling lab, Duke University.

#schizophrenia   #neuroscience  
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neat
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Could Green Tea Extract and Exercise Hinder Alzheimer's Progression?

Comprehensive study of EGCG, a compound found in green tea, could lead to treatments of Alzheimer’s in humans.

The research is in Journal of Alzheimer's Disease. (full access paywall)

#neurology   #alzheimersdisease  
A new study reports green tea extract and exercise appears to slow the progression of Alzheimer's disease in mice.
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Reward Response Increased by Oxytocin in Women Viewing Crying Babies

Full article at http://neurosciencenews.com/oxytocin-reward-crying-baby-vta-2021/.

The hormone didn't have the same effect on women viewing images of smiling infants.

The research is in Hormones and Behavior. (full access paywall)

Research: "Oxytocin increases VTA activation to infant and sexual stimuli in nulliparous and postpartum women" by Rebecca Gregory, Hu Cheng, Heather A. Rupp, Dale R. Sengelaub, and Julia R. Heiman in Hormones and Behavior doi:10.1016/j.yhbeh.2014.12.009

Image: Oxytocin, especially given its connection to significant reproductive events for women, might facilitate the appeal and motivation to help an upset baby since responding to infant distress is so critical in the early months of life. The image is for illustrative purposes only. Image credit TaniaVdB.

#psychology   #oxytocin  
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Look at his eyes
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Chemogenetic Technique Turns Mouse Behavior On and Off

Neuroscientists have perfected a chemical-genetic remote control for brain circuitry and behavior.  This evolving technology can now sequentially switch the same neurons – and the behaviors they mediate – on-and-off in mice, say researchers funded by the National Institutes of Health. Such bidirectional control is pivotal for decoding the brain workings of complex behaviors. The findings are the first to be published from the first wave of NIH grants awarded last fall under the BRAIN Initiative.

The research is in Neuron. (full access paywall)

#chemogenetics   #neuroscience  
A new, non-invasive technique helps researchers to modulate neurons.
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Fuzzy Thinking Rooted in Brain Activity Differences

Full article at http://neurosciencenews.com/neural-activity-fuzzy-thinking-2027/.

Very large U-M study adds to evidence that mood disorders are points on a spectrum, not completely separate -- and could lead to better diagnostic tests.

The research is in Brain. (full access paywall)

Research: "Shared dimensions of performance and activation dysfunction in cognitive control in females with mood disorders" by Kelly A. Ryan, Erica L. Dawson, Michelle T. Kassel, Anne L. Weldon, David F. Marshall, Kortni K. Meyers, Laura B. Gabriel, Aaron C. Vederman, Sara L. Weisenbach, Melvin G. McInnis, Jon-Kar Zubieta, and Scott A. Langenecker in Brain doi:10.1093/brain/awv070

Image: These regions of the brain were most associated with poor performance on the "fast thinking" test, both among women with depression and women with bipolar disorder. Image credited to the researchers.

#psychology   #depression  
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i could see my brain all over the place LOL
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Epigenetic Drugs Could be Used to Treat Deadly Pediatric Cancer

Full article at http://neurosciencenews.com/dipg-brain-cancer-epigenetic-medication-2026/.

Using brain tumor samples collected from children in the United States and Europe, an international team of scientists found that the drug panobinostat and similar gene regulating drugs may be effective at treating diffuse intrinsic pontine gliomas (DIPG), an aggressive and lethal form of pediatric cancer.

The research is in Nature Medicine. (full access paywall)

Research: "Functionally defined therapeutic targets in diffuse intrinsic pontine glioma" by Catherine S Grasso, Yujie Tang, Nathalene Truffaux, Noah E Berlow, Lining Liu, Marie-Anne Debily, Michael J Quist, Lara E Davis, Elaine C Huang, Pamelyn J Woo, Anitha Ponnuswami, Spenser Chen, Tessa B Johung, Wenchao Sun, Mari Kogiso, Yuchen Du, Lin Qi, Yulun Huang, Marianne Hütt-Cabezas, Katherine E Warren, Ludivine Le Dret, Paul S Meltzer, Hua Mao, Martha Quezado, Dannis G van Vuurden, Jinu Abraham, Maryam Fouladi, Matthew N Svalina, Nicholas Wang, Cynthia Hawkins, Javad Nazarian, Marta M Alonso, Eric H Raabe, Esther Hulleman, Paul T Spellman, Xiao-Nan Li, Charles Keller, Ranadip Pal, Jacques Grill and Michelle Monje in Nature Medicine doi:10.1038/nm.3855

Image: Scientists found that the drug panobinostat may be effective at treating diffuse intrinsic pontine gliomas, the leading cause of pediatric brain cancer death. Image credit Monje lab, Stanford University, CA.

#braincancer   #neurology   #cancer  
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Love the good news 
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Premature Birth Can Alter Neural Connectivity

Full article at http://neurosciencenews.com/brain-connectivity-preterm-birth-2024/.

Premature birth can alter the connectivity between key areas of the brain, according to a new study led by King’s College London. The findings should help researchers to better understand why premature birth is linked to a greater risk of neurodevelopmental problems, including autistic spectrum disorders and attention deficit disorders.

The research is in PNAS. (full open access)

Research: "Specialization and integration of functional thalamocortical connectivity in the human infant" by Hilary Toulmin, Christian F. Beckmann, Jonathan O'Muircheartaigh, Gareth Ball, Pumza Nongena, Antonios Makropoulos, Ashraf Ederies, Serena J. Counsell, Nigel Kennea, Tomoki Arichi, Nora Tusor, Mary A. Rutherford, Denis Azzopardi, Nuria Gonzalez-Cinca, Joseph V. Hajnal, and A. David Edwards in PNAS. Published online May 4 2015 doi:10.1073/pnas.1422638112

Image: The greater the extent of prematurity, the more marked were the differences in the pattern of brain connectivity. Image adapted from the KCL press release.

#neurology   #neurodevelopment  
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That is amazing i think 
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Long Term Cosmic Ray Exposure Causes Lasting Cognitive Impairment in Astronauts

Full article at http://neurosciencenews.com/astronaut-cosmic-ray-cognition-2022/.

Findings of UCI study have implications for astronauts on extended spaceflights.

The research is in Science Advances. (full open access)

Research: "What happens to your brain on the way to Mars" by Vipan K. Parihar, Barrett Allen, Katherine K. Tran, Trisha G. Macaraeg, Esther M. Chu, Stephanie F. Kwok, Nicole N. Chmielewski, Brianna M. Craver, Janet E. Baulch, Munjal M. Acharya, Francis A. Cucinotta, and Charles L. Limoli in Science Advances doi:10.1126/sciadv.1400256

Image: People working for extended periods on the International Space Station do not face the same level of bombardment with galactic cosmic rays, as they are still within the protective magnetosphere of the Earth. The image is for illustrative purposes only. Image credit: WikiImages.

#neuroscience   #dementia   #space  
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That's known by decades but coatings are being developed.
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Monitoring Neural Stem Cells After Transplantation

The ability to detect successful engraftment, integration and function of human cells implanted into the brain of a living animal could potentially speed stem-cell therapies’ path to clinical use.

The research is in NeuroImage. (full access paywall)

#genetics   #neuroscience   #stemcells  
A new study reports researchers have created a new way to monitor neural stem cells after they have been transplanted into the brain.
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Research Aims to Accelerate Memory Function for Skill Learning

Full article at http://neurosciencenews.com/ram-recall-memory-2019/.

Research may accelerate rehabilitation post trauma or memory impairment, enable warfighter training.

Image: Human memory is the result of biological processes that culminate in the formation or strengthening of neural connections in the brain. Image credit: DARPA.

#neuroscience   #memory   #learning  
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that most be design only for cloud
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