Profile

Cover photo
Manish Chauhan
Works at Prabhu Dayal Builders (I) Pvt. Ltd.
Attends School of Planning and Architecture
Lived in New Delhi
131 followers|38,939 views
AboutPostsPhotosVideos

Stream

Manish Chauhan

Shared publicly  - 
 
 

Mapping a Living Brain, Neuron by Neuron

It looks like an oddly shaped campfire, but it is activity of individual neurons across a larval fish brain. It is the first time that researchers have been able to image an entire vertebrate brain at the level of single cells.

Brain function relies on communication between large populations of neurons across multiple brain areas, a full understanding of which would require knowledge of the time-varying activity of all neurons in the central nervous system. Here we use light-sheet microscopy to record activity, reported through the genetically encoded calcium indicator GCaMP5G, from the entire volume of the brain of the larval zebrafish in vivo at 0.8 Hz, capturing more than 80% of all neurons at single-cell resolution. Demonstrating how this technique can be used to reveal functionally defined circuits across the brain, we identify two populations of neurons with correlated activity patterns. One circuit consists of hindbrain neurons functionally coupled to spinal cord neuropil. The other consists of an anatomically symmetric population in the anterior hindbrain, with activity in the left and right halves oscillating in antiphase, on a timescale of 20 s, and coupled to equally slow oscillations in the inferior olive.

NATURE Methods | Article:
http://www.nature.com/nmeth/journal/vaop/ncurrent/full/nmeth.2434.html

Video Nature: nmeth.2434_video_s4

Brain Activity Map Project: http://en.wikipedia.org/wiki/Brain_Activity_Map_Project

.
1
Add a comment...
Have him in circles
131 people
vineet vasudev's profile photo
Soumyajit Chakraborty's profile photo
yasha sharan's profile photo
Gowthaman M's profile photo
ankit gupta's profile photo
Floyd Staten's profile photo
Lee Ryan Ebarle's profile photo
Len Han's profile photo
Lecram Nurg's profile photo
People
Have him in circles
131 people
vineet vasudev's profile photo
Soumyajit Chakraborty's profile photo
yasha sharan's profile photo
Gowthaman M's profile photo
ankit gupta's profile photo
Floyd Staten's profile photo
Lee Ryan Ebarle's profile photo
Len Han's profile photo
Lecram Nurg's profile photo
Work
Occupation
Architect
Employment
  • Prabhu Dayal Builders (I) Pvt. Ltd.
    Director, 2010 - present
  • EDMAC Consulting Pvt. Ltd.
    Architect, 2010 - 2011
  • Babbar and Babbar Architects
    Architect, 2009 - 2010
Places
Map of the places this user has livedMap of the places this user has livedMap of the places this user has lived
Previously
New Delhi
Links
Story
Tagline
Student at School of Planning and Architecture, pursuing PG in Building Engineering and Management
Bragging rights
Today, Tommorow's best labour saving device.
Education
  • School of Planning and Architecture
    Construction/Engineering, present
  • Sushant School Of Art and Architecture
    Architecture, 2009
  • APS
    High School
Basic Information
Gender
Male
Looking for
Friends, Networking
Relationship
Single
Apps with Google+ Sign-in
  • Zombie Highway 2
  • Real Steel World Robot Boxing