How to reduce an univariate target assay cost? Use an multivariate phenomics readout and machine learning http://biorxiv.org/content/early/2017/03/29/108399 #preprint
Repurposed High-Throughput Images Enable Biological Activity Prediction For Drug Discovery
We repurpose a High-Throughput (cell) Imaging (HTI) screen of a glucocorticoid receptor assay to predict target protein activity in multiple other seemingly unrelated assays. In two ongoing drug discovery projects, our repurposing approach increased hit rates by 60- to 250-fold over that of the primary project assays while increasing the chemical structure diversity of the hits. Our results suggest that data from available HTI screens are a rich ...
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