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McMaster Institute for Infectious Disease Research
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World-leading Centre for Infectious Disease Research
World-leading Centre for Infectious Disease Research

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Dr. Jianping Xu's research team at the Michael G. DeGroote Institute for Infectious Disease Research discovers significant and broadly distributed drug-resistant strains of Aspergillus fungi in Hamilton, Canada.

Read the press release at https://bit.ly/2QJqaGO.
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In a recent review in Disease Models & Mechanisms, Postdoctoral Fellow Dr. Jocelyn Wessels of Dr. Charu Kaushic’s lab takes an extensive look at the current literature regarding various HIV-1 susceptibility determinants to propose viable correlations between the sex-hormone–microbiome–immunity axis and HIV-1 acquisition in women.

https://bit.ly/2D68d2t
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One way in which Gram-positive bacteria compete with neighbouring bacteria is by secreting antibacterial toxins through a protein complex known as the bacterial type VII secretion system (T7SS). Master's student Tim Klein of Dr. John Whitney's lab investigates the mechanisms by which Streptococcus immune proteins protect cells from antibacterial toxins. https://bit.ly/2xcZnK2
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Are you a man over 40 years old? Would you like to take part in a research study at McMaster? Dr. Bowdish's lab is studying how age-related changes in immune responses alter the microbes that live in our nose and mouth. Find out more at https://bit.ly/2N5FBem!
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PhD students Shehryar Ahmad from the McMaster Institute for Infectious Disease Research (IIDR) and Dennis Quentin from the Max Planck Institute for Molecular Physiology leverage their combined expertise in biochemistry, genetics, and structural biology to investigate the critical first steps of toxin delivery by the T6SS. Read more at https://bit.ly/2x2AmC2.
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The IIDR is inviting applications for it's newest award, the Gerard Wright Postdoctoral Award in Infection Research.

This award will be presented to an IIDR Postdoctoral or MD Fellow whose research has made a significant contribution to the field of infection research over the past year.

Find out how to apply at https://bit.ly/2N75dGR.
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A small, black box developed by Dr. Shawn French of Dr. Eric Brown's lab at the McMaster Institute for Infectious Disease Research could change the way scientists search for new antibiotics.

https://bit.ly/2NvsPC5
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Biofilms are thin, slimy films of bacteria that adhere to surfaces and are difficult to eradicate.

They provide bacteria with increased protection from antibiotics and host defences, and recent studies have shown that exposing bacteria to subinhibitory concentrations of antimicrobials can provoke physiological changes that lead to increased biofilm production and potential therapeutic failure.

In a recent issue of Current Opinion in Microbiology, Burrows’ lab MSc student Michael Ranieri describes the current hypotheses regarding the mechanisms underlying biofilm stimulation in response to subinhibitory antimicrobials, and propose ways in which one might inhibit this response to potentiate antibiotic action.

Read more at https://bit.ly/2MxZwlX.
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Approximately 2 million new HIV-1 infections arise each year and disproportionately affect young women. Yet, the mechanisms that regulate HIV-1 susceptibility within the female genital tract are poorly understood.

Dr. Charu Kaushic’s research team describes our current understanding of the acute events that occur in the female genital tract following HIV-1 exposure, and goes further to discuss the potential influence of sex hormones on HIV-1 susceptibility in the female genital tract.

Read more at https://onlinelibrary.wiley.com/doi/full/10.1111/aji.13019.
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Coombes' lab PDF Dr. Dustin Little characterizes the structural details behind essential interactions that allow enteropathogenic E. coli to infect their hosts. Visit: https://bit.ly/2wjh2zY
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