Are methadone and prednisone safe to take together? #DrugInteractions Community Discussion: “Hi Theresa, not sure if you were able to ask your doc yet about the possibility of your prednisone dose minimizing the efficacy of your daily methadone dose. I've been on suboxone for several years & due to some very infrequent dermatitis flare-ups on my hands, my subox doc has prescribed me oral prednisone 2 different times. It's been a few years now but I do recall taking it in that special way you described, where you start off with more & end up with less & I think I took it in an increment of 1 week. I had no side effects at all & my suboxone was as effective as it has always been. I do recall my doctor stressing with me something I was somewhat already familiar with due to having a good friend who took prednisone for quite a while, and that was to take it for as short a time as possible....One of those quirky meds that is so helpful for so many uncomfortable conditions yet if taken too long of a period produces some unpleasant side effects, weight gain & "Moon" face....Good luck to you!“
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