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Micar Innovation Micar21
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Micar Innovation (Micar21.com)- provide Drug Discovery FASTER - using in silico and Artificial Intelligence
Micar Innovation (Micar21.com)- provide Drug Discovery FASTER - using in silico and Artificial Intelligence

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Our new paper "An Improved Free Energy Perturbation FEP+ Sampling Protocol for Flexible Ligand-Binding Domains" has been uploaded to ChemXriv and submitted for a review. We hope that our new FEP+ sampling protocol will be adopted by many researchers because it improves the binding affinity predictions by 40-50% and will be useful during the lead optimization drug discovery process.


https://chemrxiv.org/articles/An_Improved_Free_Energy_Perturbation_FEP_Sampling_Protocol_for_Flexible_Ligand-Binding_Domains/6204167
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Our common paper with Schrodinger company "Prediction of Accurate Binding Modes using Combination of classical and accelerated Molecular dynamics and Free Energy Perturbation Calculations: An Application to Toxicity Studies" has been submitted. This the first part of our more global study on the improvements of several state of art in silico approaches with an application in drug discovery process, which also describes our technology. Papers about the improvement of the FEP+ sampling protocol and a novel hit identification protocol, tested during the discovery of new GLY2 and AKT1 inhibitors, are underway. More information about these approaches can be found now on a ResearchGate:

1) An Improvement of the Free Energy Perturbation (FEP+) Sampling Protocol in Case of Flexible protein Ligand Binding Sites

2) Combination of Structural based Pharmacophore and Docking Virtual Screens: An Efficient Structure-based Protocol for Lead Identification

https://www.researchgate.net/publication/321151151_An_Improvement_of_the_Free_Energy_Perturbation_FEP_Sampling_Protocol_in_Case_of_Flexible_protein_Ligand_Binding_Sites

https://www.researchgate.net/publication/322632892_Combination_of_Structural_based_Pharmacophore_and_Docking_Virtual_Screens_An_Efficient_Structure-based_Protocol_for_Lead_Identification

http://micar21.com/Prediction-of-Accurate-Binding-Modes-using-Combination-of-classical-and-accelerated-Molecular-dynamics-and-Free-Energy-Perturbation-Calculations-An-Application-to-Toxicity-Studies

https://www.biorxiv.org/content/early/2018/01/24/251058
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Micar Innovation (Micar21) named Best Biotech Startup of the year 2017 in CEE - Bulgaria National Winners

On the 4th edition of the Central European Startup Awards finals, competition that includes national finalists from 10 countries in Central and Eastern Europe, Micar Innovation (Micar21) was named Best Biotech Startup of the year in CEE - Bulgaria National Winners.

The Central European Startup Awards launched in 2014 and covers currently 10 countries (Austria, Bulgaria, Croatia, Czech Republic, Hungary, Poland, Romania, Serbia, Slovakia and Slovenia). The initiative has become the region’s largest startup festival, spotlighting the best entrepreneurs and investors across the region. The CESA have been steadily growing in popularity, with last year’s event receiving over 800 nominations. More about us you can find here:
http://micar21.com
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31.01.18 г.
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From over 930 startups have already applied Micar Innovation Ltd. has been selected by Webit.Foundation, along with other 70 companies, to have a chance to pitch and win € 200'000!
http://www.webit.bg/agenda.php#startup
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PPARγ receptor activation helix (helix 12 (H12)) can exist in an antagonist form
 
PPARγ antagonist –like conformation of activation helix - helix 12 obtained by 1μs aMD simulation. Note the exchange of an agonist to antagonist conformation at about the 30th second.
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 A new paper has been published by the Micar21 team, which reveal, for the first time, how the famous PPARγ receptor looks in its antagonist form. This is an initial study of the PPARγ antagonist structure and a second, and more detail paper, is on the way to be published. ....

http://micar21.com/Structural-and-Dynamical-Insight-into-PPAR%CE%B3-Antagonism-In-silico-Study-of-the-Ligand-Receptor-Interactions-of-non-Covalent-Antagonists
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 Създайте единствен по рода си патентован козметичен продукт за световния пазар. Направете вашата козметична линия конкурентоспособна в целия свят! 

Micar21 ви дава тази възможност!

http://bg.medicinalcosmeticsdevelopment.com/
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Our paper titled "Activation helix orientation of estrogen receptor is mediated by receptor dimerization: evidence from molecular dynamics simulations" was published in the Physical Chemistry Chemical Physics journal (IP=4.2).
http://pubs.rsc.org/en/content/articlelanding/2015/cp/c5cp00327j/Unauth#!divAbstract
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