Just lost my first serious fortress - 100 dwarfs at its peak.
Minotaur, followed immediately by a goblin siege with a concurrent undead wasp, another minotaur and cave crawlers. That was followed by a second goblin siege with heavier guys, but I think it was a moot point by then since nearly everyone was going insane by that time.
It was sad. I was even sad to see my mayor (whom I'm pretty sure was a vampire) run around as the final victim.
On the other hand, I'm glad everyone got killed because I did not want to clean up that mess.