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Matthew Collins
Works at University of York
Attended University of Wales, Bangor
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Matthew Collins
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Postdoctoral Position funded by ERC Consolidator Grant in La Laguna, Tenerife, Spain

Application Open Until Filled. Interviews to be held at IMOG-Prague. 

ERC Consolidator Grant project PALEOCHAR is offering a 3-year postdoc position at Universidad de La Laguna, Tenerife (Spain) for an experienced organic geochemist to carry out biomarker research on sediment from Neanderthal fireplaces. The project will involve a combination of organic geochemical techniques including GC-MS, GC-IRMS and PY-GCMS. This opportunity will remain open until the position is filled.

For more information and to apply, please contact Carolina Mallol at cmallol@ull.es.
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Online Ancient Genome Repository (OAGR) is an open access repository for ancient human DNA data.

It captures and catalogues ancient human genome and microbiome data, including raw sequence and processed data, along with metadata about its provenance and production. Included datasets are generated from ancient samples studied at the Australian Centre for Ancient DNA, University of Adelaide in collaboration with other research groups.

Datasets and collections in OAGR are open data resources made freely available in a reusable form, using open file formats and licensed with minimal restrictions for reuse. Digital object identifiers (DOIs) are minted for included datasets and collections to facilitate persistent identification and citation.
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A small set of exclusive pictures show the world famous Denisova Cave in the Altai Mountains from which a series of stunning scientific discoveries on man's origins have been made in recent years.
New revelations expected as Novosibirsk experts share latest ancient finds with world's leading specialists.
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Two different studies published this week show that the first Americans may have migrated from different places at different times — and earlier than people thought. Read more from NPR: http://23me.co/sTXDMj
Scientists assume a wave of people from what's now Siberia crossed into North America via Alaska, maybe 23,000 years ago. Genetics support that, but may also suggest another wave from Australasia.
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Matthew Collins
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Ancient DNA (a-DNA) studies in past three decades has been uplifted from short stretch archaeological mtDNA retrieval to reconstruction of complete mitochondrial genome sequence using next generation sequencing. Study of a-DNA acts as validating tool to test the assumed hypothesis used in origin, evolution, diversification, distribution, domestication and extinction of species; although, scientific progression in the field is frequently hindered by erroneous reports due to contamination and other technical bottlenecks. With the advent of appropriate methodologies such as 3’-C3 spacer tagged oligonucleotide blocking, shotgun sequencing, amplicon sequencing Polymerase Chain Reaction, single primer extension methodology, development of broad spectrum ancient sequence primer, slippage proof amplification methods, use of multiplexing strategy in PCR (Polymerase Chain Reaction) amplification, etc. in a-DNA research try to minimize the difficulties associated with it. Present review highlighted the pitfalls as well as prospects of a-DNA study and tries to assess the significance and acceptability of a-DNA research for its future application in understanding of evolutionary biology.
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Postdoctoral Research Assistant in the Effects of the Industrial Revolution on Oral Biology and Health

The School of Archaeology, 34-36 Beaumont Street, Oxford
Grade 7: £30,434 - £37,392 p.a.
Applications are invited for a postdoctoral research assistant position to work on a project entitled: 'Investigating the effects of the Industrial Revolution on oral biology and health' funded by the Oxford University Fell Fund. The successful candidate will join a multi-disciplinary team of archaeologists and geneticists to explore how applying a variety of analyses to ancient human dental calculus can enable a quantitative investigation of a broad suite of bacterial, dietary, and environmental factors that contribute to human health and disease. The project is led by Dr Greger Larson at Oxford in collaboration with Drs Tina Warriner and Camilla Speller at Oklahoma and York Universities, respectively.

https://www.recruit.ox.ac.uk/pls/hrisliverecruit/erq_jobspec_version_4.display_form
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Woolly mammoths and the living elephants are characterized by major phenotypic differences that allowed them to live in very different environments. To identify the genetic changes that underlie the suite of adaptations in woolly mammoths to life in extreme cold, we sequenced the nuclear genome from three Asian elephants and two woolly mammoths, identified and functionally annotated genetic changes unique to the woolly mammoth lineage. We find that genes with mammoth specific amino acid changes are enriched in functions related to circadian biology, skin and hair development and physiology, lipid metabolism, adipose development and physiology, and temperature sensation. Finally we resurrect and functionally test the mammoth and ancestral elephant TRPV3 gene, which encodes a temperature sensitive transient receptor potential (thermoTRP) channel involved in thermal sensation and hair growth, and show that a single mammoth-specific amino acid substitution in an otherwise highly conserved region of the TRPV3 channel strongly affected its temperature sensitivity. Our results have identified a set of genetic changes that likely played important roles in the adaptation of woolly mammoths to life in the high artic.
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Postdoctoral fellowship in of ancient DNA analysis

The Graduate School “Human Development in Landscapes” at Kiel University, Germany (www.gshdl.de), which has been established as part of the DFG-Excellence Initiative, invites applications for a full-time  postdoctoral position. We are seeking an energetic and highly motivated postdoctoral fellow to conduct world-class research in the field of ancient DNA analysis. The contract runs for two years or until October 31, 2017 (whatever occurs first), and starts as soon as possible. The salary will be at the level of TV-L 13. The position is assigned to the Medical Faculty. Prerequisite is a Ph.D. in a discipline relevant for the project. An interest in archaeological questions is welcomed. Preference will be given to individuals with a solid publication record. The applicant is expected to address research questions in Evolutionary Medicine, Anthropology/ Archaeology with a focus on the genetic and genomic analysis of ancient DNA. Special emphasis will be placed on the establishment of a state-of-the-art ancient DNA laboratory, the development of enrichment and Next Generation Sequencing technologies (NGS) and the bioinformatic analysis of ancient NGS data. A good working knowledge of German is required.  The applicant is expected to participate in the supervision of PhD students and in teaching. The candidate will be involved in the development of the doctoral program of the Graduate School that provides an international and stimulating atmosphere for research into the interaction of humans and their environment.  Kiel University is an equal opportunity employer and aims to increase the number of women in research and teaching. Applications by women are particularly welcome, and, in cases of equal aptitude, ability and professional performance, preference in hiring will be given to women. The University supports the employment of disabled persons. Persons with disabilities will, with appropriate qualifications and aptitudes, be employed preferentially. Applications by people with a migration background are particularly welcomed. Please refrain from submitting application photos. To apply, submit a covering letter, a detailed CV, two letters of recommendation, certificates of degrees and copies of up to three selected relevant publications. Applications (as hardcopy and as one single PDF) should be sent until September 1, 2015 to Prof. Dr Johannes Müller  GSHDL / Johanna Mestorf Academy at Kiel University Leibnizstr. 3 D-24118 Kiel application@gshdl.uni-kiel.de 
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Powered by next-generation sequencing technologies, ancient DNA enters its golden age
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Genetic evidence for two founding populations of the Americas
Pontus Skoglund, et al 

Nature (2015) doi:10.1038/nature14895

Genetic studies have consistently indicated a single common origin of Native American groups from Central and South America1, 2, 3, 4. However, some morphological studies have suggested a more complex picture, whereby the northeast Asian affinities of present-day Native Americans contrast with a distinctive morphology seen in some of the earliest American skeletons, which share traits with present-day Australasians (indigenous groups in Australia, Melanesia, and island Southeast Asia)5, 6, 7, 8. Here we analyse genome-wide data to show that some Amazonian Native Americans descend partly from a Native American founding population that carried ancestry more closely related to indigenous Australians, New Guineans and Andaman Islanders than to any present-day Eurasians or Native Americans. This signature is not present to the same extent, or at all, in present-day Northern and Central Americans or in a ~12,600-year-old Clovis-associated genome, suggesting a more diverse set of founding populations of the Americas than previously accepted.
A number of natives of the Amazon rainforest may partly descend from the Pacific, though researchers don't know when and how this group called Population Y made its way to the Amazon.
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Wow, now I read the criticism in the original paper. Thanks +Matthew Collins  for share this hot news. 
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As the field of ancient DNA (aDNA) enters its third decade, it is perhaps time to reflect on the amazing transformation that it has undergone. During the first two decades, analyses of aDNA were mainly focussed on mitochondrial and/or chloroplast DNA as a result of their multicopy abundance in the cell, making retrieval and reproducibility much easier. Study of mitochondrial DNA through time allows evolutionary relationships between species to be resolved, molecular clocks to be calibrated, the geographical origins of samples to be revealed, and the investigation of demographic histories. However, not until the advent of massive parallel sequencing [also know as second-generation sequencing and next-generation sequencing (NGS)] was possible to retrieve and study nuclear DNA on a more routine base. Ancient nuclear DNA can additionally be used to identify extinct phenotypes, assess the degree of admixture, and examine selection pressures. This is a short review of what has been, what may come, and how aDNA has influenced NGS. Although examples from archaeology are used to illustrate the impact of NGS technologies on the field, this approach has also been successfully applied to a range of disciplines, such as medicine and wildlife forensics.
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Work
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BioArCh Department of Archaeology
Employment
  • University of York
    Department of Archaeology, present
  • Vriije Universiteit, Amsterdam
    Bijzonder Hoogleerar, 2015
  • University of Newcastle upon Tyne
    Biogeochemist, 1992 - 2003
  • Bristol University
    PDRA, 1990 - 1992
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University of York account
Introduction
Professor of Archaeology
Member of BioArCh
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Education
  • University of Wales, Bangor
    Zoology, 1979 - 1982
  • University of Glasgow
    Geology, 1983 - 1986
  • Leiden University
    Biochemistry, 1986 - 1990
Excellent Jamaican food, great fun
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