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Jaxon Lee
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Jaxon Lee

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That clip from "In The Pale Moonlight" still gives me the chills.
From the unforgettable characters to the compelling plots, this series truly stands out from the rest.
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Another +1 because it's so true!
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Jaxon Lee

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Interesting stuff for curious minds

"The town of Liberal shall have neither God, Hell, Church nor Saloon"
Um, I can tell you RIGHT NOW why it failed
Liberal, Missouri, was founded to be an atheist oasis in Bible country. But today, you'd never know it.
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Well there's your problem... You can't have life without debauchery. You need at least one bar in any town.
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interesting stuff for curious minds
 
The Evolution of Antibiotic Resistance

One of my favourite things about my job at the MRC is writing about all types of biomedical research, and not just cancer. This week I’ve been digging into the threat of antibiotic resistance, and it is truly sobering to read how bad a problem it is. Coincidentally I stumbled across this fantastic experiment carried out by a team of researchers at Harvard University. It illustrates how antibiotic resistance happens, and more importantly (and scarily!) how fast it happens. I love this experiment for the simplicity behind it, and how illuminating the results are.

✤ To study the evolution of antibiotic resistance, the researchers set up a giant petri dish. This rectangular dish was filled with agar that was dyed black (so that the bacteria could be seen easily) and topped off with soft agar (so that the bacteria could move easily).

✤ The plate was divided up into nine sections for antibiotic concentration. The outmost edges of the plate had no antibiotic, and then the dose was gradually increased until the centre of the plate had 3000 units of antibiotic.

✤ The researchers then put E. coli bacteria on the edge of the plate. These bacteria are able to move, and therefore when they used up all the nutrients in a local area, they spread through a mechanism called ‘chemotaxis’ – the bacteria are drawn towards the chemicals released by the nutrients in the nearby regions on the agar plate. But these nearby regions have antibiotics in them, so only bacteria that have evolved resistance can spread to these regions.

✤ It’s worth noting that the antibiotic starts out at a non-lethal dose, which means that a certain proportion of the bacteria will be able to survive it. Then, as the antibiotic gradually increases, it selects the bacteria that have mutations in their genes that allow them to survive despite ever-increasing concentrations of antibiotic.

✤ The beauty of this experiment is that it is possible to see this happening in the relatively short space of 11 days. What’s more, the researchers were able to sample the resistant bacteria and then sequence the genes to find out exactly how antibiotic resistance evolves.

✤ One of the most common mutations was in a gene known as dnaQ which codes for a protein that helps copy DNA when the cells divide. This protein has proof-reading abilities, but when it is mutated, the proof-reading ‘relaxes’ - resulting in a typo-ridden genome that has immense potential for accumulating more and more mutations very rapidly. In addition to dnaQ mutations, the bacteria also had mutations in genes involved in the folate biosynthesis pathway, which is the main target of the antibiotic used in this experiment.

✤ It’s also worth noting that mutations that increased antibiotic resistance came at a cost – these mutant bacterial strains were smaller due to reduced growth. But as soon as the mutants established themselves in the antibiotic-filled region, compensatory mutations kicked in and they were able to reach normal size.

✤ In the end, the bacteria at the centre of the plate were able to tolerate a dose of antibiotics that was 1000 times higher than that tolerated by the starting bacteria. It’s terrifying to realise how under the right conditions, bacteria can evolve so quickly. It’s also sobering to realise that antibiotics, a discovery that transformed modern medicine, may soon be obsolete thanks to the wide-spread misuse of antibiotics in agriculture and medical settings.

Full text research paper: http://science.sciencemag.org/content/353/6304/1147.full

More writing on antibiotic resistance: https://www.statnews.com/2016/09/12/superbug-antibiotic-resistance-history/ and http://phenomena.nationalgeographic.com/2015/11/21/mcr-gene-colistin/
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Jamie Bamber. Apollo from BSG. But I respect what he's trying to do.
It usually happens at an airport gate. Les Snead will notice people whispering, and one will ask, “Are you Matthew McConaughey?”
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ha
 
"And when they send us mosquitoes, they're not sending their best."
Speaking to a capacity crowd of elderly racists in South Florida, Presidential hopeful Donald Trump announced that he has a plan to contain the Zik...
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In honor of #StarTrek50, revisit our #GoogleDoodle celebrating the anniversary of its first broadcast → https://goo.gl/w1WlVr
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interesting stuff for curious minds
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I'm going to hell for laughing at this one
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If you're an old series junkie, please check these out. You need to give it two episodes to shake off the jarring feeling of mimicry. But by the third, I grokked what they were doing and by the fourth, I was enjoying some amazing work by truly inspired and dedicated fans.
"Star Trek" and all related marks, logos and characters are solely owned by CBS Studios Inc. This fan production is not endorsed by, sponsored by, nor affili...
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political, but not partisan. interesting stuff for curious minds

"It is tempting to think that, when policies sold on dodgy prospectuses start to fail, lied-to supporters might see the error of their ways. The worst part of post-truth politics, though, is that this self-correction cannot be relied on. When lies make the political system dysfunctional, its poor results can feed the alienation and lack of trust in institutions that make the post-truth play possible in the first place."
 
Politicians have always lied. Does it matter if they leave the truth behind entirely?
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Is Taibbi going to lose his warrior credentials after writing this article:

http://www.rollingstone.com/politics/features/why-matt-yglesias-should-unwrite-his-latest-column-w438718
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"The things you own end up owning you."  --Tyler Durden
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Yes, I know it's a chain. But it's also a nice family dinner on the west side with a full bar and delightful service. Meatballs are amazing, and my picky 6yo daughter loves the four cheese pasta. And did I mention that it's cheap? The west side needs more Figos.
Public - in the last week
reviewed in the last week
Great service, cool outside/inside fusion seating. Don't let the pretty millennial hipsters fool you; this place is very kid friendly. Coloring book, crayons, drinks with bendy straws, the works. The tacos are excellent. The meats are seasoned and cooked to perfection. My only gripe? Store bought tortillas... These bland, uncooked corn tortillas are the definition of meh. I would have preferred some light grilling, or even better homemade like the ones you get OTP. But, for a little trendy spot on Howell Mill, I will cease my complaining. The meats and atmosphere more than make up for bland tortillas. Oh, and they have Sol beers. Makes me smile.
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Public - a week ago
reviewed a week ago
very busy, but unloved Starbucks. It frequently looks less than clean, and orders don't seem to come out in any particular order. The employees are nice enough but they seem to lack cooperative synergy.
Public - 2 weeks ago
reviewed 2 weeks ago
45 reviews
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Rapidly becoming the El Pollo Loco that I crave in my life. This restaurant has improved over the last year. I got greeted on my last visit, the person taking my order was pleasant, and the food came out quickly. I am witholding the 5th star to see if this trend lasts. A year ago, this place was like the 7th level of hell.
Public - 2 weeks ago
reviewed 2 weeks ago
super busy at lunch time, but the food is sublime. I had smoked wings and collard greens. The greens literally made my toes tap in a little dance. (notice my accurate use of the word literally, although you could only judge this if you were with me)
Public - 2 weeks ago
reviewed 2 weeks ago
Something important and spiritual and cosmically significant just happened to me, and I need to share the experience. I walked into a gas station BBQ spot and my life changed. When I talk about my life to friends from now on, there will only be two times: the time BEFORE TDT BBQ, and the time after. First, let me clear something up. This is not really a gas station BBQ spot. This is a BBQ spot that happens to be connected to a gas station. One conjures up images of lukewarm meat under heat lamps next to slushies and hot dogs, and the other is REAL AND AUTHENTIC SMOKED MEAT FRESH OFF THE COALS. Shombe greeted and WELCOMED me as I approached his counter. I ordered, we had a couple of laughs, and I collected my HEAPING PORTIONS of takeout and drove home. When I opened up the boxes at home, the smell.... it was like that cartoon where the aroma of something literally lifts the character off the ground and floats them to where the food is. This happened to my 6yo daughter when she caught a whiff. What happened next can only be described as a murder scene because of all the bones... My daughter and I DEMOLISHED wings, ribs, mac & cheese, and green beans! The dry rub was amazing but not over-powering, the pork ribs were melt-in-your-mouth tender. And Shombe cooks the wings WHOLE. Yes, WHOLE wings. I ordered 10, but ended up with what I would have previously described as 20. I do not say this lightly, so get ready (read my other reviews for reference)... This is easily the best BBQ I have ever had. Beats DBA, Williamson Bros, Fox Bros, Jim N Nicks... you name it. When I asked my daughter how she was enjoying it, she got a little emotional and said, "Daddy, I am a little sad because nothing else I eat will taste this good. Ever." Enough said.
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Public - a month ago
reviewed a month ago