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Manfred Jung
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Manfred Jung

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Manfred Jung (ChemEpi):
ACS Medicinal Chemistry Letters - Inhibitors of the NAD+-Dependent Protein Desuccinylase and (cont) http://tl.gd/jmkouu

http://twitter.com/ChemEpi/status/259015944762953728

(gesendet mit Seesmic http://www.seesmic.com)
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Manfred Jung

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Our new review article on histone demethylases in Molecular Oncology is out.

The role of histone demethylases in cancer therapy

Hoffmann et al. http://dx.doi.org/10.1016/j.molonc.2012.07.004
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Manfred Jung (ChemEpi):
Our @ACSMedChemLett Viewpoint Article on bromodomain inhibitors is online here: http://pubs.acs.org/doi/abs/10.1021/ml300221t #epigenetics

http://twitter.com/ChemEpi/status/239626229144227840

Retweet von @conway_group tweet

(gesendet mit Seesmic http://www.seesmic.com)
Air Pollution and Industrial Hygiene · Apparatus and Plant Equipment · Cement, Concrete, and Related Building Materials · Ceramics · Electrochemical, Radiational, and Thermal Energy Technology · Essen...
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Video from the COST conference on Personalized Medicine #Epigenetics
1:28 151 likes, 11 dislikes. by DiscoveryNetworks. 26128 views. In Spotlight Videos. video · Billy Becks - Rocky Balboa (Clean Version). 3:45 227 likes, 1454 dislikes. by LibertyMusicGroup NEW. 105325...
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See our new paper in PLoS One on inhibition of histone phosphorlyation by Lestaurtinib.

PRK1 had been shown by R. Schüle to be a coactivator of the androgen receptor. We now show together with him and W. Sippl that the clinical candidate Lestaurtinib also inhibits #PRK1 potently and blocks histone phosphorylation and #androgen responsive gene transcription in cancer cells. Therefore, it should affect #epigenetic regulation.

#Epigenetics, #PLoS One
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Epigenetics and environment
Found on Twitter via #Epiexperts

http://www.plosone.org/article/info:doi%2F10.1371%2Fjournal.pone.0031901
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Acetyl cohesin identfied as a cellular HDAC8 substrate, linked to disease
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Nature Neuroscience paper links histone deacetylase HDAC2 to schizophrenia. New chances for antipsychotic drug discovery?

HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity

Kurita et al. Nature Neuroscience 15,1245–1254(2012)doi:10.1038/nn.3181
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Manfred Jung (ChemEpi):
Histone deacetylase gene variants predict brain vol changes in mult sclerosis, from Neurobio of Aging http://bit.ly/R0vBOh #epigenetics -CW

http://twitter.com/ChemEpi/status/239625328979496960

Retweet von @EpiExperts tweet

(gesendet mit Seesmic http://www.seesmic.com)
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See our News and Views article on histone methyltransferases and recent inhibitor development. #epigenetics #drugdiscovery  
Recent preclinical studies suggest that inhibitors of histone methyltransferases represent promising drug candidates for cancer therapy.
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Have him in circles
1,190 people
irollladen.de - Rollladen Rolltore Garagentor #Holzjalousie Funksteuerung r (nach Mass)'s profile photo
Tonny Johnson's profile photo
vicky alvarez's profile photo
Matthew Hall's profile photo
sofiya ambreen's profile photo
Ed Yong's profile photo
Jamie Lance's profile photo
Raoul Murfitt's profile photo
Aatish Bhatia's profile photo
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Uni Freiburg
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Working in Chemical Epigenetics, liking football, cooking, table tennis and biking
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