Profile

Cover photo
Jörg Kurt Wegner
Works at Janssen
Attended University of Tübingen
Lives in Mechelen, Belgium
590 followers|198,533 views
AboutPostsPhotos

Stream

Jörg Kurt Wegner

Shared publicly  - 
 
No, 'drug space' scientists alone will not be able to handle exponential data growth
2
1
Frank Oellien's profile photo
Add a comment...

Jörg Kurt Wegner

Shared publicly  - 
 
Impressions of the celtic harp concert of students from Lakshmi Matthieu  - http://sharpsound.be/ and http://www.lakshmi.be/
1
Add a comment...

Jörg Kurt Wegner

Shared publicly  - 
 
job opening - cytometry, high-content imaging, single cell sequencing https://www.linkedin.com/jobs2/view/43064472
Janssen Discovery Sciences is supporting transformational research harnessing state-of-the-art multi-parametric platforms and systems analysis of the immune response in preclinical models and clinical studies to identify and evaluate innovative interventions in oncology, pathogenic infections and auto-immune diseases and guide prophylactic and therapeutic vaccine development. This commitment aims to bridge the gap between the single molecule/sin...
1
1
Wim Vanroose's profile photo
Add a comment...

Jörg Kurt Wegner

Shared publicly  - 
 
 
Second of three-part series: A review and analysis of recent trends in AI, ML, and DL algorithms at leading labs, with a briefing on current applications, achievements, and challenges.
View original post
1
Add a comment...

Jörg Kurt Wegner changed his profile photo.

Shared publicly  - 
4
1
Alain Poncelet's profile photo
Add a comment...

Jörg Kurt Wegner

Shared publicly  - 
 
Can only applaud to this effort!
 
Looks like an interesting meeting next month in Cambridge, MA. The speakers will be talking about the issue of it reproducibility in academic target validation studies.


"A Day of Irreproducibility In Cambridge" http://feedly.com/e/azXxVIw0


1
Add a comment...
Have him in circles
590 people
Faycal BENABDELJALIL's profile photo
Adam Kraut's profile photo
Dariusz Plewczynski's profile photo
Alexander Grossmann's profile photo
ThePeacefulAtheistt TPA's profile photo
GroeneBroers MM's profile photo
Annepaka Eliyaraju's profile photo
Moneka Mirza's profile photo
Abe Collins's profile photo

Jörg Kurt Wegner

Shared publicly  - 
 
Please spread! - 3year postdoc job opening within Janssen (Spain) https://goo.gl/xedm1x  #postdoc #job #janssen #data #science
Janssen-Cilag S.A. (a subsidiary of the Johnson & Johnson pharmaceutical company) is looking for a post-doctoral data scientist for a 3 year contract to support Horizon 2020 ExCAPE project that includes partners from pharmaceutical industry, hi-tech, biotech and academia. We aim to address, together with you, the computational challenges of mining the rich data generated for a millions of chemical compounds from chemical structure descriptors to ...
1
1
Egon Willighagen's profile photo
Add a comment...

Jörg Kurt Wegner

Shared publicly  - 
 
I am co-author in a new HIV1PI+XRay article with the University of Southampton (UK) and Lunds University (Sweden)  http://www.ncbi.nlm.nih.gov/pubmed/25897791 
1
Add a comment...

Jörg Kurt Wegner

Shared publicly  - 
 
Janssen job opportunity: Computational Biologist - Immune response http://goo.gl/KoBIH3 #immunology #biology #computational
Click the link provided to see the complete job description.
2
1
Alain Poncelet's profile photo
Add a comment...

Jörg Kurt Wegner

commented on a post on Blogger.
Shared publicly  - 
 
Hi all, a few comments.
First, could you please correct my name in the 1. reference, my name is not "Jörg Wenger", but it is actually "Jörg Kurt Wegner"

Second, I clearly applaud the multi-task setting utilizing all data, not just isolated assay/protein/gene outcomes. It is not fully correct stating that "this is the first time the effect of adding additional data has been quantified in this domain", since various publications under the keyword "proteochemometrics" have done this before, here one of ours [vwhw+13]. What we can state correctly, is that the multi-task setting is not depending on related protein classes, only, like proteochemometrics is, but it can be used over all protein classes, or could even mix different column types of information for small molecules.

+Rajarshi Guha   I think it's not overfitting, but true multi-class or multi-task learning in which related classes contribute, though "related" must have nothing to do with enzyme classification trees, but predictive power via some valid hypothesis testing, which looks ok here.

+Günter Klambauer I agree, it would have been nice to point to the Tox21 challenge, also for seeing a Pharma relevant application https://tripod.nih.gov/tox21/challenge/leaderboard.jsp (won by Bioinf@JKU http://www.bioinf.jku.at )
I also would encourage more applications from GoogleResearch on the matter for toxicity at least, or even disease mechanisms [htc+14, arr11], since we all know that single target NME's are not a good predictor for clinical outcome. Then again, a contribution of multi-task to such outcomes was strictly speaking not shown yet either (besides JKU's deep learning winning Tox21, and various earlier proteochemometrics publications, ideally the ones with some phenotypic/clinical outcome).  

Finally, quoting "we look forward to continued improvement in virtual drug screening and its increasing impact in the discovery process for future drugs." ... so do we, though with the emphasis on multi-task rather than virtual screening (using often actives only!)!

Article (vwhw+13) van Westen, G. J. P.; Hendriks, A.; Wegner, J. K.; IJzerman, A. P.; van Vlijmen, H. W. T. & Bender, A. Significantly Improved HIV Inhibitor Efficacy Prediction Employing Proteochemometric Models Generated From Antivirogram Data PLoS Comput Biol, 2013, 9, e1002899 . DOI: http://dx.doi.org/10.1371/journal.pcbi.1002899

Article (arr11) Arrowsmith, J. Trial watch: Phase II failures: 2008–2010 Nature Reviews Drug Discovery, 2011, 10, 328-329 . DOI: http://dx.doi.org/10.1038/nrd3439

Article (htc+14) Hay, M.; Thomas, D. W.; Craighead, J. L.; Economides, C. & Rosenthal, J. Clinical development success rates for investigational drugs. Nat Biotechnol, 2014, 32, 40-51 . DOI: http://dx.doi.org/10.1038/nbt.2786
8
Sepp Hochreiter's profile photoPatrick Riley's profile photoJörg Kurt Wegner's profile photo
4 comments
 
Nvidia’s CEO features deep learning winning the Tox21 challenge on GTC2015, see 1:25 in https://www.youtube.com/watch?v=8AnV7xAvpLQ 
Add a comment...

Jörg Kurt Wegner

Shared publicly  - 
 
 
Paper: PPDMs – A resource for mapping small molecule bioactivities from ChEMBL to Pfam-A protein domains
We've just published a Open Access paper in Bioinformatics on an approach to annotate the region of ligand binding within a target protein. This has a lot of applications in the use of ChEMBL , in particular providing greater accuracy in mapping functional ...
We've just published a Open Access paper in Bioinformatics on an approach to annotate the region of ligand binding within a target protein. This has a lot of applications in the use of ChEMBL, in particular providing greater accuracy in mapping functional effects, improving ligand-based target ...
3
1
Dames Gurganus's profile photo
Add a comment...

Jörg Kurt Wegner

Shared publicly  - 
 
+Tudor I. Oprea and +John Overington - Congrats boys, love the grant topic, of course!!! Hopefully 'signatures' are used as well ;)
1
1
Tudor I. Oprea's profile photoFrank Oellien's profile photo
 
The data from lincscloud.org is on our radar and we're trying to make sense of (some of) it as we speak...
Add a comment...
People
Have him in circles
590 people
Faycal BENABDELJALIL's profile photo
Adam Kraut's profile photo
Dariusz Plewczynski's profile photo
Alexander Grossmann's profile photo
ThePeacefulAtheistt TPA's profile photo
GroeneBroers MM's profile photo
Annepaka Eliyaraju's profile photo
Moneka Mirza's profile photo
Abe Collins's profile photo
Work
Occupation
Senior Scientist
Skills
pro-activity, diverse and trusted networks, state-of-the-art science, personal information management (e.g. literature and more), computer science expertise, high reading affinity, system biology, system chemistry, Chemogenomics, Pharmacogenomics, Chemoproteomics
Employment
  • Janssen
    Senior Scientist, 2007 - present
    My major work focus is now Chemogenomics and system chemistry/biology. Previously my focus was computer-aided drug design and supporting multiple levels of the R&D drug design process starting from target validation, high-throughput screening analysis, fragment-based screening, protein construct design, hit2lead, lead optimization, SAR analysis, and structure-based drug design. My closest collaborators are colleagues in the chemistry, biology, screening, analytics, technology, and informatics areas. Due to a computer science background I am also strategically interested in risk reduction, optimization, data mining, data integration, and large-scale challenges in the life science domain. Some might call it (open) innovation. I have a natural affinity to collaboration, communication, and knowledge management principles, especially in the context of making innovation and communities sustainable. Two particular concepts being of great use for making this efficient are social media (many-to-many communication) and change management, aka Knowledge=People+Information.
  • Tibotec
    PostDoc, 2005 - 2007
Places
Map of the places this user has livedMap of the places this user has livedMap of the places this user has lived
Currently
Mechelen, Belgium
Previously
Villingen-Schwenningen - Tübingen
Story
Tagline
I am a collaboration, innovation, chemistry, drug design, computer science, and structural biology geek.
Introduction
I am working for Janssen (Johnson & Johnson). Before I was working as scientist in industry, I founded several 'open ...' communities. I see the benefit of social trust in people, but are fully aware of the challenges for industrial partners. Besides, I am an identical twin, married, a geek, information junkie, bookworm, and always interested in meeting people for having a chat or meal together.
JKW@LinkedIn

P.S.: The opinions expressed are my own personal opinions and do not represent my employer's view in any way.
Education
  • University of Tübingen
  • University of Erlangen
Basic Information
Gender
Male
Looking for
Networking
Other names
Joerg Kurt Wegner, JKW, Jörg Kurt Wegner, Jörg Wegner, joergkurtwegner, Jorg Wegner