The top picture looks more natural. The depth of field isn't extremely shallow, so there might be "too little blur", but at least the blur looks relatively natural. The bottom picture, while superficially decent looking, doesn't have a consistent and natural-looking focus plane. Combine the difference of focus of the ears and the eyes, and there is no way the closest part of the pillow would be that sharp. Also, weird blur artifacts on the pillow to the left and right of the plushie. Finally, I think the background of the lower pic should be even more blurry with the dramatic difference between ears and eyes, which suggests a very narrow focus plane.
Whether the difference is big enough to matter, hmm. Not sure. It's kinda subtle, but I prefer the top one, and to me, that matters :-)