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John Foley
Works at AAAS
Attended University College Dublin - National University of Ireland, Dublin
Lived in Dublin, Ireland
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John Foley

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Just donated for the first time on One Today, a generosity app by Google. Give a little. Change a lot. https://onetoday.google.com/p/difw1hge
Did you know? There are only an estimated 80 jaguars remaining in Sonora, Mexico.
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John Foley

Basic Biology  - 
 
 
Inflammation is a classic example of a double-edged sword. Although the inflammatory response is necessary to get rid of an infection, for example, if inflammation goes on too long, it can do more harm than good.

For those interested in the mechanisms that promote and resolve inflammation, Science Signaling this week has put together a Focus Issue that highlights recent research in this area.
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John Foley

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Inflammation is a classic example of a double-edged sword. Although the inflammatory response is necessary to get rid of an infection, for example, if inflammation goes on too long, it can do more harm than good.

For those interested in the mechanisms that promote and resolve inflammation, Science Signaling this week has put together a Focus Issue that highlights recent research in this area.
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John Foley

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Sober words from Michael Eisen...
People who know me or read my blog will know that, in 1987, my father, a scientist at the NIH, killed himself after a member of his lab committed scientific fraud and he got caught up in the investigation. So I found the news this morning that Yoshiki Sasai, a Japanese stem cell scientist, ...
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Great advice on how to write your next manuscript...($)
 
Gould, Luna, and Vogel give some helpful advice on the art of crafting a scientific manuscript in Commentary in the latest issue of Nature Immunology. Great tips for anyone that wants to get better at communicating their scientific story. http://www.nature.com/ni/journal/v15/n8/full/ni.2923.html #sciencewriting  
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You're welcome. 
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John Foley

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Gould, Luna, and Vogel give some helpful advice on the art of crafting a scientific manuscript in Commentary in the latest issue of Nature Immunology. Great tips for anyone that wants to get better at communicating their scientific story. http://www.nature.com/ni/journal/v15/n8/full/ni.2923.html #sciencewriting  
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For those unable to get access to the original piece, here are some take-home messages:

1. Practice writing often - even if only with short pieces.
2. Keep the manuscript in mind throughout the whole project, not just at the end.
3. Communicate the findings in a story arc.
4. Revise, revise, revise.
5. Choose the appropriate journal and know your target audience.
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John Foley

Basic Biology  - 
 
A time-delayed method of drug delivery by nanoparticles leads to efficient killing of tumor cells.
 
The latest issue of Science Signaling is out now

Researchers engineer nanoparticles to deliver a one-two punch to tumor cells

In a Research Article this week, Michael Yaffe, Paula Hammond, and colleagues engineered nanoparticles that contained two drugs and were targeted to tumor cells. The first drug, which was in the membrane of the nanoparticles, rewired signaling pathways in the tumor cells and made the cells more sensitive to the effects of a second drug, which was contained within the core of the nanoparticles. This approach led to tumor shrinkage in mice. As Ronnie Fang and Liangfang Zhang discuss in an accompanying Perspective, this time-staggered release of drugs leads to very efficient killing of tumor cells.

In a second Research Article this week, Brian Schaefer and coworkers used imaging analysis to study the assembly of a cytosolic multiprotein complex that contains the adaptor protein p62 and promotes activation of the transcription factor NF-kB in T cells in response to T cell receptor stimulation.

In a Research Resource, Yosef Shiloh and colleagues used deep sequencing to identify the epigenetic and transcriptional dynamics of the response of human breast cancer cells to ionizing radiation.

Finally, read editors' summaries of exciting papers related to signaling research. This week, read about a group of studies that suggest that factors in the blood of young mice can rejuvenate muscle and cognitive function in older mice.
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John Foley

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Straight from the director's mouth...
Science chats with the movie’s director, novelist, and science adviser
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John Foley

Popular Science  - 
 
 
Inflammation is a classic example of a double-edged sword. Although the inflammatory response is necessary to get rid of an infection, for example, if inflammation goes on too long, it can do more harm than good.

For those interested in the mechanisms that promote and resolve inflammation, Science Signaling this week has put together a Focus Issue that highlights recent research in this area.
View original post
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John Foley

Popular Science  - 
 
 
Sober words from Michael Eisen...
People who know me or read my blog will know that, in 1987, my father, a scientist at the NIH, killed himself after a member of his lab committed scientific fraud and he got caught up in the investigation. So I found the news this morning that Yoshiki Sasai, a Japanese stem cell scientist, ...
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A very touching perspective. I was not aware of this story although I knew that the Eisens came from a family of scientists. 
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John Foley

Cool stuff  - 
 
Great advice on how to write your next manuscript...($)
 
Gould, Luna, and Vogel give some helpful advice on the art of crafting a scientific manuscript in Commentary in the latest issue of Nature Immunology. Great tips for anyone that wants to get better at communicating their scientific story. http://www.nature.com/ni/journal/v15/n8/full/ni.2923.html #sciencewriting  
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Great John, thanks!!!
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John Foley

Irish Community  - 
 
Well, as you can see from Claire Santry's blog post, the irishgenealogy.ie web site has been updated with civil records, but I have to say that it's been a frustrating evening trying to use the site. Perhaps it's due to first-day teething problems, but the searches are very hit and miss, the information that's provided is disappointing, and the Captcha system they use is very irritating. Here's hoping that things will improve in the next few days...
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Story
Introduction
A graduate of University College Dublin, Ireland, where I earned my B.Sc. and Ph.D. in biochemistry, and a former Research Fellow at the National Institutes of Health, Bethesda, MD, USA, I currently work as a Senior Editor for the journal Science Signaling, which is published by AAAS, the publisher of Science magazine and Science Translational Medicine. In my spare time, I dabble in black and white film photography and Irish family history. The views expressed here are solely my own and do not necessarily reflect those of AAAS.
Education
  • University College Dublin - National University of Ireland, Dublin
Basic Information
Gender
Male
Relationship
Married
Work
Occupation
Managing Editor, Science Signaling
Employment
  • AAAS
    Managing Editor, Science Signaling, 2016 - present
  • AAAS
    Senior Editor, Science Signaling, 2012 - 2016
  • AAAS
    Associate Editor, Science Signaling, 2007 - 2012
  • National Institutes of Health
    Research Fellow, 2000 - 2007
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Map of the places this user has livedMap of the places this user has livedMap of the places this user has lived
Previously
Dublin, Ireland - Washington, DC, USA.
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Back To Our Past 2015 – Review
www.irishgenealogynews.com

The three-day genealogy and dna extravaganza of Back To Our Past got underway at the RDS yesterday, on a beautiful sunny morning in Dublin.

Here’s what Ridley Scott has to say about the science in The Martian
news.sciencemag.org

Science chats with the movie’s director, novelist, and science adviser

Page 38, Microfilm 04250 / 01, Enniscorthy, Ferns - Catholic Parish Regi...
registers.nli.ie

This website contains images from the NLI’s collection of Catholic parish register microfilms. The registers contain records of baptisms and

A Variety of Unprocessed Foods Cut into Uncannily Precise 2.5cm Cubes by...
www.thisiscolossal.com

In 2014, Dutch newspaper De Volkskrant contacted conceptual design studio Lernert & Sander to create a piece for a special documentary photo

Free access to Irish Newspaper Archive: today only
www.irishgenealogynews.com

Irish Newspaper Archive is offering an impromptu day of free access to its entire database. It's on today and only today. To take advantage

Coming soon: Co Tipperary's mid-C19th Rate Books
www.irishgenealogynews.com

If you have Tipperary ancestors, you'll be pleased to learn that some terrific new records are going to become available in the not too dist

Chocolates That Represent Japanese Onomatopoeic Words To Describe Textur...
www.spoon-tamago.com

Chocolates That Represent Japanese Onomatopoeic Words To Describe Texture

IrishGenealogy to upload abridged version of indexes
www.irishgenealogynews.com

After the unceremonial and cruelly swift removal of the much-heralded 'enhanced' version of Ireland's civil registration indexes amid privac

Family Search launches Irish Genealogy webinar series
www.irishgenealogynews.com

The LDS Family History Library will be presenting a series of Irish Genealogy Research webinars from 15–19 September. These free classes are

Our Wicklow Heritage launches
www.irishgenealogynews.com

Our Wicklow Heritage is one of a growing network of community sites across Ireland but the first to showcase the heritage of an entire count

Yoshiki Sasai and the deadly consequences of science misconduct witchhunts
www.michaeleisen.org

People who know me or read my blog will know that, in 1987, my father, a scientist at the NIH, killed himself after a member of his lab comm

Broadchurch
market.android.com

Broadchurch is an 8-part drama series which looks at how the murder of a boy - Danny Latimer - affects a small, market town in Dorset. It wi

Latest on IrishGenealogy.ie bmd indexes fiasco
www.irishgenealogynews.com

It's a week now since the brand-new 'enhanced' civil registration indexes were unceremoniously pulled from IrishGenealogy.ie at the insisten

Tánaiste publishes Civil Registration (Amendment) Bill, 2014
www.irishgenealogynews.com

With the removal of the 'enhanced' version of the GRO civil registration indexes from IrishGenealogy.ie and the likelihood that these will n

Privacy issues close civil registration indexes site
www.irishgenealogynews.com

Just three weeks on from the launch of the General Register Office's civil registration indexes on IrishGenealogy.ie, the entire collection

More Dublin City Electoral Lists launched online
www.irishgenealogynews.com

Dublin City Libraries have digitised another tranche of Dublin City's early-20th-century electoral lists. This time, it's the turn of 1911,

Irish Roots
www.irishtimes.com

The General Register Office indexes online

'Enhanced' online bmd indexes searchable up to 2013
irish-genealogy-news.blogspot.com

The General Register Office's 'enhanced' indexes to Ireland's civil registration records are in the process of being uploaded to IrishGeneal