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Matthew Todd
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Matthew Todd
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Paper  - 
 
Github repository set up for the writing of the first OSM paper on Series 4. Should allow anyone to contribute directly on that platform, or (more old school) download files, alter them and then ask for them to be uploaded by emailing them to opensourcemalaria@gmail.com. Either way this ought to make the assembly of the paper in a submission-ready form easier, as well as adding robust version control.
OSMSeries4Paper1 - Working Repository of Files Related to Open Source Malaria Series 4, Paper 1
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Call for help in synthesising the next most-wanted compounds in OSM Series 4. After much consideration, these are the ones needed. A few milligrams of each are required for biological evaluation. As usual, contribution of samples, and the associated data, makes the contributor eligible for possible inclusion as an author on the resulting paper. The compounds have a lot of synthetic organic precedence behind them and are available in 4 steps from a commercial starting material. #malaria #openscience  
The 'top ten' Series Four compounds have been defined as: I (Alice) will firstly take care of compounds 1 - 4 at Sydney University meaning that we'd like to open up compounds 5 - 10 for synthesis by the community. Two proposed synthetic routes for 5 - 10 could be accessed are: ...
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Matthew Todd
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Discussion  - 
 
WashPo article on the innovation value/power, or not, of patents
Technology moves so quickly today that patents only hold back our best minds.
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Matthew Todd
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New Papers  - 
 
Article in NRDD from 2014 claiming pharma R&D is on the comeback trail
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Matthew Todd
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New Papers  - 
 
Big collection of papers on NTD drug discovery in Chem Rev: http://pubs.acs.org/doi/abs/10.1021/cr500546h
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Matthew Todd
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Recent Research  - 
 
Background on inhibition of ATP4, the proposed target of OSM's Series 4. There is a strikingly broad array of chemotypes that inhibit this target. If we're going to understand this we need to build a pharmacophore model for the Series. This project will start soon, once we've gathered all the data, but this post contains the background. #malaria #medchem #drugdiscovery  
There is evidence from Kiaran Kirk's lab that Series 4 of the OSM Consortium inhibits ATP4, an ion homeostasis pump that has become an important target in antimalarial drug discovery. This importance stems from it being an apparently validated target with a candidate, KAE609, in the clinical ...
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New open source drug candidate series to explore, originating from GSK. We're looking at it, and anyone else is free to jump in. Promising initial data. Now seeking analogs. #tuberculosis  
In recognition of it being World TB day today, and to promote the development of urgently needed new medicines for this terrible disease I'd like to point people to a project they can be involved i...
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Sources of Money  - 
 
Article on delinkage in antibiotic drug R&D
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In his circles
181 people
Have him in circles
788 people
Buy Assignment's profile photo
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Alice Leung's profile photo
Soo Jean Park's profile photo
Leon Wessels's profile photo
Elmo Ranelli's profile photo
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Sydney - London - San Francisco - Manchester - Berkeley
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University of Sydney
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I research and teach organic chemistry at The University of Sydney. Open Science, Neglected Tropical Diseases, Asymmetric Catalysis, Synthetic Organic Chemistry, Coordination Chemistry.
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Difficult to find somewhere that does proper shoe repairs and re-soling. These guys did a very good job. Stitching, good leather repairs, the lot. Also gave honest advice about when to retire a pair of shoes.
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