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Jeremy Byrne
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The first teaser trailer for Last Trump: The Beast Awakens has dropped, and it's fan service central from titles design to vocodered faux gravitas.

Who wouldn't thrill to the escalation of "temporary shutdown" of travel by Muslims "until we can figure out what's going on" from volksy stump rhetoric to policy statement, and the none-too-subtle juxtaposition of Hillarobama and the San Bernadino shooters? And while "quickly cut[ting] the head off ISIS, and tak[ing] their oil" is obviously boots-on-the-groundian (despite nukem-from-orbit accompanying imagery), it's the eschatologically immanent notion of somehow forcing Mexico to pay for a US infrastructure project so massive it might as well be terraforming that really pings the Vaydar.

But why stop at the Southern border? Find one suggestive NAFTA subclause and we'll annex Red Canadia too! No longer can we acquiesce to disorder. All remaining nations will bow to the First Nation of Greater America! (Sorry, spoilers.)

I'm the Military-Industrial Complex, and I approve this message.

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Best short story this year 

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At least in fibroblasts, ageing seems to be an epigenetic problem (ie. it's not an issue of DNA deterioration), and it may be amenable to something as simple as glycine supplementation.
Scientists were able to reverse the aging of cells ►

"Can the process of aging be delayed or even reversed? Research led by specially appointed Professor Jun-Ichi Hayashi from the University of Tsukuba in Japan has shown that, in human cell lines at least, it can. They also found that the regulation of two genes involved with the production of glycine, the smallest and simplest amino acid, is partly responsible for some of the characteristics of aging.

Professor Hayashi and his team made this exciting discovery while in the process of addressing some controversial issues surrounding a popular theory of aging.

This theory, the mitochondrial theory of aging, proposes that age-associated mitochondrial defects are controlled by the accumulation of mutations in the mitochondrial DNA. Abnormal mitochondrial function is one of the hallmarks of aging in many species, including humans. This is mostly due to the fact that the mitochondrion is the so-called powerhouse of the cell as it produces energy in a process called cellular respiration. Damage to the mitochondrial DNA results in changes or mutations in the DNA sequence. Accumulation of these changes is associated with a reduced lifespan and early onset of aging-related characteristics such as weight and hair loss, curvature of the spine and osteoporosis.

There is, however, a growing body of conflicting evidence that has raised doubts about the validity of this theory. The Tsukuba team in particular has performed some compelling research that has led them to propose that age-associated mitochondrial defects are not controlled by the accumulation of mutations in the mitochondrial DNA but by another form of genetic regulation. The research, published this month in the journal Nature's Scientific Reports, looked at the function of the mitochondria in human fibroblast cell lines derived from young people (ranging in age from a fetus to a 12 year old) and elderly people (ranging in age from 80-97 years old). The researchers compared the mitochondrial respiration and the amount of DNA damage in the mitochondria of the two groups, expecting respiration to be reduced and DNA damage to be increased in the cells from the elderly group. While the elderly group had reduced respiration, in accordance with the current theory, there was, however, no difference in the amount of DNA damage between the elderly and young groups of cells. This led the researchers to propose that another form of genetic regulation, epigenetic regulation, may be responsible for the age-associated effects seen in the mitochondria.

Epigenetic regulation refers to changes, such as the addition of chemical structures or proteins, which alter the physical structure of the DNA, resulting in genes turning on or off. Unlike mutations, these changes do not affect the DNA sequence itself. If this theory is correct, then genetically reprogramming the cells to an embryonic stem cell-like state would remove any epigenetic changes associated with the mitochondrial DNA. In order to test this theory, the researchers reprogrammed human fibroblast cell lines derived from young and elderly people to an embryonic stem cell-like state. These cells were then turned back into fibroblasts and their mitochondrial respiratory function examined. Incredibly, the age-associated defects had been reversed -- all of the fibroblasts had respiration rates comparable to those of the fetal fibroblast cell line, irrespective of whether they were derived from young or elderly people. This indicates that the aging process in the mitochondrion is controlled by epigenetic regulation, not by mutations.

The researchers then looked for genes that might be controlled epigenetically resulting in these age-associated mitochondrial defects. Two genes that regulate glycine production in mitochondria, CGAT and SHMT2, were found. The researchers showed that by changing the regulation of these genes, they could induce defects or restore mitochondrial function in the fibroblast cell lines. In a compelling finding, the addition of glycine for 10 days to the culture medium of the 97 year old fibroblast cell line restored its respiratory function. This suggests that glycine treatment can reverse the age-associated respiration defects in the elderly human fibroblasts.

These findings reveal that, contrary to the mitochondrial theory of aging, epigenetic regulation controls age-associated respiration defects in human fibroblast cell lines. Can epigenetic regulation also control aging in humans? That theory remains to be tested, and if proven, could result in glycine supplements giving our older population a new lease of life."

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Another promising candidate anti-ageing technology, this one working on the same pathway as fasting.

Multicellularity is essentially a cooperative arrangement between between simple organisms to adopt specialist roles in order to reduce risk and increase viability. When that arrangement breaks down, and cells become senescent or cancerous, the organism as a whole is threatened, which in turn dooms its constituents. There are obvious parallels with civilisation that we'd do well to learn from.

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Nuclear energy apologists: you just don't get it, do you? You're so much Boromir in Rivendell: true-hearted men will not be corrupted; how I would drive the hosts of Mordor; blah blah. Nuclear energy is tainted by hellfire and Cold War terror: a damn'd spot that's never ever gonna fade away. As far as the public's concerned, you might as well argue for the "science" from Mengele's experiments in the camps. Not a good look at all. Forget your Thorium pixie-dust; wishing things were different doesn't make it so. You really have to let this go.

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OMG awesome! I was reading the lede before clicking through, thinking "Please let it be Ken MacLeod, please let it be Ken MacLeod..." #cultureisthenewtrek #moviefranchiseplz
Understatement of the millenium: Iain Banks wrote both mainstream fiction and Sci-Fi fiction under the name Iain M Banks. His Culture series includes nine novels and described a civilisation that was capable of hollowing out asteroids and transforming them into spacecraft.

 [ "Don't let on.  They still think we live on planets." ]

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Thousand year old ruins emerge from the jungle. (Prasat Prom, Koh Ker temple complex, Northern Cambodia.)

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The Abbott Government has made the controversial decision to give profit-driven private insurers the right to tender to run its new 'Primary Health Networks' (PHNs), set to oversee GP care Australia-wide. 

This means insurance companies, and not your GP, could end up making critical decisions about who gets treatment and how we're treated, with health groups already raising the alarm. It's the very system that's crippled American healthcare, driving up costs and leading to less care for fewer people. 

Profit-driven healthcare threatens the very foundation of our universal Medicare system, restricting access and quality of care, especially in areas where insurers don't stand to make money. The Government is accepting expressions of interest right now to operate the PHNs, so we need to act quickly. 

Will you call on the Government to keep private insurance companies from taking over GP-care by adding your name to the petition?

Sign the petition here:

#australia   #auspol   #tonyabbott   #medicare  
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