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Leo Saumure
Works at Interpreting New Zealand
Lives in Wellington, New Zealand
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So, I just checked out the Doodle 4 Google site where kids from Grades 1 - 12 submit their own Google Doodles. Although the voting button doesn't seem to be working for me, I am just gob-smacked by the talent of these young artists!
In some instances, because they are grouped by grade level, I can pick a personal favourite here and there, but some of them are just brimming with colour and depth and thoughtfulness, that I find it hard to pick just one!
 
Thousands of artists submitted "What Makes Me Me" artwork for Doodle 4 Google. Now it’s your turn to help pick the winner. Voting starts today! http://goo.gl/KKJVnQ
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Fabulous day in Wellington.
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I like bad science jokes!
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This was fantastic! I love the scientific method!
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Pretty great Inkscape project and a great reason to use it!
Say no to palm oil!
Title: The Orangutan Crysis: Info-graphic/Flat Design/Typography
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Help Beethoven arrange his masterpieces in today’s #GoogleDoodle
Moonlight Sonata wasn't as easy as you'd think it would be.
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A really good article. Saudi Arabia seems to be slow to change, but they are slowly changing. I hope Nassima Al Sadah gets the chance to run again.
Q: What did it feel like, signing your name in the year 2015 to that piece of government paper that says you’re now registered to vote? A: (Pause.) “It felt like … progress.”
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Have him in circles
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Leo Saumure

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A Google Collection from our walk in Makara.
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How does neuroblastoma evade immune cells?

✤ Neuroblastoma is a rare type of solid tumour that affects infants and very young children. It grows from nerve cells left over from development in the womb. Normally these cells vanish once they have done their job, and the reasons why they persist and carry on dividing in rare instances to become a cancer remain a mystery.

✤ One of the intriguing features of neuroblastoma is that the tumour creates an environment where the immune system is suppressed. Cancer cells often send out molecules to suppress the immune system, so that they can remain undetected within our bodies.

✤ Which is why immunotherapies, that can 'wake up the immune system', have so much promise. But first, we have to understand exactly how cancer cells suppress the immune system, so that we can develop those new immunotherapies.

✤ Our immune system is made up of many different types of cells. The most important is type of cell is known as a T-cell. T-cells can act as the soldiers of the immune system, actively engaged in ‘search and destroy’ missions looking for harmful disease-causing enemy cells. Unfortunately cancer cells can ‘hide’ from T-cells by sending out molecules that put these T-cells to sleep, through a process known as immunosuppression.

✤ But what are these molecules, and how do they cause immunosuppression? And most importantly, how can we exploit this knowledge to develop therapies that can re-activate these T cells?

✤ Researchers at the University of Birmingham have found that a molecule called arginine might be involved. Arginine is an amino acid normally found within our cells, and is broken down by an enzyme called arginase. The team discovered that neuroblastoma cells produce a lot of arginase enzyme. It means that in the environment surrounding neuroblastoma cells, known as the tumour microenvironment, arginine levels are very low. This reduced level of arginine is involved in the immunosuppression seen in neuroblastoma tumours. The team also showed that this same mechanism might be involved in immunosuppression in another childhood cancer, called acute myeloid leukaemia (AML).  

✤ So what is the impact of this research? We now know how important it is to regulate arginine levels in the tumour, so that T-cells can remain active. This immunosuppression also affects cell-based therapies, where engineered T cells are injected into patients. So it’s even more important that we make sure that the immunosuppressed tumour microenvironment is addressed before trying out new immunotherapies for treatment.

✤ It is tempting to think of giving arginine supplements to patients, to 'boost their immune system', but there is concern that it might feed tumour growth. A better approach would be to inhibit the activity of the enzyme, arginase. Excitingly, there are several compounds that act on arginase that are going through pre-clinical investigations. When given in combination with existing immunotherapies, these arginase inhibitors could greatly enhance treatment, and so improve patient outcome for the cancers where they work

Full paper: http://cancerres.aacrjournals.org/content/75/15/3043.long

Image credit: Neuroblastoma cell line, Wikipedia (https://en.wikipedia.org/wiki/Neuroblastoma#/media/File:BiggeggSH-SY5Y.jpg)
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Incredible research & hope that soon they may be able to find a solution. 
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Wow! The only thing missing from this group, is Montgomery Burns tenting his fingers exclaiming: "Excellent"!
 
This is truly sickening. 
* 6) We want to see an increasing use of fossil fuel, especially the least expensive, coal*
Climate deniers from across the world just met in Paris to agree the key messages they want to get across to the press. Here they are.
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Have him in circles
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Currently
Wellington, New Zealand
Previously
Kemptville, Ontario, Canada - Renfrew, Ontario, Canada - Long Beach, California, USA - Aylmer, Quebec, Canada - Nepean, Ontario, Canada - Edmonton, Alberta, Canada
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Gumbercules? I love that guy!
Introduction
I've got a few different blogs if you want to check them out: The Vespa Diaries(A personal blog),  Quest For Fiver (a blog about living a healthy lifestye) and now The Night Terrors (My webcomic).  I also contribute to Maple Glazed Kiwi (A Book/Movie Blog). You can learn a bit about me on Facebook...or by asking me. Look, just check out the blogs, and I'm sure you will be thoroughly confused.

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Database Administrator
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  • Interpreting New Zealand
    Database Administrator, 2007 - present
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Leo Saumure's +1's are the things they like, agree with, or want to recommend.
a review of The Power of Habit: Why We Do What We Do in Life and Business
www.goodreads.com

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The Day After New Year's is My Favorite Stat Holiday
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The Beekeeper's Apprentice - Laurie King
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This book was a real treat for me. I had just finished season 3 of Sherlock and this helped feed my cravings nicely. This book tells the sto

Michelle Papadopoulos Art
michellepapadopoulos.blogspot.com

These ink drawings for Inktober are so much fun to create! I really love working with ink. Ink and watercolor are something I really want to

Obesity research confirms long-term weight loss almost impossible
www.cbc.ca

There's a disturbing truth that is emerging from the science of obesity, Kelly Crowe reports. After years of study, it's becoming apparent t

Overkill - Vanda Symon
mapleglazedkiwi.blogspot.com

In a nutshell Set in the small town of Mataura on the South Island of New Zealand, this is in some ways a conventional murder mystery. It op

The Heart Broke In - James Meek
mapleglazedkiwi.blogspot.com

In a nutshell Told from the perspective of three main characters, whose lives are changed when one is asked to sacrifice another to save his

Do 'superfoods' really exist?
www.theguardian.com

From blueberries to nuts and whole grains, antioxidant-rich miracle foods were, we were told a decade ago, the key to combating stress, dise

Raising Hope
brinkofanultra.blogspot.com

Hello friends.....to my dismay it appears I have been rather behind on my post's on here. ahh where to begin? I have kept up with my running

Stupid Smart....and other nonsense.
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I love this phrase "that's stupid smart". Just last night I did something stupid in a smart way. I went out running on trails for about 7.5m

Someone Save Me!
brinkofanultra.blogspot.com

The stress has consumed me. The Step-back: Holiday weekend was great. I did a long run of 16 miles with a few friends and it felt great. I d

Average coffee consumption per day
unfilteredcafe.net

Poll I found this interesting statistic on statista.com showing the average daily consumption of coffee in the US, and it got me thinking...

Leafee Cafe
unfilteredcafe.wordpress.com

Podcast It is kind of fitting that this is the first cafe that we actually review as this was one of the first cafe's we had eaten at when w

Keep Calm
nightterriers.wordpress.com

Angus' joke falls flat, but he does find a nifty, new hat!

When You Swallow A Grenade
phenomena.nationalgeographic.com

In 1941, a rose killed a policeman. Albert Alexander, a 43-year-old policeman in Oxford, England, was pruning his …

Meet the camera that allows you to see around corners
io9.com

Researchers have already developed a device that allows you to see through eight-inch-thick concrete walls, but now, scientists have devised

New evidence suggests Archaeopteryx dressed in black
io9.com

Scientists have found a way to uncover feathered dinosaurs' true colors, and one of the first creatures to come under inspection is none oth

The Real Reason Why Your Kid Has ADHD?
io9.com

Attention deficit hyperactivity disorder (ADHD) is an incredibly complex disease — both in terms of treatment, and society's view of it. Whi

A Brilliant List of Science Books for People Who Want Their Minds Blown
io9.com

While everybody is getting stoned on turkey and starch this holiday season, you're hoping to join a secret collective of super-intelligent s

A 3D Printer That Works With Chocolate? Now You've Got My Attention
gizmodo.com

Instead of the toxic smell of melted plastics, while the Imagine 3D printer is doing its thing, your workspace will be filled with the aroma

We loved the amount of selection that this Roots store had available, and would have loved to have browsed the selection looking for some of the great Roots merchandise. But alas, we were virtually attacked by what I can only assume were commissioned sales people, because it was like they were buzzing flies, and we were the rotting carrion they were hoping to feast on. I couldn't touch an article of clothing without one of the staff member jumping in between me and the clothing shouting that they could find a size for me. My wife tried to look at a hoodie and a staff member jumped in between me and her offering to hold the hanger while she tried on the clothes. Added to this unpleasant situation was the fact that there was an irate and screaming customer trying to return an article of clothing that was no doubt force-fed to her in the past, and now she was suffering from buyers remorse. By-the-way...I am not being overly dramatic for effect. The staff at this store would follow you around virtually one step behind you, offering unwanted input and advice and would not leave you alone! Hey Roots: Want to sell some clothing? Let people browse your merchandise without being accosted. By comparison, the Roots store in Victoria was a dream. Staff greeted you warmly, and offered their services if needed. I only wish that store had the selection that the one on Robson had.
• • •
Public - a year ago
reviewed a year ago
We've been using Zaminka for the last four years, whenever we need to go back to Canada for a visit. The staff there are friendly, professional, and ALWAYS take excellent care of our two dogs. Whenever we go to pick up our dogs after the trip, they always look wonderful and healthy, as the staff will ask if we would like them bathed and groomed on pick-up. We're often told of some of our dog's various antics while at the Dog Motel which says to us that the staff take their jobs seriously, and they truly care about them. We will continue to use Zaminka for as long as they show such excellent care and concern for our pets.
• • •
Public - a year ago
reviewed a year ago
2 reviews
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