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Jasmine Wolfe (Basement Kitty)
Lives in TX
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Ebola vaccine trial stopped after clear demonstration of efficacy 
The outbreak of Ebola had led to a race to get a vaccine and two candidate vaccines were under development. The Canadian vaccine (manufactured by Merk) has passed the test with flying colors and the results were so conclusive the trial has been stopped in its present form.
The vaccine trial used a cluster randomization strategy since cases were already dwindling when the vaccine was ready. Primary and secondary contacts were given vaccine either immediately or after three weeks (the time gap was randomized) and the goal was to reduce cases of Ebola occurring after ten days (assuming that vaccine takes that much time). All 13 cases of Ebola occurred in the delayed vaccine group while none of the immediately vaccinated cluster developed the disease after ten days.  Among those who got vaccine at some point, no cases occured after six days which suggests that the vaccine efficacy kicks in about six days and an overall efficacy of 75%. 
The recombinant vaccine is based on vesicular stomatitis virus. 
_Efficacy and effectiveness of an rVSV-vectored vaccine
expressing Ebola surface glycoprotein: interim results from
the Guinea ring vaccination cluster-randomised trial_
http://www.thelancet.com/pb/assets/raw/Lancet/pdfs/S0140673615611175.pdf
Unusual clinical trial in Guinea offers promise for stopping epidemic
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Oh great. H/T +Valkyrie
 
Houston Chronicle: 10 ways climate change will ravage Texas

1 -- During the past 30 years, the typical Texan has experienced an average of 43 days per year of temperatures above 95°F. But by mid-century, that number is likely to reach up to 80 such days, and to reach up to 106 days per year by 2040-2059.

2 -- By 2020-2039, extreme heat driven by climate change will likely claim more than 2,570 additional lives each year in Texas—the highest total number of heat-related deaths for any state. Annual additional heat-related deaths are likely to climb to more than 4,500 by 2040-2059.

3 -- By mid-century, heat-related labor productivity will decline across all sectors in Texas, and will likely cost the economy up to $12.5 billion statewide each year, with a 1-in-20 likelihood of costing more than $19.6 billion annually.

4 -- By 2020-2039, rising electricity demand related solely to climate change is likely to increase residential and commercial energy expenditures by up to 7%. Those increases will likely grow to up to 12% by 2040-2059.

5 -- By 2020-2039, rising electricity demand related solely to climate change is likely to increase residential and commercial energy expenditures by up to 7%. Those increases will likely grow to up to 12% by 2040-2059.

6 -- With an annual value of $1.2 billion, corn is ranked Texas’ second most valuable crop. Absent significant agricultural adaptation, corn yields will likely decrease by as much as 22% by 2020-2039 and by as much as 39% in the following 20 years.

7 -- Cotton output will likely drop by as much as 6% by 2020-2039 and as much as 14% by 2040-2059. The state’s soybean crop is likely to drop by as much as 17% by 2020-2039.

8 -- If we continue on our current emissions path, mean sea level at Galveston will likely rise 1.5 to 2.0 feet by 2050 and 3.2 to 4.9 feet by 2100.

9 -- The storm-related losses attributed to climate change along the Texas shoreline are likely to increase by up to $222 million per year on average by 2030, and up to nearly $650 million annually by 2050, bringing the state’s likely total annual storm damage to more than $3.9 billion per year by mid-century.

10 -- $20.9 billion in Texas coastal property is likely to be flooded at high tide by 2030.

http://www.chron.com/news/houston-texas/texas/article/Study-climate-change-could-ravage-Texas-6414822.php lone star state TX us america warming climate science
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Your grandfather sounds like a very wise man. 
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Another danger to america
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Connecting the dots of Systemic Lupus Erythematosus: study links the interferons to defective apoptosis clearance and autoimmunity 
Lupus is the classic systemic autoimmune disease where our body's immune system torments multiple organs of the body from skin to kidney and brain. The hallmark of lupus is the formation of antibodies to chromatin and DNA, specifically to products of apoptosis or programmed cell death, and these antibodies then form immune complexes with chromatin and DNA and get deposited in skin, kidneys and other organs. Under normal circumstances, the end products of apoptosis are immune privileged, they are so efficiently cleared by tissue macrophages (Marginal zone macrophages in lympho nodes for example), so that immune system does not even get a look in. The mechanism by which the bodies of patients with Lupus failed to clear these apoptotic cell material was not known. While single gene defects that interfere with this process can cause lupus, none were found in the majority of patients. In the meantime, gene expression studies pointed at another culprit, namely the expression of signature of type I Interferons (of the kind used to treat patients with Hepatitis C infection) and the DNA/RNA containing immune complexes can induce the production of type I interferons by activating specialized antigen presenting cells called plasmacytoid dendric cells (pDCs) through toll like receptors 7 and 9 (TLR7 and TLR9) and the drugs that block this the antimalarial drugs chloroquine and hydroxychloroquine are key drugs in lupus therapy. However, the mechanism by which these differing abnormalities worked together was unclear until now. 
In this paper publshed in the Journal of Clinical Investigations, Hao Li et al have connected the dots linking these different pathways. They have demonstrated how Type I interferons can themselves cause decreased clearance of apoptotic material and this defective clearance can cause breakage of tolerance and cause autoantibodies and lupus life disease. Type I interferons act on Marginal Zone Macrophages indirectly through Marginal zone B cells that express Lymphotoxin Beta. In the presence of Interferon, these cells migrate inside the follcles and in the absence of Lymphotoxin beta signaling the Marginal zone macrophages are depleted and are less functional. In their place there is accumulation of plasmacytoid dendritic cells (pDCs) in the marginal zone and increased formation of germinal centers inside the follicles. Lymphotoxin beta acts through MKL1 to induce expression of MARCO which along with SIGN-R1 are important for clearance of apoptotic cell material. Decreased MKL1 and MARCO expressing Marginal zone macrophages and increased pDCs were found not only multiple animal models of Lupus but also in Lupus patients spleens showing that this is a common pathway in both animal and human lupus. Blocking Interferon protected the animals showing that it is where it all begins. Once there is decreased apoptosis, and breakage of tolerance to chromatin, immune complexes can further stimulate type I interferon production and perpetuate the vicious cycle. Interestingly Lymphotoxin beta from B cells is important for the proper functioning of marginal zone macrophages. The study provides a unified picture of how Lupus can be initiated and perpetuated by type I interferon signaling in susceptible individuals in the absence of any major genetic defects in any of the systems. #lupus

Interferon-induced mechanosensing defects impede apoptotic cell clearance in lupus
http://www.jci.org/articles/view/81059
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Snerk. 
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chortle , .. snort
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Can't make this stuff up.
An East Texas man was hospitalized early Thursday morning after a bullet he fired at an armadillo ricocheted back at his head, KLTV reported.
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ahahahahahaha
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It was a rough afternoon for air travel at Dallas/Fort Worth Airport today. One plane was forced to evacuate and another experienced a landing gear tire fire in separate incidents, officials said. An American Airlines flight reported possible smoke in the cabin and a Spirit Airlines flight...
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And thats the laws the gop neocons and teabillys along with the militias and neonazis have given us. We need to ban assault weapons high capacity magazines amour piercing ammo. Along with stringent legal and psychological assessments. 
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Stewart's biographer has more new information about what led to his retirement, and how Trevor Noah landed the gig
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Oh yeah, regardless, they always get bothered by one of the above. Even so-called hardcore progressives sometimes act like aholes when they find out your an atheist.
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We are less than a mote of dust in the wind in the vast emptiness of the universe.
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Photographer, Atheist, Progressive
Introduction
I enjoy reading, dancing, baking, cooking, photography, playing Scrabble, and just hanging out outdoors. I make candy, cross stitch book marks, and candles. Current member of  Metroplex Atheists and Atheist Nexus I am at those sites occasionally. More often than not though, I am hanging here on Google+. I am also a member of +Colby Browns Behind the Lens - Photo Critique Circle at group.as. And please, do check out my Deviant Art page. https://basementkitty.deviantart.com and my RedBubble page http://www.redbubble.com/people/blacktopaz
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Have the world's coolest brother +Mike DeFranco and the world's awesomest daughter=)
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TX
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Sagamore Hills, Ohio - Indianapolis, Indiana - Sun Prairie and Waterloo, Wisconsin - Folsom, California - Parma, Ohio - Brookpark, Ohio