In the brain, p53 acts as a guardian protein, keeping the status quo in a cell and not allowing cells to change from one type to another. By lowering the expression of p53, researchers were able to reprogram fibroblasts (skin cells) into neurons more easily.
To control movement and balance, dopamine signals travel from the substantia nigra in the midbrain up to brain regions including the corpus striatum, the globus pallidus, and the thalamus. But in Parkinson’s disease, most of the dopamine signals from the substantia nigra are lost.
This discovery opens up other types of cell reprogramming, too.
More at: http://bit.ly/1SO2nQk
The revolutionary system, which works to diagnose cancer at a tenth of the cost of competing technologies, is now in clinical trials in the US, UK and Australia, and is in the process of being commercialised by Clearbridge BioMedics.
“It’s like a non-invasive ‘liquid biopsy’ that can flag the presence of any type of solid cancer – like lung, breast, bowel, and so on – without the need for surgery,” said Dr Warkiani.
Photo: dividing breast cancer cell.
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