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Matt Uebel
Works at Reality Zealot Labs
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Every coding tutorial ever written. -@ossia 
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The "detail" is really something.
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Happy DNA Day! Did you know we can now edit the genome with a system called CRISPR-Cas9? Learn how it works with this video from the +McGovern Institute for Brain Research at MIT

#DNADay   #genetics   #DNA   #CRISPR   #MIT  
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Or a fake orca (if you try hard enough) heh
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Wait, who am I kidding? There was probably plenty of hookers and blow...Bloomberg just didn't want to tell us the whole story.
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This is why Google is awesome.
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Nice.
In this <em>World of Warcraft</em>-style game, hacking the game <em>is</em> the game.
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When Google Leaves Users Behind 

http://lauren.vortex.com/archive/001097.html 

I was just now reading over the publicity materials related to Google's newly announced (but long rumored) "Project Fi" wireless plan/experiment today, and found myself pondering a question. To wit: If I had the currently required Nexus 6 smartphone, would I be applying to be included in this new mobile offering?

And I realized the answer was no. Not so much because my current phone and plan are completely adequate to my needs, but rather for a couple of more depressing reasons.

One of these is the painful realization that I wouldn't necessarily have confidence that Google won't be abandoning this effort in relatively short order, triggering possible hassles at the egress end of the offer. Perhaps Project Fi signals the birth of a wonderful, consumer friendly, disruptive change to mobile that is long overdue. Or, Google might decide in a year or two just to pull the plug on it with short notice -- there are certainly well remembered precedents for the latter outcome from Google.

Another reason for my own current lack of enthusiasm for Project Pi is my personal embarrassment (I've consulted to Google) at the shabby way Google has treated -- and continues to treat -- many of their existing Android users.

I'm an enormous fan of Android, and totally committed to the Android ecosystem. But for the life of me I can't find valid justifications for Google's abandonment of literally vast numbers of Android users currently using older devices. Not everyone can afford to treat smartphones and tablets as easily disposable, especially when they seem to functioning perfectly well from the users' perspective.

Yet so many of these users are actually vulnerable to serious security flaws because Google refuses to patch the versions of Android still being run by large numbers of persons. 

Google has a range of explanations/excuses for this. Technical difficulty with backports. Uncooperative carriers. Concentrating efforts on the latest and greatest (more on that in a moment).

It's notable how quickly Google abandoned users even of their own flagship phones like the Galaxy Nexus when purchased directly from Google, where carrier cooperation wasn't even an issue (Google's excuse in this case was lack of driver support from a chip vendor, but somehow third-party hackers found a way around that problem.)

Given, no phone or other device lasts forever. Yet Google has (to my knowledge) not even directly, proactively informed users of these older devices about the security issues associated with these units, nor to inform them regarding the useful workarounds that actually do exist in many of these cases. Is it better for users to proceed using their devices in blitheful ignorance of these issues? I don't think so, anyway.

Again, I'm not suggesting that Google be required to update these older units forever. But why isn't there at least an official, well known Google page that directly and specifically explains the security status of these devices and the aforementioned workaround procedures? Why must users depend on (not alway trustworthy) outside articles (or blogs!) to learn about these matters? Google should take ownership of these important issues, rather than depending on others to dribble out such crucial information.

Google's seemingly endless juggernaut of great products belies problems that are not by any means unique to Google, but can ensnare large firms of any stripe, especially if they're engineering oriented. 

It's all too easy to focus on the latest and greatest, while too quickly deemphasizing serious consideration and maintenance of older products used by fewer users. Yet at the scale of many such firms, even relatively small percentages of users can represent very large numbers of actual human beings, many of whom are particularly in need of continuing attention, by virtue of their inability to buy into those wondrous new devices at the rate common for the early adopters.

And let's face it, engineering-oriented firms are often structured in a manner where career advancement is largely predicated on working in the bleeding edge of development -- there's little incentive for employees to seek roles maintaining older systems, backporting security patches, or refactoring code.

But these are all crucial roles, for the ways in which a firm supports all users, including those not in the new products adoption forefront, directly impacts public perception of how a firm's newer offerings will be perceived, and how that firm's treatment of users overall will be judged.

Something to think about perhaps, the next time you hear of a possibly great new product being announced. For one of the ways through which we can most clearly anticipate the future -- even our technological futures -- is to understand how we've been treated in the past.

Be seeing you -- in the future.

-- Lauren --
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Even if google drops the service in a few years one still gets a reasonable price and automatic free roaming between Sprint, T-Mobile and WIFI for that time.   Where is the bad?
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SciTech #ScienceSunday Digest - 17/2015.
Permalink here: http://www.scitechdigest.net/2015/04/human-embryo-crispr-more-accurate.html

Human embryo CRISPR, More accurate CRISPR, Programmable DNA photonics, DNA logic gates, Multifunctional neural probes, MRI Temporal boost, Protein structure algorithms, Emotionally aware machines, Invisible perceptual illusions, Single molecule switches. 

1. CRISPR to Modify Human Embryos
Biggest news of the week goes to the Chinese team who used CRISPR methods to produce genetically modified human embryos http://www.nature.com/news/chinese-scientists-genetically-modify-human-embryos-1.17378. The group used non-viable (extra chromosomes), pre-implantation embryos from local fertility clinics and used CRISPR-Cas9 to edit and replace a defective ß-thalassemia gene that typically causes a blood disorder. The group achieve low conversion rates and noted a large number of off-target mutations that resulted. However, several commentators noted that the group used an older version of CRISPR (newer versions are far more accurate) and these non-viable cells are probably not an optimal model. 

2. Engineering Even Greater Accuracy into CRISPR
In closely related news newer, accurate versions of CRISPR have been made 25-times even more accurate http://www.eurekalert.org/pub_releases/2015-04/hu-iai042315.php. The new CRISPR is depended on a specific molecule to be active, which is provided to the cells of interest for a relatively short period of time, and so ensures that the CRISPR system is only active for a short period of time. This severely limits the chances of off-target modifications. This work builds on prior studies to create CRISPR systems that require longer (and hence more specific) genetic sequences to recognise and seeks to more subtly alter the cellular equilibrium dynamics of CRISPR-Cas9 enzymes. The team predict that further improvements will lead to CRISPR systems that induce chance mutations at a rate below the level of natural chance mutations that the cell produces on a daily basis anyway. 

3. Programmable Matter with DNA Origami
A new modification to self-assembled DNA origami technology delivers the ability to create programmable, tunable fluorescent arrays http://phys.org/news/2015-04-cradle-silver-nanoclusters-synthetic-dna.html. This is achieved via two parts, (i) generating DNA nanotubes with defined positioning sites; in this case with spacings of 7nm, and (ii) generating silver nanoclusters bound to complementary DNA strands that bind the nanoclusters to the nanotube. The nanoclusters all have the same number of atoms and depending on the preparation and binding of DNA the number of atoms can be controlled to produce clusters tuned to fluoresce at different wavelengths of light, from green-blue to infrared.

4. Fuzzy & Boolean Logic Gates Made of DNA
In related news self-assembled DNA origami structures have been demonstrated that can sense two environmental signals (different oligonucleotides and miRNAs) and produce fluorescent outputs corresponding to Boolean logic gates AND, NAND, OR, NOR, XOR, NXOR http://www.nanowerk.com/spotlight/spotid=39795.php. There are a few different labs pursuing DNA computation in this way and good to see competition heating up. Possible applications for this particular embodiment include programmed biosensors that enter cells and only deliver a lethal drug payload if they successfully detect one or more cancer biomarkers for example. 

5. Multifunctional Neural Probes for Interfacing the Brain
Neural probes are becoming increasingly sophisticated as evidenced by these fibers and probes that are able to carry light, sense-collect-and-transmit electricity, and also deliver drugs http://www.technologyreview.com/photoessay/536806/a-swiss-army-knife-for-neuroscience/. Such fibers can both stimulate the brain in various ways and also record the resulting activity and allows researchers to controllably alter activity in different ways to see what the effect is. The fabrication process for the probes is quite innovative and involves forming different polymers in the desired pattern and then extruding and shrinking these into tiny fibers. 

6. Boosting Temporal Resolution for MRI
Recent advances in MRI technology provide a boost in temporal resolution that allows image capture at 100 frames per second - this can facilitate for example the detailed capture of the complex anatomical coordination that is necessary for a person to sing http://beckman.illinois.edu/news/2015/04/new-super-fast-mri-technique. Such dynamic real-time recordings offering both high spatial and temporal resolution hasn’t been possible until now, and in this application offers new insights into the complex dynamics of the neuromuscular system and larynx in order to better understand changes that occur due to various influences such as aging and disease. 

7. Improved Algorithms for Generating 3D Structures from 2D Images
A new image-processing algorithm results in a 100,000-fold speedup in determining 3D structures for proteins from sets of 2D images http://www.technologyreview.com/view/536976/an-algorithm-set-to-revolutionize-3-d-protein-structure-discovery/. The technique utilises (i) electron cryomicroscopy in which a purified protein solution is is frozen into a thin-film one molecule thick, and (ii) transmission electron microscopy in which the film is bombarded with electrons and those that pass through generate images or “shadowgrams” of the molecules in the film. The molecule structure is unknown and orientation is random. Generating the 3D structure from up to 200,000 images used to take two weeks on 300 cores, but now can be done in under 24 hours on a single workstation. 

8. Adapting to Machines that Know How You Feel
Wired had a good piece this week covering Affectiva and the coming ubiquity of computers that know and can respond to your emotional state http://www.wired.com/2015/04/computers-can-now-tell-feel-face/. Affectiva is offering its system to developers to help create a broad range of applications predominantly (for now) based on determining fine emotional nuances on faces. The promise here includes dynamic entertainment that responds to your emotions to give you a different experience to someone with different emotions, assisting those with emotion-identification handicaps to better understand people, automatically determine the emotional content of video, assist wearers of HUDs to determine a person’s emotion they may be trying to hide, targeting advertising to people based on their emotional state, and many many others.

9. The Perceptual Illusion of an Invisible Body
An interesting new psychological experiment explores the perceptual illusion on participants of having an invisible body http://ki.se/en/news/scientists-create-the-sensation-of-invisibility. Participants were instructed to look downwards as they wore a stereoscopic head mounted display, which received video input from a pair of binocular cameras that were pointed downwards towards the floor. A researcher then simultaneously touched the person’s body with a brush while touching the corresponding areas in empty space under the cameras with another brush. In less than a minute most people had altered body-maps and perceived the brush-touching-empty-air as actually touching themselves, and this was confirmed via measured stress response when a surprise knife was thrust into the same spot of empty space. I’m always fascinated by how easily malleable our sense of embodiment is. 

10. Towards Single Molecule Switches
A new candidate molecule approximately 3nm in size has been demonstrated to function as a single-molecule electronic switch http://www.hzdr.de/db/Cms?pOid=44032&pNid=0. The molecule possesses two stable states, one of which is an insulator and the other a conductor. The group was able to successfully switch the molecule into the “on” conductive state via light, which allowed current to flow between the two nanowire electrodes it was connected to. They can’t yet switch the molecule back to the “off” insulating state but are confident of achieving this in future.

Archive: http://www.scitechdigest.net/2015/04/human-embryo-crispr-more-accurate.html 
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I finished a Andy Dufresne charcoal pencil drawing this afternoon. My wife and I watched The Shawshank Redemption over our vacation and I got a few drawing ideas. 
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Perhaps, +Matt Uebel​! ;-)
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ICYMI: Puppet is available on Google Compute Engine as a Click to Deploy Solution. http://goo.gl/VPQEtg
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So cool
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Looked into that, since I need to change internet providers. While Fi doesn't seem to have a data cap, it is expensive - $20 base fee + $10 per gig of data, per month. So if you funnel lots of movies and shows, it adds up quickly.
https://fi.google.com/about/plan/

My current provider (Clearwire) has unlimited data for $40 per month. Which has been great for me or anyone on a tight budget. Sadly, Sprint bought them out and is closing the service later this year.
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Just as god intended.
 
Computers that know how you feel will soon be everywhere. "Personally, I'm not going to stop until this tech is embedded in all of our lives." 

"Starting today, Affectiva will invite developers to experiment with a 45-day free test and then license its tools. You remember Intel inside? El Kaliouby envisions 'Affectiva-embedded' technology, saying, 'It'll sit on your phone, in your car, in your fridge. It will sense your emotions and adapt seamlessly without being in your face.' It will just notice everything that's happening on your face."
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What is the Self? Watch Philosophy Animations Narrated by Stephen Fry on Sartre, Descartes & More http://www.openculture.com/2015/04/what-is-the-self-watch-philosophy-animations-narrated-by-stephen-fry.html 
Gillian Anderson (The X-Files) speak on what makes us human, the origins of the universe, and whether technology has changed us, and Harry Shearer speak on ethics — or rather, you've heard them narrate short educational animations from the BBC scripted by Philosophy Bites' Nigel Warburton.
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